Autonomic Neuroscience, Год журнала: 2022, Номер 245, С. 103071 - 103071
Опубликована: Дек. 24, 2022
Язык: Английский
Scientific Reports, Год журнала: 2022, Номер 12(1)
Опубликована: Апрель 11, 2022
Abstract This cross-sectional study aimed to investigate the post-acute consequences of COVID-19. We conducted a self-administered questionnaire survey on sequelae, psychological distress (K6), impairments in work performance (WFun), and COVID-19–related experiences stigma discrimination two designated COVID-19 hospitals Hiroshima Prefecture, Japan, between August 2020 March 2021. The prevalence sequelae was calculated by age severity. Factors independently associated with or were identified using logistic regression analysis. Among 127 patients who had recovered from COVID-19, 52.0% persistent symptoms at median 29 days [IQR 23–128] after onset. mild 49.5% sequelae. most frequent olfactory disorders (15.0%), taste (14.2%), cough (14.2%). Multivariate analysis showed that an independent risk factor for (adjusted odds ratios [AOR] ≥ 60 years vs. < 40 3.63, p = 0.0165). Possible noted 30.7% (17.9% males 45.0% females). Female sex presence factors distress. Of all participants, 29.1% possible performance. Experiences reported 43.3% participants. revealed significant impacts Long COVID health local communities. A large-scale, long-term cohort is desired.
Язык: Английский
Процитировано
76
Molecules, Год журнала: 2022, Номер 27(7), С. 2048 - 2048
Опубликована: Март 22, 2022
The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, angiotensin-converting enzyme (ACE2), causes downregulation, which subsequently leads dysregulation renin–angiotensin system (RAS) in favor ACE–angiotensin II (Ang II)–angiotensin type I receptor (AT1R) axis. AT1R has a major role RAS by being involved several physiological events including blood pressure control and electrolyte balance. Following SARS-CoV-2 infection, pathogenic episodes generated vasoconstriction, proinflammatory, profibrotic, prooxidative consequences Ang II–AT1R axis activation are accompanied hyperinflammatory state (cytokine storm) an distress (ARDS). AT1R, member G protein-coupled (GPCR) family, modulates deleterious effects through multiple downstream signaling pathways, among MAP kinases (ERK 1/2, JNK, p38MAPK), tyrosine (PDGF, EGFR, insulin receptor), nonreceptor (Src, JAK/STAT, focal adhesion kinase (FAK)), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. COVID-19 is well known for generating symptoms, but because ACE2 expressed various body tissues, extrapulmonary pathologies also manifested, neurologic disorders, vasculature myocardial complications, kidney injury, gastrointestinal hepatic hyperglycemia, dermatologic complications. Therefore, development drugs based on blockers, such as angiotensin blockers (ARBs), that inhibit damaging cascade may become one most promising approaches treatment near future. We herein review general features with special focus receptor-mediated different pathways leading specific responses. In addition, we provide latest insights into roles outcomes systems human body, ARBs tentative pharmacological agents treat COVID-19.
Язык: Английский
Процитировано
75
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Апрель 20, 2023
Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus - 2 (SARS-CoV-2) infection, or Long COVID, is a prevailing second pandemic with nearly 100 million affected individuals globally and counting. We propose visual description the complexity COVID its pathogenesis that can be used by researchers, clinicians, public health officials to guide global effort toward an improved understanding eventual mechanism-based provision care afflicted patients. The proposed visualization framework for should evidence-based, dynamic, modular, systems-level approach condition. Furthermore, further research such could establish strength relationships between pre-existing conditions (or risk factors), biological mechanisms, resulting clinical phenotypes outcomes COVID. Notwithstanding significant contribution disparities in access social determinants have on disease course long our model focuses primarily mechanisms. Accordingly, sets out scientific, clinical, efforts better understand abrogate burden imposed
Язык: Английский
Процитировано
65
Nature Reviews Cardiology, Год журнала: 2024, Номер 21(6), С. 379 - 395
Опубликована: Янв. 2, 2024
Язык: Английский
Процитировано
59
Molecular Neurobiology, Год журнала: 2020, Номер 58(2), С. 564 - 575
Опубликована: Сен. 29, 2020
Язык: Английский
Процитировано
132
Journal of Hazardous Materials, Год журнала: 2021, Номер 422, С. 126848 - 126848
Опубликована: Авг. 6, 2021
Язык: Английский
Процитировано
85
Journal of Neurotrauma, Год журнала: 2020, Номер 38(1), С. 1 - 43
