Gut Microbiome: Profound Implications for Diet and Disease

Nutrients, Год журнала: 2019, Номер 11(7), С. 1613 - 1613

Опубликована: Июль 16, 2019

The gut microbiome plays an important role in human health and influences the development of chronic diseases ranging from metabolic disease to gastrointestinal disorders colorectal cancer. Of increasing prevalence Western societies, these conditions carry a high burden care. Dietary patterns environmental factors have profound effect on shaping microbiota real time. Diverse populations intestinal bacteria mediate their beneficial effects through fermentation dietary fiber produce short-chain fatty acids, endogenous signals with roles lipid homeostasis reducing inflammation. Recent progress shows that individual's starting microbial profile is key determinant predicting response intervention live probiotics. complex challenging characterize. Enterotypes been proposed using metrics such as alpha species diversity, ratio Firmicutes Bacteroidetes phyla, relative abundance genera (e.g., Bifidobacterium, Akkermansia) versus facultative anaerobes (E. coli), pro-inflammatory Ruminococcus, or nonbacterial microbes. Microbiota composition bacterial are linked physiologic along different axes. We review diet quality, carbohydrate intake, fermentable FODMAPs, prebiotic maintaining healthy flora. implications discussed for various including obesity, diabetes, irritable bowel syndrome, inflammatory disease, depression, cardiovascular disease.

Язык: Английский

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Objectives, design and main findings until 2020 from the Rotterdam Study

European Journal of Epidemiology, Год журнала: 2020, Номер 35(5), С. 483 - 517

Опубликована: Май 1, 2020

The Rotterdam Study is an ongoing prospective cohort study that started in 1990 the city of Rotterdam, Netherlands. aims to unravel etiology, preclinical course, natural history and potential targets for intervention chronic diseases mid-life late-life. focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. Since 2016, being expanded by persons 40 over. findings have been presented 1700 research articles reports. This article provides update rationale design study. It also presents a summary major from preceding 3 outlines developments coming period.

Язык: Английский

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Coffee, Caffeine, and Health

New England Journal of Medicine, Год журнала: 2020, Номер 383(4), С. 369 - 378

Опубликована: Июль 22, 2020

In many countries, a large majority of adults consume caffeine daily. This review summarizes the evidence about varied physiological effects and coffee risks cardiovascular disease, insulin resistance, gallstones, cancer, liver disease.

Язык: Английский

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The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease

Purinergic Signalling, Год журнала: 2020, Номер 16(2), С. 167 - 174

Опубликована: Март 31, 2020

Язык: Английский

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Coffee and tea on cardiovascular disease (CVD) prevention

Trends in Cardiovascular Medicine, Год журнала: 2021, Номер 32(7), С. 399 - 405

Опубликована: Авг. 9, 2021

Язык: Английский

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Association of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific Mortality

Annals of Internal Medicine, Год журнала: 2022, Номер 175(7), С. 909 - 917

Опубликована: Май 30, 2022

Background: Previous observational studies have suggested an association between coffee intake and reduced risk for death, but these did not distinguish consumed with sugar or artificial sweeteners without. Objective: To evaluate the associations of consumption sugar-sweetened, artificially sweetened, unsweetened all-cause cause-specific mortality. Design: Prospective cohort study. Setting: Data were extracted from UK Biobank. Participants: A total 171 616 participants (mean age, 55.6 years [SD, 7.9]) without cardiovascular disease (CVD) cancer at baseline eligible. Baseline demographic, lifestyle, dietary data Biobank used, follow-up beginning in 2009 ending 2018. Measurements: Dietary was self-reported. All-cause, cancer-related, CVD-related mortality estimated. Results: During a median 7.0 years, 3177 deaths recorded (including 1725 628 CVD deaths). Cox models penalized splines showed U-shaped coffee, sugar-sweetened sweetened Compared nonconsumers, consumers various amounts (>0 to 1.5, >1.5 2.5, >2.5 3.5, >3.5 4.5, >4.5 drinks/d) had lower risks after adjustment sociodemographic, clinical factors, respective hazard ratios 0.79 (95% CI, 0.70 0.90), 0.84 (CI, 0.74 0.95), 0.71 0.62 0.82), 0.60 0.84), 0.77 0.65 0.91); estimates 0.91 0.78 1.07), 0.69 0.57 0.72 0.91), 1.06), 1.05 0.82 1.36). The less consistent. drinking largely consistent that also observed instant, ground, decaffeinated coffee. Limitation: Exposure assessed might capture changes over time. Conclusion: Moderate associated death. Primary Funding Source: National Natural Science Foundation China, Young Elite Scientist Sponsorship Program by CAST, Project Supported Guangdong Basic Applied Research Foundation.

