Expert Opinion on Therapeutic Targets,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Дек. 23, 2024
Introduction
Ischemic
stroke
(IS),
a
major
cause
of
mortality
and
disability
worldwide,
remains
significant
healthcare
challenge
due
to
limited
therapeutic
options.
Ferroptosis,
distinct
iron-dependent
form
regulated
cell
death
characterized
by
lipid
peroxidation
oxidative
stress,
has
emerged
as
crucial
mechanism
in
IS
pathophysiology.
This
review
explores
the
role
ferroptosis
its
potential
for
driving
innovative
strategies.
Cell
death
is
one
of
the
most
important
mechanisms
maintaining
homeostasis
in
our
body.
Ferroptosis
and
pyroptosis
are
forms
necrosis-like
cell
death.
These
modalities
play
key
roles
pathophysiology
cancer,
cardiovascular,
neurological
diseases,
other
pathologies.
Transition
metals
abundant
group
elements
all
living
organisms.
This
paper
presents
a
summary
ferroptosis
pathways
their
connection
to
significant
transition
metals,
namely
zinc
(Zn),
copper
(Cu),
molybdenum
(Mo),
lead
(Pb),
cobalt
(Co),
iron
(Fe),
cadmium
(Cd),
nickel
(Ni),
mercury
(Hg),
uranium
(U),
platinum
(Pt),
crucial
element,
selenium
(Se).
Authors
aim
summarize
up-to-date
knowledge
this
topic.In
review,
there
categorized
highlighted
common
patterns
alterations
by
metals.
Special
attention
given
since
collected
data
support
its
dual
nature
action
both
pyroptosis.
All
findings
presented
together
with
brief
description
major
biochemical
involving
mentioned
visualized
attached
comprehensive
figures.This
work
concludes
that
majority
disruptions
studied
metals'
impacts
fate,
influencing
survival
cells
complex
system
altered
pathways.
Therefore,
opens
up
space
for
further
research.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 24, 2025
Flavonoids
are
a
class
of
important
polyphenolic
compounds,
renowned
for
their
antioxidant
properties.
However,
recent
studies
have
uncovered
an
additional
function
these
natural
flavonoids:
ability
to
inhibit
ferroptosis.
Ferroptosis
is
key
mechanism
driving
cell
death
in
central
nervous
system
(CNS)
diseases,
including
both
acute
injuries
and
chronic
neurodegenerative
disorders,
characterized
by
iron
overload-induced
lipid
peroxidation
dysfunction
the
defense
system.
This
review
discusses
therapeutic
potential
flavonoids
from
herbs
nutraceuticals
as
ferroptosis
inhibitors
CNS
focusing
on
molecular
mechanisms,
summarizing
findings
preclinical
animal
models,
providing
insights
clinical
translation.
We
specifically
highlight
such
Baicalin,
Baicalein,
Chrysin,
Vitexin,
Galangin,
Quercetin,
Isoquercetin,
Eriodictyol,
Proanthocyanidin,
(−)-epigallocatechin-3-gallate,
Dihydromyricetin,
Soybean
Isoflavones,
Calycosin,
Icariside
II,
Safflower
Yellow,
which
shown
promising
results
models
injuries,
ischemic
stroke,
cerebral
ischemia-reperfusion
injury,
intracerebral
hemorrhage,
subarachnoid
traumatic
brain
spinal
cord
injury.
Among
these,
Baicalin
its
precursor
Baicalein
stand
out
due
extensive
research
favorable
outcomes
injury
models.
Mechanistically,
not
only
regulate
Nrf2/ARE
pathway
activate
GPX4/GSH-related
pathways
but
also
modulate
metabolism
proteins,
thereby
alleviating
overload
inhibiting
While
show
promise
especially
settings,
further
needed
evaluate
efficacy,
safety,
pharmacokinetics,
blood-brain
barrier
penetration
application.
Neuroreport,
Год журнала:
2025,
Номер
36(6), С. 327 - 335
Опубликована: Март 26, 2025
Acute
cerebral
infarction
(CI)
is
characterized
by
acute
onset,
high
disability
rate,
and
morbidity
which
seriously
threatens
the
health
safety
of
people
places
a
heavy
burden
on
individuals
country.
This
study
aimed
to
explore
effects
butylphthalide
nerve
cell
ferroptosis
in
CI
rats
its
underlying
mechanisms.
Middle
artery
occlusion
(MCAO)
rat
model
was
used
effect
vivo
oxygen
glucose
deprivation
(OGD)
vitro
.
Our
findings
demonstrated
that
markedly
reduced
oxidative
damage
brains
MCAO
rats.
Furthermore,
we
found
upregulated
netrin-1/deleted
colorectal
cancer
(DCC)/vascular
endothelial
growth
factor
(VEGF)
signaling
axis,
regulates
NF-E2-related
factor-2
(NRF2)
expression
contributes
OGD-treated
HT22
cells.
Collectively,
our
indicate
inhibits
stress-mediated
cells
modulating
netrin-1/DCC/VEGF/NRF2
axis.
In
conclusion,
results
reveal
novel
mechanism
for
protection
CIs
butylphthalide.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Aging
is
a
major
risk
factor
for
cardiovascular
diseases
(CVD),
and
mitochondrial
autophagy
impairment
considered
significant
physiological
change
associated
with
aging.
Endothelial
cells
play
crucial
role
in
maintaining
vascular
homeostasis
function,
participating
various
processes
such
as
regulating
tone,
coagulation,
angiogenesis,
inflammatory
responses.
As
aging
progresses,
endothelial
worsens,
leading
to
the
development
of
numerous
diseases.
Therefore,
vital
preventing
treating
age-related
However,
there
currently
lack
systematic
reviews
this
area.
To
address
gap,
we
have
written
review
provide
new
research
therapeutic
strategies
managing
