Unveiling the mechanisms and challenges of cancer drug resistance

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 12, 2024

Abstract Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer strategies are evolving due to innate acquired capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ultimately enable selected cancer cells survive progress under unfavorable conditions. Although the mechanism of drug being widely studied generate new target-based drugs with better potency than existing ones. However, broader flexibility in resistance, advanced therapeutic options efficacy need be explored. Combination therapy an alternative a success rate though risk amplified side effects commonplace. Moreover, recent groundbreaking precision immune ways overcome has revolutionized anticancer greater extent only limitation individual-specific needs further attention. This review will focus on challenges opted withstand current therapies at molecular level also highlights emerging -like immunological, stem cell-based may prove have potential challenge problem resistance.

Язык: Английский

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Cancer metastasis: Molecular mechanisms and clinical perspectives

Pharmacology & Therapeutics, Год журнала: 2023, Номер 250, С. 108522 - 108522

Опубликована: Сен. 1, 2023

Язык: Английский

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Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions

Antioxidants, Год журнала: 2023, Номер 12(2), С. 428 - 428

Опубликована: Фев. 9, 2023

Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or maintain homeostasis survival. It typically observed nutrient-deprived cells as survival mechanism. However, it has also been identified crucial maintaining disease progression. Normal metabolism produces reactive oxygen (ROS) nitrogen species at low levels. increased production causes oxidative stress, can lead diabetes, cardiovascular diseases, neurological disorders, cancer. was recently shown that redox equilibrium via autophagy critical for responses stress. little understood about the molecular cancer processes connect control of autophagy. In cells, oncogenic mutations, carcinogens, metabolic reprogramming cause ROS generation Recent studies have suggested activates pathways promote development metastasis. Moreover, relationship between programming involved malignant phenotype. Currently, while signaling events governing how affects cascades well understood, very known related this review, we focus on current knowledge modulation role further stress progression regulation. Therefore, review focuses understanding oxidation/reduction fine-tune help understand govern cancer, either leading cell death strategies

Язык: Английский

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Lavender Plant: Farming and Health Benefits

Current Molecular Medicine, Год журнала: 2023, Номер 24(6), С. 702 - 711

Опубликована: Май 19, 2023

Abstract: Natural remedies from a range of sources, including plants, animals, microorganisms, and marine life, have made significant contribution to the treatment many ailments. Lavender is Mediterranean shrub Lamiaceae family. flowers (Lavandula flores) include active ingredients (3%), anthocyanins, sugars, phytosterols, minerals, tannins are majorly used for herbal applications. essential oil's descriptive analytical composition varies depending on genotype, growing region, climatic circumstances, propagation, morphological characteristics. There around 300 chemical components in oil. Linalool, terpinen-4-ol, linalyl acetate, ocimene, acetate lavandulol, cineole most prominent constituents. oil has antibacterial antioxidant properties. The lavender extract helps prevent dementia may slow cancer cell growth, while treat skin problems. This review will cover recent medical, economic regional advancements levander propagation how Council Scientific & Industrial Research Indian Institute Integrative (CSIR IIIM) aroma mission actively acting as bridge between farmers their improvement by attracting them field medicinal plant cultivation.

Язык: Английский

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Antioxidant Activity of Panax ginseng to Regulate ROS in Various Chronic Diseases

Applied Sciences, Год журнала: 2023, Номер 13(5), С. 2893 - 2893

Опубликована: Фев. 23, 2023

Reactive oxygen species (ROS)-the byproduct of regular cell activity formed by various cellular components—play a significant role in pathological and physiological conditions. Alternatively, antioxidants are compounds that reduce or scavenge reactive cells. An asymmetry between the antioxidant defense system ROS from intracellular extracellular sources cause chronic diseases such as cancer, inflammation, tumorigenesis, cardiovascular neurogenerative diseases. However, Panax ginseng its secondary metabolites (known ginsenosides, phenolic compounds, peptides, acid polysaccharides, polyacetylene, alkaloids) well-recognized many vitro vivo experiments which show beneficial regulating these There extensive evidences P. can destroy cancer cells specifically increasing oxidative stress through generation without significantly harming normal Additionally, numerous studies have examined derivatives on ROS-mediated signaling pathways discussed herein. This review summarizes potential several diseases, gives updated research evidence with related mechanisms future possibilities nano-formulated other polyphenols.

