Journal of Diabetes & Metabolic Disorders, Год журнала: 2025, Номер 24(1)
Опубликована: Май 31, 2025
Язык: Английский
Results in Engineering, Год журнала: 2024, Номер 24, С. 102790 - 102790
Опубликована: Сен. 5, 2024
Язык: Английский
Процитировано
11
Clocks & Sleep, Год журнала: 2025, Номер 7(1), С. 13 - 13
Опубликована: Март 10, 2025
The COVID-19 outbreak has changed work organization in favor of a working from home (WH) modality. We examined the association WH during pandemic with sleep health workers public research organization. An online cross-sectional survey 2022 at National Research Council Italy collected information on sociodemographics, characteristics, and pattern compared before WH. In whole sample (n = 748), total quality did not significantly change. Excessive daytime sleepiness (EDS) decreased Total increased poor sleepers, while it good sleepers. morning chronotype was protective against worsening Risk factors were depression body weight gain These findings emphasize importance baseline shaping impact sleep.
Язык: Английский
Процитировано
1
Digital Health, Год журнала: 2025, Номер 11
Опубликована: Май 1, 2025
Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive motor impairments. Early diagnosis remains a challenge due the slow progression of symptoms limitations current diagnostic methods. Nanobiosensors, leveraging high sensitivity specificity nanotechnology, offer promising, noninvasive, cost-effective approach for detecting disease biomarkers at ultra-low concentrations. This review highlights recent advancements in nanobiosensor technology, integration gold nanoparticles, quantum dots, carbon nanotubes, which have significantly enhanced biomarker detection precision. Furthermore, it examines advantages nanobiosensors over traditional techniques, such as improved sensitivity, rapid detection, minimal invasiveness. The potential these innovative sensors revolutionize early improve patient outcomes is discussed, along with existing challenges clinical translation, stability, reproducibility, regulatory considerations. Addressing will be crucial integrating into routine practice advancing personalized medicine neurodegenerative disorders.
Язык: Английский
Процитировано
0
Expert Review of Neurotherapeutics, Год журнала: 2025, Номер unknown
Опубликована: Май 14, 2025
Optimal sleep duration is increasingly recognized as an important determinant of overall health, including cognitive functioning. Studies often report a U- or J-shaped relationship between and incident dementia deterioration, whereas long sleep, the extremes duration, transition to were particularly detrimental. In preclinical studies, partial complete deprivation produced inflammation, oxidative stress, well increased tau hyperphosphorylation amyloid-β burden. humans, although findings are less pronounced, they still highlight that transitioning excessive associated with neurodegeneration. Moreover, association complex modified by genetic, psychosocial lifestyle factors, along psychiatric somatic comorbidities. The purpose this perspective summarize current knowledge on dementia. It based literature search for meta-analyses prospective studies exposure outcome. Sleep modifiable risk factor while may be early sign Therefore, self-reported easy-to-use tool detecting individuals who at deterioration.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
Abstract Age-related sleep disruption is common in older adults. Not only does the total amount of time spent decline, but number arousals during increases with age. As important for both memory consolidation and to prevent neurodegenerative pathology, this decline and/or may underlie age-related cognitive dementias. Furthermore, treatment can improve quality life. However, few interventions have successfully reversed decline. Extracts from plant Centella asiatica demonstrated neuroprotective effects human, rodent, fly models aging diseases, a promising intervention dementias, yet little known about how these extracts affect patterns. Here, we administered water extract ( CAW) dosed or control chow male female C57BL6/J mice aged 18 months. Effects on composition were determined using electrodes that recorded EEG EMG signals. We found CAW (1000 mg/kg/day) increased REM decreased observed females, compared age- sex-matched controls. conclude food has moderate, sex-dependent effect quantity quality. Statement Significance Sleep declines age underline changes. This study botanical mice, fragmentation Whether sizes are impactful enough cognition, life, pathology could be explored future studies.
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118020 - 118020
Опубликована: Апрель 2, 2025
Язык: Английский
Процитировано
0
Poultry Science, Год журнала: 2025, Номер unknown, С. 105140 - 105140
Опубликована: Апрель 1, 2025
The rising prevalence of heat stress (HS), because global warming, presents a considerable challenge to both human and animal health welfare. L-Theanine (LTA), naturally occurring amino acid, may enhance poultry muscle yield quality, suggesting its potential application in alleviating the negative impacts HS. However, molecular mechanisms through which LTA exerts beneficial effects remain be fully understood. This study explored protective on cultured broiler skeletal cells under oxidative induced by HS, focusing involved. Our findings indicate that treatment with significantly improved cell survival, bolstered activity antioxidant enzymes, decreased reactive oxygen species (ROS) contents diminished malondialdehyde (MDA) levels HS-treated cells. Furthermore, enhanced phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) nuclear factor erythroid 2-related 2 (Nrf2) signaling pathways cells, facilitating mitochondrial biogenesis reducing apoptosis. were reduced PI3K inhibitor LY294002 or Nrf2 ML385. In conclusion, our showed protects from HS-induced damage modulating PI3K/AKT/Nrf2 pathway, positioning as promising natural for feed additives aimed at improving health.
Язык: Английский
Процитировано
0
Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2025, Номер 13(5), С. 1121 - 1121
Опубликована: Май 6, 2025
Stress and sleep share a reciprocal relationship, where chronic stress often leads to disturbances that worsen neurodegenerative psychiatric conditions. Non-neuronal cells, particularly astrocytes microglia, play critical roles in the brain’s response regulation of sleep. Astrocytes influence architecture by regulating adenosine signaling glymphatic clearance, both which can be disrupted stress, leading reduced restorative Microglia, activated under conditions, drive neuroinflammatory processes further impair exacerbate brain dysfunction. Additionally, gut–brain axis mediates interactions between sleep, inflammation, with microbial metabolites influencing neural pathways. Many these effects converge on disruption synaptic processes, such as neurotransmitter balance, plasticity, pruning, turn contribute pathophysiology disorders. This review explores how cellular systemic mechanisms stress-induced their implications for disorders, offering insights into potential therapeutic strategies targeting non-neuronal cells axis.
Язык: Английский
Процитировано
0
The Journal of Nutritional Biochemistry, Год журнала: 2025, Номер unknown, С. 109944 - 109944
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0