Roles of anoikis in hepatocellular carcinoma: mechanisms and therapeutic potential DOI
Chen Chen, Mengyao Wang,

Daoyuan Tu

и другие.

Medical Oncology, Год журнала: 2025, Номер 42(3)

Опубликована: Янв. 30, 2025

Язык: Английский

Unveiling the mechanisms and challenges of cancer drug resistance DOI Creative Commons
Sameer Ullah Khan, Kaneez Fatima,

Shariqa Aisha

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 12, 2024

Abstract Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer strategies are evolving due to innate acquired capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ultimately enable selected cancer cells survive progress under unfavorable conditions. Although the mechanism of drug being widely studied generate new target-based drugs with better potency than existing ones. However, broader flexibility in resistance, advanced therapeutic options efficacy need be explored. Combination therapy an alternative a success rate though risk amplified side effects commonplace. Moreover, recent groundbreaking precision immune ways overcome has revolutionized anticancer greater extent only limitation individual-specific needs further attention. This review will focus on challenges opted withstand current therapies at molecular level also highlights emerging -like immunological, stem cell-based may prove have potential challenge problem resistance.

Язык: Английский

Процитировано

107

Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies DOI Creative Commons
Yan-Ruide Li, Ying Fang,

Zibai Lyu

и другие.

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Окт. 2, 2023

Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby compromising the effectiveness of cancer treatments. The reciprocal communication between microenvironment (TME) is observed, with TME providing supportive niche for CSC survival self-renewal, while CSCs, turn, influence polarization persistence TME, promoting an immunosuppressive state. Consequently, these interactions hinder efficacy current therapies, necessitating exploration novel therapeutic approaches modulate target CSCs. this review, we highlight intricate strategies employed by evade surveillance develop resistance therapies. Furthermore, examine dynamic interplay shedding light on how interaction impacts progression. Moreover, provide overview advanced that specifically which hold promise future clinical translational studies treatment.

Язык: Английский

Процитировано

71

Cancer metastasis: Molecular mechanisms and clinical perspectives DOI
Sameer Ullah Khan,

Kaneez Fatima,

Fayaz Malik

и другие.

Pharmacology & Therapeutics, Год журнала: 2023, Номер 250, С. 108522 - 108522

Опубликована: Сен. 1, 2023

Язык: Английский

Процитировано

63

Anoikis in cell fate, physiopathology, and therapeutic interventions DOI Creative Commons
Jie Mei,

Xue‐Yao Jiang,

Huixiang Tian

и другие.

MedComm, Год журнала: 2024, Номер 5(10)

Опубликована: Сен. 15, 2024

The extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with particular emphasis on anoikis, an integrin-dependent form cell death. Currently, anoikis is defined as intrinsic apoptosis. In contrast to traditional apoptosis and necroptosis, integrin correlates ECM signaling intracellular cascades, describing the full process anoikis. However, frequently overlooked in physiological pathological processes well vitro research models. this review, we summarized role spanning embryonic development, organ tissue repair, inflammatory responses, cardiovascular diseases, tumor metastasis, so on. Similarly, realm stem focused functional evolution cells, offers potential solution various challenges, including culture models, therapy, transplantation, engineering applications, which are largely based regulation by More importantly, regulatory mechanisms molecular will provide new strategies for therapeutic interventions (drug therapy cell-based therapy) disease. summary, review provides systematic elaboration thus shedding light its future research.

Язык: Английский

Процитировано

11

War or peace: Viruses and metastasis DOI
Mobina Bayat,

Shahin Golestani,

Saeed Motlaghzadeh

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(6), С. 189179 - 189179

Опубликована: Сен. 17, 2024

Язык: Английский

Процитировано

10

Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance DOI Creative Commons

Tongxuan Shang,

Ziqi Jia, J. Li

и другие.

Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)

Опубликована: Март 18, 2025

In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. Hypoxia is a key feature solid tumors strongly associated with poor prognosis in patients. Another significant portion development acquired drug attributed to tumor stemness. Cancer stem cells (CSCs), small cell subset self-renewal proliferative abilities, are crucial for initiation, metastasis, intra-tumoral heterogeneity. Studies have shown association between hypoxia CSCs context resistance. Recent studies reveal strong link stemness, which together promote survival progression during treatment. This review elucidates interplay CSCs, well their correlation therapeutic drugs. Targeting pivotal genes stemness holds promise novel therapeutics combat

Язык: Английский

Процитировано

2

CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis DOI
Tian Tian,

Yun‐Xin Lu,

Jin‐Fei Lin

и другие.

Redox Biology, Год журнала: 2022, Номер 58, С. 102544 - 102544

Опубликована: Ноя. 16, 2022

Язык: Английский

Процитировано

38

Redox balance and autophagy regulation in cancer progression and their therapeutic perspective DOI
Sameer Ullah Khan, Kaneez Fatima,

Shariqa Aisha

и другие.

Medical Oncology, Год журнала: 2022, Номер 40(1)

Опубликована: Ноя. 9, 2022

Язык: Английский

Процитировано

33

Lavender Plant: Farming and Health Benefits DOI
Sameer Ullah Khan,

Baseerat Hamza,

Reyaz Hassan Mir

и другие.

Current Molecular Medicine, Год журнала: 2023, Номер 24(6), С. 702 - 711

Опубликована: Май 19, 2023

Abstract: Natural remedies from a range of sources, including plants, animals, microorganisms, and marine life, have made significant contribution to the treatment many ailments. Lavender is Mediterranean shrub Lamiaceae family. flowers (Lavandula flores) include active ingredients (3%), anthocyanins, sugars, phytosterols, minerals, tannins are majorly used for herbal applications. essential oil's descriptive analytical composition varies depending on genotype, growing region, climatic circumstances, propagation, morphological characteristics. There around 300 chemical components in oil. Linalool, terpinen-4-ol, linalyl acetate, ocimene, acetate lavandulol, cineole most prominent constituents. oil has antibacterial antioxidant properties. The lavender extract helps prevent dementia may slow cancer cell growth, while treat skin problems. This review will cover recent medical, economic regional advancements levander propagation how Council Scientific & Industrial Research Indian Institute Integrative (CSIR IIIM) aroma mission actively acting as bridge between farmers their improvement by attracting them field medicinal plant cultivation.

Язык: Английский

Процитировано

23

Metastatic outgrowth via the two-way interplay of autophagy and metabolism DOI Creative Commons
Amir Barzegar Behrooz, Marco Cordani, Massimo Donadelli

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2023, Номер 1870(3), С. 166824 - 166824

Опубликована: Ноя. 9, 2023

Язык: Английский

Процитировано

22