Язык: Английский

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Effect of N-Acetylcysteine on Cisplatin Toxicity: A Review of the Literature

Biologics, Год журнала: 2024, Номер Volume 18, С. 7 - 19

Опубликована: Янв. 1, 2024

Abstract: N-acetylcysteine (NAC) is a membrane-permeable cysteine precursor capable of enhancing the intracellular pool, cellular glutathione (GSH) synthesis, and thus potentiating endogenous antioxidant mechanism. Late administration NAC after cisplatin has been shown in different vivo studies to reduce side effects caused by various toxicities at levels without affecting antitumor efficacy platinum, improving total enzymatic capacity decreasing oxidative stress markers. These characteristics provide with rationale as potentially effective chemo protectant cisplatin-based therapeutic cycles. represents potential candidate chemoprotective agent decrease secondary treatment. It suggests that it could be used clinical trials, whereby dose, timing, route should adjusted optimize chemoprotection. This review provides an overview effect on toxicity, drug widely clinic adults children. Keywords: cisplatin, protectant, stress,

Язык: Английский

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Targeting redox regulation and autophagy systems in cancer stem cells

Clinical and Experimental Medicine, Год журнала: 2022, Номер 23(5), С. 1405 - 1423

Опубликована: Дек. 6, 2022

Язык: Английский

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Small molecule ‘4ab’ induced autophagy and endoplasmic reticulum stress-mediated death of aggressive cancer cells grown under adherent and floating conditions

Medical Oncology, Год журнала: 2023, Номер 40(4)

Опубликована: Март 20, 2023

Язык: Английский

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Knowledge map of programmed cell death in esophageal cancer: a bibliometric analysis

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 24, 2025

This study aimed to delineate the evolving knowledge structure of programmed cell death in esophageal cancer and identify key thematic trends, influential collaborations, emerging areas for future research. A bibliometric approach was applied 2677 publications retrieved from Web Science Core Collection (2000-2024). Three complementary tools-CiteSpace, VOSviewer, bibliometrix-were employed visualize co-citation networks, detect citation bursts, map collaborative patterns among authors, institutions, countries. Inclusion criteria focused on articles reviews that addressed conjunction with apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, or related pathways. Publication outputs grew markedly, reflecting a shift early investigations basic apoptotic mechanisms broader explorations ferroptosis. China led publication volume citations, driven by substantial governmental funding large clinical cohorts. The United States Japan also contributed significantly, forming international research networks spanned Asia Europe. Leading particularly Zhengzhou University, demonstrated extensive collaborations. Journals such as Oncology Letters Reports were prominent outlets new findings, while highly cited references highlighted hypoxia, immune checkpoint blockade, gene-editing strategies. Keyword analyses revealed ascendance immuno-oncology, network pharmacology, translational applications targeting multiple regulated Bibliometric evidence underscores rapid expansion multidisciplinary integrates diverse pathways cancer. Continued leveraging advanced genomics immunologic strategies, are poised accelerate breakthroughs enable more personalized, effective therapies.

Язык: Английский

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Detection of circulating tumor cells that predicts the efficacy of neoadjuvant chemotherapy for locally advanced triple-negative breast cancer

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 30, 2025

This study aims to assess the predictive potential of circulating tumor cells (CTCs) and stem (CTSCs) in locally advanced triple-negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy (NAC) compared RECIST 1.1 standard. We analyzed 112 patients with TNBC at Liaoning Tumor Hospital. CTCs CTSCs were evaluated before NAC, on first NAC cycle day, after NAC. assessed ability positive predict resistance (requiring regimen change) a 91% specificity. Additionally, we CTC dynamics during efficacy (often reaching MP4 or MP5) 87% sensitivity 80% Positive post-first predicted high specificity (91%). The gradual decline indicated efficacy, allowing continue 80%. suggests that resistance, thereby facilitating early detection (≥ 6 weeks earlier than RECIST). Gradual reduction predicts enabling continuation. show promise as markers for TNBC.

Язык: Английский

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