Unraveling the interplay between sleep, redox metabolism, and aging: implications for brain health and longevity DOI Creative Commons
Fayaz A. Mir, Arianna R. S. Lark,

Christa J. Nehs

et al.

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: May 21, 2025

The relationship between sleep and metabolism has emerged as a critical factor in aging age-related diseases, including Alzheimer’s disease dementia. Mitochondrial oxidative phosphorylation, essential for neuronal energy production, also generates reactive oxygen species (ROS), which increase with age contribute to stress. Sleep plays vital role modulating redox balance, facilitating the clearance of free radicals, supporting mitochondrial function. Disruptions are closely linked imbalances, emerging evidence suggests that pharmacological interventions, such dual orexin receptor antagonists antioxidant-based therapies, may help restore homeostasis. Furthermore, antioxidant-rich diets supplements have shown promise improving both quality metabolic health populations. Neurons, their high demands, particularly vulnerable damage, making regulation crucial maintaining brain integrity. This review explores bidirectional through five key areas: (1) sleep’s radical regulation, (2) ROS mediators disturbances, (3) feedback loops impaired metabolism, (4) sleep, redox, peripheral systems, (5) therapeutic strategies balance improve outcomes. Understanding these mechanisms provide new targets interventions aimed at mitigating age-associated diseases.

Language: Английский

Application of Nanobiosensor Engineering in the Diagnosis of Neurodegenerative Disorders DOI Creative Commons

Thikra S. Dhahi,

Alaa Kamal Yousif Dafhalla, A. Wesam Al-Mufti

et al.

Results in Engineering, Journal Year: 2024, Volume and Issue: 24, P. 102790 - 102790

Published: Sept. 5, 2024

Language: Английский

Citations

10
Not All Workers Experience Equal Sleep Changes: Insights from the “WorkInCovid” Project DOI Creative Commons
Sergio Garbarino, Antonella Bodini, Saverio Sabina

et al.

Clocks & Sleep, Journal Year: 2025, Volume and Issue: 7(1), P. 13 - 13

Published: March 10, 2025

The COVID-19 outbreak has changed work organization in favor of a working from home (WH) modality. We examined the association WH during pandemic with sleep health workers public research organization. An online cross-sectional survey 2022 at National Research Council Italy collected information on sociodemographics, characteristics, and pattern compared before WH. In whole sample (n = 748), total quality did not significantly change. Excessive daytime sleepiness (EDS) decreased Total increased poor sleepers, while it good sleepers. morning chronotype was protective against worsening Risk factors were depression body weight gain These findings emphasize importance baseline shaping impact sleep.

Language: Английский

Citations

1
Centella asiatica improves sleep quality and quantity in aged mice DOI Open Access
Laura Dovek, Carolyn E. Jones-Tinsley,

Katelyn Gutowsky

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Age-related sleep disruption is common in older adults. Not only does the total amount of time spent decline, but number arousals during increases with age. As important for both memory consolidation and to prevent neurodegenerative pathology, this decline and/or may underlie age-related cognitive dementias. Furthermore, treatment can improve quality life. However, few interventions have successfully reversed decline. Extracts from plant Centella asiatica demonstrated neuroprotective effects human, rodent, fly models aging diseases, a promising intervention dementias, yet little known about how these extracts affect patterns. Here, we administered water extract ( CAW) dosed or control chow male female C57BL6/J mice aged 18 months. Effects on composition were determined using electrodes that recorded EEG EMG signals. We found CAW (1000 mg/kg/day) increased REM decreased observed females, compared age- sex-matched controls. conclude food has moderate, sex-dependent effect quantity quality. Statement Significance Sleep declines age underline changes. This study botanical mice, fragmentation Whether sizes are impactful enough cognition, life, pathology could be explored future studies.