Язык: Английский

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Beverage consumption and mortality among adults with type 2 diabetes: prospective cohort study

BMJ, Год журнала: 2023, Номер unknown, С. e073406 - e073406

Опубликована: Апрель 19, 2023

To investigate the intake of specific types beverages in relation to mortality and cardiovascular disease (CVD) outcomes among adults with type 2 diabetes.

Язык: Английский

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Diet strategies for promoting healthy aging and longevity: An epidemiological perspective

Journal of Internal Medicine, Год журнала: 2023, Номер 295(4), С. 508 - 531

Опубликована: Окт. 23, 2023

Abstract In recent decades, global life expectancies have risen significantly, accompanied by a marked increase in chronic diseases and population aging. This narrative review aims to summarize findings on the dietary factors influencing longevity, primarily from large cohort studies. First, maintaining healthy weight throughout is pivotal for aging mirroring benefits of lifelong, moderate calorie restriction today's obesogenic food environment. Second, specific types or sources fat, protein, carbohydrates are more important disease risk mortality than their quantity. Third, some traditional diets (e.g., Mediterranean, Nordic, Okinawa) contemporary patterns, such as plant‐based diet index, DASH (dietary approaches stop hypertension) diet, alternate eating been associated with lower longevity. These patterns share many common components predominance nutrient‐rich plant foods; limited red processed meats; culinary herbs spices prevalent cuisines) while embracing distinct elements different cultures. Fourth, combining other lifestyle could extend disease‐free 8–10 years. While adhering core principles diets, it crucial adapt recommendations individual preferences cultures well nutritional needs populations. Public health strategies should aim create healthier environment where nutritious options readily accessible, especially public institutions care facilities elderly. Although further mechanistic studies human trials needed better understand molecular effects aging, there pressing need establish maintain long‐term cohorts studying culturally diverse

Язык: Английский

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Coffee consumption, health benefits and side effects: a narrative review and update for dietitians and nutritionists

Critical Reviews in Food Science and Nutrition, Год журнала: 2021, Номер 63(9), С. 1238 - 1261

Опубликована: Авг. 28, 2021

Coffee is one of the most popular beverages worldwide; however, its impact on health outcomes and adverse effects not fully understood. The current review aims to establish an update about benefits coffee consumption highlighting side effects, finally coming up with attempt provide some recommendations doses. A literature using PubMed/Medline database was carried out data were summarized by applying a narrative approach available evidence based literature. main findings following: first, may contribute prevention inflammatory oxidative stress-related diseases, such as obesity, metabolic syndrome type 2 diabetes; second, seems be associated lower incidence several types cancer reduction in risk all-cause mortality; finally, 400 mg/day (1-4 cups per day) caffeine safe. However, time gap between drugs should taken into account order avoid interaction. cross-sectional or/and observational studies association intake outcomes; thus, randomized controlled are needed identify causality link.

Язык: Английский

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Gut Microbiome: Profound Implications for Diet and Disease

Kompass Nutrition & Dietetics, Год журнала: 2022, Номер unknown, С. 1 - 16

Опубликована: Апрель 7, 2022

The gut microbiome plays an important role in human health and influences the development of chronic diseases ranging from metabolic disease to gastrointestinal disorders colorectal cancer. Of increasing prevalence Western societies, these conditions carry a high burden care. Dietary patterns environmental factors have profound effect on shaping microbiota real time. Diverse populations intestinal bacteria mediate their beneficial effects through fermentation dietary fiber produce short-chain fatty acids, endogenous signals with roles lipid homeostasis reducing inflammation. Recent progress shows that individual’s starting microbial profile is key determinant predicting response intervention live probiotics. complex challenging characterize. Enterotypes been proposed using metrics such as alpha species diversity, ratio Firmicutes Bacteroidetes phyla, relative abundance genera (e.g., <i>Bifidobacterium</i>, <i>Akkermansia</i>) versus facultative anaerobes (<i>E. coli</i>), pro-inflammatory <i>Ruminococcus</i>, or nonbacterial microbes. Microbiota composition bacterial are linked physiolog­ic along different axes. We review diet quality, carbohydrate intake, fermentable FODMAPs, prebiotic maintaining healthy flora. implications discussed for various including obesity, diabetes, irritable bowel syndrome, inflammatory disease, depression, cardiovascular disease.

Язык: Английский

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