Опубликована: Окт. 29, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple organs of disease 2019 (COVID-19) patients, including the brain. There are worldwide descriptions neurological deficits in COVID-19 patients. Central nervous system (CNS) symptoms can be present early course disease. As many as 55% hospitalized patients have been reported to disturbances three months after infection by SARS-CoV-2. mutability SARS-COV-2 and its potential directly affect CNS highlight urgency developing technology diagnose, manage, treat brain injury pathobiology SARS-CoV-2 associated sequelae this remain poorly understood. In review, we outline rationale for use blood biomarkers (BBs) diagnosis research needed incorporate their into clinical practice, improvements patient management outcomes that result. BBs could potentially provide tools detection Elevations cerebrospinal fluid (CSF) BB proteins analyzed CSF detect involvement with infectious diseases, human immunodeficiency tuberculous meningitis. approved U.S. Food Drug Administration mild versus moderate traumatic identified stroke, cardiac arrest, hypoxia, epilepsy. BBs, integrated other diagnostic tools, enhance understanding viral mechanisms injury, predict severity deficits, guide triage assignment appropriate medical pathways, assess efficacy therapeutic interventions
Язык: Английский
Процитировано
78
Frontiers in Immunology, Год журнала: 2021, Номер 11
Опубликована: Янв. 29, 2021
In late December 2019, multiple atypical pneumonia cases resulted in severe acute respiratory syndrome caused by a pathogen identified as novel coronavirus SARS-CoV-2. The most common disease 2019 (COVID-19) symptoms are pneumonia, fever, dry cough, and fatigue. However, some neurological complications following SARS-CoV-2 infection include confusion, cerebrovascular diseases, ataxia, hypogeusia, hyposmia, neuralgia, seizures. Indeed, growing literature demonstrates that neurotropism is feature of coronaviruses; therefore, the mechanisms already described other coronaviruses may also be applicable for Understanding underlying pathogenetic nervous system involvement essential to assess possible long-term alteration COVID-19. Here, we provide an overview associated regarding routes COVID-19 neuroinvasion, such trans-synapse-connected route olfactory pathway peripheral nerve terminals its implications central system.
Язык: Английский
Процитировано
78
Journal of Alzheimer s Disease, Год журнала: 2021, Номер 82(3), С. 883 - 898
Опубликована: Июнь 1, 2021
Cognitive impairment following SARS-CoV-2 infection is being increasingly recognized as an acute and possibly also long-term sequela of the disease. Direct viral entry well systemic mechanisms such cytokine storm are thought to contribute neuroinflammation in these patients. Biomarkers COVID-19-induced cognitive currently lacking, but there some limited evidence that could preferentially target frontal lobes, suggested by behavioral dysexecutive symptoms, fronto-temporal hypoperfusion on MRI, EEG slowing regions, hypometabolism 18F-FDG-PET. Possible confounders include due hypoxia mechanical ventilation post-traumatic stress disorder. Conversely, patients already suffering from dementia, their caregivers, have been greatly impacted disruption care caused COVID-19. Patients with dementia experienced worsening cognitive, behavioral, psychological rate COVID-19-related deaths disproportionately high among cognitively impaired people. Multiple factors, difficulties remembering executing safeguarding procedures, age, comorbidities, residing homes, poorer access hospital standard play a role increased morbidity mortality. Non-pharmacological interventions new technologies shown potential for management support caregivers.
Язык: Английский
Процитировано
76
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(8), С. 4081 - 4081
Опубликована: Апрель 15, 2021
COVID-19 is a severe respiratory disease caused by the newly identified human coronavirus (HCoV) Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The virus was discovered in December 2019, and March 2020, declared global pandemic World Health Organization (WHO) due to high number of cases. Although SARS-CoV-2 primarily affects system, several studies have reported neurological complications patients. Headache, dizziness, loss taste smell, encephalitis, encephalopathy, cerebrovascular diseases are most common that associated with COVID-19. In addition, seizures, neuromuscular junctions’ disorders, Guillain–Barré syndrome were as COVID-19, well neurodegenerative demyelinating disorders. However, management these conditions remains challenge. this review, we discuss prevalence, pathogenesis, mechanisms sequelae secondary infection. We aim update neurologists healthcare workers on possible conditions.
Язык: Английский
Процитировано
73