Language: Английский

Citations

0
Exploring the links between polyphenols, Nrf2, and diabetes: A review DOI

Reza Ebrahimi,

Alireza Mohammadpour, Alessandro Medoro

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118020 - 118020

Published: April 2, 2025

Language: Английский

Citations

0
L-Theanine attenuates oxidative damage induced by heat stress through the PI3K/AKT/Nrf2 signaling pathway in skeletal muscle cells DOI Creative Commons
Qiong Wu,

Xiaochun Wan,

Dongxu Wang

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105140 - 105140

Published: April 1, 2025

The rising prevalence of heat stress (HS), because global warming, presents a considerable challenge to both human and animal health welfare. L-Theanine (LTA), naturally occurring amino acid, may enhance poultry muscle yield quality, suggesting its potential application in alleviating the negative impacts HS. However, molecular mechanisms through which LTA exerts beneficial effects remain be fully understood. This study explored protective on cultured broiler skeletal cells under oxidative induced by HS, focusing involved. Our findings indicate that treatment with significantly improved cell survival, bolstered activity antioxidant enzymes, decreased reactive oxygen species (ROS) contents diminished malondialdehyde (MDA) levels HS-treated cells. Furthermore, enhanced phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) nuclear factor erythroid 2-related 2 (Nrf2) signaling pathways cells, facilitating mitochondrial biogenesis reducing apoptosis. were reduced PI3K inhibitor LY294002 or Nrf2 ML385. In conclusion, our showed protects from HS-induced damage modulating PI3K/AKT/Nrf2 pathway, positioning as promising natural for feed additives aimed at improving health.

Language: Английский

Citations

0
Linkage of circadian rhythm disruptions with Alzheimer’s disease and therapeutic interventions DOI Creative Commons
Kishore Madhamanchi, Jianhua Zhang, Girish C. Melkani

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Stress-Induced Sleep Dysregulation: The Roles of Astrocytes and Microglia in Neurodegenerative and Psychiatric Disorders DOI Creative Commons

Ángel R. Rábago-Monzón,

Juan Fidel Osuna‐Ramos,

David A. Armienta-Rojas

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1121 - 1121

Published: May 6, 2025

Stress and sleep share a reciprocal relationship, where chronic stress often leads to disturbances that worsen neurodegenerative psychiatric conditions. Non-neuronal cells, particularly astrocytes microglia, play critical roles in the brain’s response regulation of sleep. Astrocytes influence architecture by regulating adenosine signaling glymphatic clearance, both which can be disrupted stress, leading reduced restorative Microglia, activated under conditions, drive neuroinflammatory processes further impair exacerbate brain dysfunction. Additionally, gut–brain axis mediates interactions between sleep, inflammation, with microbial metabolites influencing neural pathways. Many these effects converge on disruption synaptic processes, such as neurotransmitter balance, plasticity, pruning, turn contribute pathophysiology disorders. This review explores how cellular systemic mechanisms stress-induced their implications for disorders, offering insights into potential therapeutic strategies targeting non-neuronal cells axis.

Language: Английский

Citations

0
Associations between flavonoids intake and sleep disorders: A survey-weighted cross-section study from NHANES DOI
Xiangjun Qi, Caishan Fang,

L. Liu

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109944 - 109944

Published: May 1, 2025

Language: Английский

Citations

0
The Cardiovascular Consequences of Chronic Sleep Fragmentation: Evidence from Experimental Models of Obstructive Sleep Apnea DOI
Mohammad Badran, Clémentine Puech, David Gozal

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 106566 - 106566

Published: May 1, 2025

Language: Английский

Citations

0
Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection DOI Creative Commons
Shikha Yadav, Sarad Pawar Naik Bukke,

Shatrudhan Prajapati

et al.

Digital Health, Journal Year: 2025, Volume and Issue: 11

Published: May 1, 2025

Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive motor impairments. Early diagnosis remains a challenge due the slow progression of symptoms limitations current diagnostic methods. Nanobiosensors, leveraging high sensitivity specificity nanotechnology, offer promising, noninvasive, cost-effective approach for detecting disease biomarkers at ultra-low concentrations. This review highlights recent advancements in nanobiosensor technology, integration gold nanoparticles, quantum dots, carbon nanotubes, which have significantly enhanced biomarker detection precision. Furthermore, it examines advantages nanobiosensors over traditional techniques, such as improved sensitivity, rapid detection, minimal invasiveness. The potential these innovative sensors revolutionize early improve patient outcomes is discussed, along with existing challenges clinical translation, stability, reproducibility, regulatory considerations. Addressing will be crucial integrating into routine practice advancing personalized medicine neurodegenerative disorders.

Language: Английский

Citations

0