Microglia in epilepsy

Neurobiology of Disease, Год журнала: 2023, Номер 185, С. 106249 - 106249

Опубликована: Авг. 1, 2023

Epilepsy is one of most common chronic neurological disorders, and the antiseizure medications developed by targeting neurocentric mechanisms have not effectively reduced proportion patients with drug-resistant epilepsy. Further exploration cellular or molecular mechanism epilepsy expected to provide new options for treatment. Recently, more researches focus on brain network components other than neurons, among which microglia attracted much attention their diverse biological functions. As resident immune cells central nervous system, highly plastic transcription, morphology functional characteristics, can change dynamically in a context-dependent manner during progression In pathogenesis epilepsy, reactive interact epileptogenic performing crucial functions such as secretion soluble factors phagocytosis, thus continuously reshaping landscape epileptic microenvironment. Indeed, appear be both pro-epileptic anti-epileptic under different spatiotemporal contexts disease, rendering interventions biologically complex challenging. This comprehensive review critically summarizes pathophysiological role homeostasis alterations explores potential therapeutic modulatory targets microglia.

Язык: Английский

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miRNA-Based Technologies in Cancer Therapy

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(11), С. 1586 - 1586

Опубликована: Ноя. 9, 2023

The discovery of therapeutic miRNAs is one the most exciting challenges for pharmaceutical companies. Since first miRNA was discovered in 1993, our knowledge biology has grown considerably. Many studies have demonstrated that expression dysregulated many diseases, making them appealing tools novel approaches. This review aims to discuss biogenesis and function, as well highlight strategies delivering agents, presenting viral, non-viral, exosomic delivery approaches different cancer types. We also consider role microRNA-mediated drug repurposing therapy.

Язык: Английский

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Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels

Journal of Neuroinflammation, Год журнала: 2023, Номер 20(1)

Опубликована: Март 8, 2023

Although the advent of combination anti-retroviral therapy (cART) has transformed HIV into a manageable chronic disease, an estimated 30-50% people living with (PLWH) exhibit cognitive and motor deficits collectively known as HIV-associated neurocognitive disorders (HAND). A key driver HAND neuropathology is neuroinflammation, where proinflammatory mediators produced by activated microglia macrophages are thought to inflict neuronal injury loss. Moreover, dysregulation microbiota-gut-brain axis (MGBA) in PLWH, consequent gastrointestinal dysfunction dysbiosis, can lead neuroinflammation persistent impairment, which underscores need for new interventions.

Язык: Английский

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MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 10, 2024

Язык: Английский

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Total paeony glycoside relieves neuroinflammation to exert antidepressant effect via the interplay between NLRP3 inflammasome, pyroptosis and autophagy

Phytomedicine, Год журнала: 2024, Номер 128, С. 155519 - 155519

Опубликована: Март 8, 2024

Язык: Английский

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Potential Implications of miRNAs in the Pathogenesis, Diagnosis, and Therapeutics of Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16259 - 16259

Опубликована: Ноя. 13, 2023

Alzheimer’s disease (AD) is a complex multifactorial disorder that poses substantial burden on patients, caregivers, and society. Considering the increased aging population life expectancy, incidence of AD will continue to rise in following decades. However, molecular pathogenesis remains controversial, superior blood-based biomarker candidates for early diagnosis are still lacking, effective therapeutics halt or slow progression urgently needed. As powerful genetic regulators, microRNAs (miRNAs) receiving increasing attention due their implications initiation, development, theranostics various diseases, including AD. In this review, we summarize miRNAs directly target microtubule-associated protein tau (MAPT), amyloid precursor (APP), β-site APP-cleaving enzyme 1 (BACE1) transcripts regulate alternative splicing APP. We also discuss related kinases, such as glycogen synthase kinase (GSK)-3β, cyclin-dependent 5 (CDK5), death-associated (DAPK1), well apolipoprotein E, targeted by control phosphorylation amyloidogenic APP processing leading Aβ pathologies. Moreover, there evidence miRNA-mediated modulation inflammation. Furthermore, circulating serum plasma patients noninvasive biomarkers with diagnostic potential reviewed. addition, miRNA-based optimized nanocarriers exosomes options treatment discussed.

Язык: Английский

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Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

Brain Sciences, Год журнала: 2023, Номер 14(1), С. 19 - 19

Опубликована: Дек. 23, 2023

The term “neuroinflammation” defines the typical inflammatory response of brain closely related to onset many neurodegenerative diseases (NDs). Neuroinflammation is well known, but its mechanisms and pathways are not entirely comprehended. Some progresses have been achieved through efforts research. Consequently, new cellular molecular mechanisms, diverse conventional, emerging. In listing some those that will be subject our description discussion, essential important roles peripheral infiltrated monocytes clonotypic cells, alterations in gut–brain axis, dysregulation apelinergic system, endothelial glycocalyx component neuronal vascular units, variations expression genes levels encoding molecules by action microRNAs (miRNAs), or other epigenetic factors distinctive transcriptional factors, as role autophagy, ferroptosis, sex differences, modifications circadian cycle. Such can add significantly understanding complex etiological puzzle neuroinflammation ND. addition, they could represent biomarkers targets ND, which increasing elderly.

Язык: Английский

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Therapeutic Potentials of MicroRNA-126 in Cerebral Ischemia

Molecular Neurobiology, Год журнала: 2023, Номер 60(4), С. 2062 - 2069

Опубликована: Янв. 4, 2023

Язык: Английский

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Targeting Microglia in Alzheimer’s Disease: Pathogenesis and Potential Therapeutic Strategies

Biomolecules, Год журнала: 2024, Номер 14(7), С. 833 - 833

Опубликована: Июль 11, 2024

Microglia, as resident macrophages in the central nervous system, play a multifunctional role pathogenesis of Alzheimer’s disease (AD). Their clustering around amyloid-β (Aβ) deposits is core pathological feature AD. Recent advances single-cell RNA sequencing (scRNA-seq) and single-nucleus (snRNA-seq) have revealed dynamic changes microglial phenotypes over time across different brain regions during aging AD progression. As advances, microglia primarily exhibit impaired phagocytosis Aβ tau, along with release pro-inflammatory cytokines that damage synapses neurons. Targeting has emerged potential therapeutic approach for Treatment strategies involving can be broadly categorized into two aspects: (1) enhancing function: This involves augmenting their phagocytic ability against cellular debris (2) mitigating neuroinflammation: Strategies include inhibiting TNF-α signaling to reduce neuroinflammatory response triggered by microglia. Clinical trials exploring microglia-related approaches treatment garnered attention. Additionally, natural products show promise beneficial effects suppressing inflammatory responses. Clarifying dynamics, understanding roles, novel will advance our fight

Язык: Английский

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Parkinson’s Disease and MicroRNAs: A Duel Between Inhibition and Stimulation of Apoptosis in Neuronal Cells

Molecular Neurobiology, Год журнала: 2024, Номер 61(11), С. 8552 - 8574

Опубликована: Март 23, 2024

Язык: Английский

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