Nutritional Neuroscience,
Год журнала:
2023,
Номер
27(8), С. 870 - 886
Опубликована: Сен. 20, 2023
ABSTRACTParkinson's
disease
(PD)
is
a
chronic
neurodegenerative
(NDD)
due
to
the
degeneration
of
dopaminergic
neurons
(DNs)
in
substantia
nigra
(SN).
PD
characterized
by
diverse
motor
symptoms
such
as
rigidity,
resting
tremors,
and
bradykinesia,
non-motor
cognitive
dysfunction
sleep
disturbances.
Vitamin
D
(VD),
VD
receptor
(VDR),
metabolites
are
present
brain
play
role
maintaining
development,
differentiation,
functions
DNs.
VDRs
exert
protective
effects
against
neuropathology
modulating
functional
capacity
DNs
neurotransmission
SN.
In
virtue
its
anti-inflammatory
antioxidant
activities,
could
be
effective
prevention
treatment
PD.
exerts
neuroprotective
effect
reducing
oxidative
stress
mitochondrial
dysfunction,
increasing
autophagy
brain-derived
neurotrophic
factor
(BDNF).
Low
serum
level
connected
with
development
dementia
The
VD-mediated
augmenting
interrelated
safeguarding
synaptic
plasticity
modulation
neurotransmitter
release.
deficiency
linked
severity
olfactory
which
precedes
progression
symptomatic
However,
precise
remains
unidentified,
there
conflict
about
whether
can
ameliorate
or
not.KEYWORDS:
Parkinson's
diseaseVitamin
DVD
receptorBDNFsubstantia
nigraAutophagyOxidative
stressdopaminergic
AcknowledgementsNot
applicable.Authors'
contributionsAAH
conceptualized
manuscript,
wrote,
edited,
reviewed
main
text
approved
final
edition
manuscript.Disclosure
statementNo
potential
interest
was
reported
author(s).Additional
informationFundingThe
author(s)
no
funding
associated
work
featured
this
article.
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(11)
Опубликована: Июнь 1, 2024
Abstract
Cyclin‐dependent
kinase
5
(Cdk5)
is
a
protein
expressed
in
postmitotic
neurons
the
central
nervous
system
(CNS).
Cdk5
activated
by
p35
and
p39
which
are
neuron
regulatory
subunits.
Cdk5/p35
complex
calpain
protease
to
form
has
neuroprotective
effect
regulating
synaptic
plasticity
memory
functions.
However,
exaggerated
implicated
different
types
of
neurodegenerative
diseases
including
Parkinson
disease
(PD).
Therefore,
modulation
signalling
may
mitigate
PD
neuropathology.
aim
present
review
was
discuss
critical
role
pathogenesis
PD,
how
inhibitors
effectual
management
PD.
In
conclusion,
overactivated
involved
development
neurodegeneration,
Cdk5/calpain
such
as
statins,
metformin,
fenofibrates
rosiglitazone
can
attenuate
progression
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2023,
Номер
38(1)
Опубликована: Дек. 9, 2023
COVID-19
is
caused
by
a
novel
SARS-CoV-2
leading
to
pulmonary
and
extra-pulmonary
manifestations
due
oxidative
stress
(OS)
development
hyperinflammation.
primarily
asymptomatic
though
it
may
cause
acute
lung
injury
(ALI),
respiratory
distress
syndrome
(ARDS),
systemic
inflammation,
thrombotic
events
in
severe
cases.
SARS-CoV-2-induced
OS
triggers
the
activation
of
different
signaling
pathways,
which
counterbalances
this
complication.
One
these
pathways
nuclear
factor
erythroid
2-related
2
(Nrf2),
induces
series
cellular
interactions
mitigate
SARS-CoV-2-mediated
viral
toxicity
OS-induced
injury.
Nrf2
pathway
inhibits
expression
pro-inflammatory
cytokines
cytokine
storm
COVID-19.
Therefore,
activators
play
an
essential
role
reducing
infection-induced
inflammation
suppressing
NLRP3
inflammasome
Furthermore,
can
attenuate
endothelial
dysfunction
(ED),
renin-angiotensin
system
(RAS)
dysregulation,
immune
thrombosis,
coagulopathy.
Thus
mini-review
tries
clarify
possible
management
could
be
effective
therapeutic
strategy
Covid-19.
Preclinical
clinical
studies
are
recommended
regard.
Nutritional Neuroscience,
Год журнала:
2023,
Номер
27(8), С. 870 - 886
Опубликована: Сен. 20, 2023
ABSTRACTParkinson's
disease
(PD)
is
a
chronic
neurodegenerative
(NDD)
due
to
the
degeneration
of
dopaminergic
neurons
(DNs)
in
substantia
nigra
(SN).
PD
characterized
by
diverse
motor
symptoms
such
as
rigidity,
resting
tremors,
and
bradykinesia,
non-motor
cognitive
dysfunction
sleep
disturbances.
Vitamin
D
(VD),
VD
receptor
(VDR),
metabolites
are
present
brain
play
role
maintaining
development,
differentiation,
functions
DNs.
VDRs
exert
protective
effects
against
neuropathology
modulating
functional
capacity
DNs
neurotransmission
SN.
In
virtue
its
anti-inflammatory
antioxidant
activities,
could
be
effective
prevention
treatment
PD.
exerts
neuroprotective
effect
reducing
oxidative
stress
mitochondrial
dysfunction,
increasing
autophagy
brain-derived
neurotrophic
factor
(BDNF).
Low
serum
level
connected
with
development
dementia
The
VD-mediated
augmenting
interrelated
safeguarding
synaptic
plasticity
modulation
neurotransmitter
release.
deficiency
linked
severity
olfactory
which
precedes
progression
symptomatic
However,
precise
remains
unidentified,
there
conflict
about
whether
can
ameliorate
or
not.KEYWORDS:
Parkinson's
diseaseVitamin
DVD
receptorBDNFsubstantia
nigraAutophagyOxidative
stressdopaminergic
AcknowledgementsNot
applicable.Authors'
contributionsAAH
conceptualized
manuscript,
wrote,
edited,
reviewed
main
text
approved
final
edition
manuscript.Disclosure
statementNo
potential
interest
was
reported
author(s).Additional
informationFundingThe
author(s)
no
funding
associated
work
featured
this
article.
