Medical Oncology, Год журнала: 2025, Номер 42(3)
Опубликована: Янв. 30, 2025
Язык: Английский
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Фев. 12, 2024
Abstract Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer strategies are evolving due to innate acquired capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ultimately enable selected cancer cells survive progress under unfavorable conditions. Although the mechanism of drug being widely studied generate new target-based drugs with better potency than existing ones. However, broader flexibility in resistance, advanced therapeutic options efficacy need be explored. Combination therapy an alternative a success rate though risk amplified side effects commonplace. Moreover, recent groundbreaking precision immune ways overcome has revolutionized anticancer greater extent only limitation individual-specific needs further attention. This review will focus on challenges opted withstand current therapies at molecular level also highlights emerging -like immunological, stem cell-based may prove have potential challenge problem resistance.
Язык: Английский
Процитировано
107
Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)
Опубликована: Окт. 2, 2023
Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby compromising the effectiveness of cancer treatments. The reciprocal communication between microenvironment (TME) is observed, with TME providing supportive niche for CSC survival self-renewal, while CSCs, turn, influence polarization persistence TME, promoting an immunosuppressive state. Consequently, these interactions hinder efficacy current therapies, necessitating exploration novel therapeutic approaches modulate target CSCs. this review, we highlight intricate strategies employed by evade surveillance develop resistance therapies. Furthermore, examine dynamic interplay shedding light on how interaction impacts progression. Moreover, provide overview advanced that specifically which hold promise future clinical translational studies treatment.
Язык: Английский
Процитировано
71
Pharmacology & Therapeutics, Год журнала: 2023, Номер 250, С. 108522 - 108522
Опубликована: Сен. 1, 2023
Язык: Английский
Процитировано
63
MedComm, Год журнала: 2024, Номер 5(10)
Опубликована: Сен. 15, 2024
The extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with particular emphasis on anoikis, an integrin-dependent form cell death. Currently, anoikis is defined as intrinsic apoptosis. In contrast to traditional apoptosis and necroptosis, integrin correlates ECM signaling intracellular cascades, describing the full process anoikis. However, frequently overlooked in physiological pathological processes well vitro research models. this review, we summarized role spanning embryonic development, organ tissue repair, inflammatory responses, cardiovascular diseases, tumor metastasis, so on. Similarly, realm stem focused functional evolution cells, offers potential solution various challenges, including culture models, therapy, transplantation, engineering applications, which are largely based regulation by More importantly, regulatory mechanisms molecular will provide new strategies for therapeutic interventions (drug therapy cell-based therapy) disease. summary, review provides systematic elaboration thus shedding light its future research.
Язык: Английский
Процитировано
11
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(6), С. 189179 - 189179
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
10
Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)
Опубликована: Март 18, 2025
In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. Hypoxia is a key feature solid tumors strongly associated with poor prognosis in patients. Another significant portion development acquired drug attributed to tumor stemness. Cancer stem cells (CSCs), small cell subset self-renewal proliferative abilities, are crucial for initiation, metastasis, intra-tumoral heterogeneity. Studies have shown association between hypoxia CSCs context resistance. Recent studies reveal strong link stemness, which together promote survival progression during treatment. This review elucidates interplay CSCs, well their correlation therapeutic drugs. Targeting pivotal genes stemness holds promise novel therapeutics combat
Язык: Английский
Процитировано
2
Redox Biology, Год журнала: 2022, Номер 58, С. 102544 - 102544
Опубликована: Ноя. 16, 2022
Язык: Английский
Процитировано
38
Medical Oncology, Год журнала: 2022, Номер 40(1)
Опубликована: Ноя. 9, 2022
Язык: Английский
Процитировано
33
Current Molecular Medicine, Год журнала: 2023, Номер 24(6), С. 702 - 711
Опубликована: Май 19, 2023
Abstract: Natural remedies from a range of sources, including plants, animals, microorganisms, and marine life, have made significant contribution to the treatment many ailments. Lavender is Mediterranean shrub Lamiaceae family. flowers (Lavandula flores) include active ingredients (3%), anthocyanins, sugars, phytosterols, minerals, tannins are majorly used for herbal applications. essential oil's descriptive analytical composition varies depending on genotype, growing region, climatic circumstances, propagation, morphological characteristics. There around 300 chemical components in oil. Linalool, terpinen-4-ol, linalyl acetate, ocimene, acetate lavandulol, cineole most prominent constituents. oil has antibacterial antioxidant properties. The lavender extract helps prevent dementia may slow cancer cell growth, while treat skin problems. This review will cover recent medical, economic regional advancements levander propagation how Council Scientific & Industrial Research Indian Institute Integrative (CSIR IIIM) aroma mission actively acting as bridge between farmers their improvement by attracting them field medicinal plant cultivation.
Язык: Английский
Процитировано
23
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2023, Номер 1870(3), С. 166824 - 166824
Опубликована: Ноя. 9, 2023
Язык: Английский
Процитировано
22