Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings

Molecules, Год журнала: 2023, Номер 28(9), С. 3669 - 3669

Опубликована: Апрель 23, 2023

Geraniol (GNL), a natural monoterpene, is found in many essential oils of fruits, vegetables, and herbs, including lavender, citronella, lemongrass, other medicinal aromatic plants. GNL commonly used by the cosmetic food industries has shown wide spectrum pharmacological activities anti-inflammatory, anticancer, antimicrobial, antioxidant, neuroprotective activities. It represents potential anti-inflammatory agent promising cancer chemopreventive agent, as it been to be effective against broad range cancers, colon, prostate, breast, lung, skin, kidney, liver, pancreatic cancer. Moreover, scavenges free radicals preserves activity antioxidant enzymes. In addition, induces apoptosis cell cycle arrest, modulates multiple molecular targets, p53 STAT3, activates caspases, inflammation via transcriptional regulation. present study, different modes action are described for GNL’s inflammatory diseases. This compound protects various enzymes, such catalase, glutathione-S-transferase, glutathione peroxidase. Experiments using allergic encephalomyelitis, diabetes, asthma, carcinogenesis models showed that treatment had beneficial effects with low toxicity. animal tumor lines, but there have not any clinical studies carried out it. The aim review provide updated data on inflammation, enhance our understanding involved pathways, possible use therapeutic purposes inflammation-related

Язык: Английский

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Preparation and characterization of geraniol nanoemulsions and its antibacterial activity

Frontiers in Microbiology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 29, 2022

Geraniol nanoemulsions (G-NE) based on Tween 80 and medium chain triglyceride (MCT) as surfactant co-surfactant, respectively, has been prepared by the spontaneous emulsification method. Its physical chemical properties such mean particle size, zeta potential, PDI, pH, viscosity, contact angle, appearance morphology, stability (storage stability, thermal centrifugal properties, acid-base freeze-thaw properties) of droplet were analyzed. The results showed that size G-NE was 90.33 ± 5.23 nm, PDI 0.058 0.0007, potential −17.95 5.85 mV encapsulation efficiency >90%. produced demonstrated to be fairly stable in long-term storage at 4°C, pH = 5 high-speed centrifuges. Moreover, had a significant inhibition effect Staphylococcus aureus , Escherichia coli Salmonella typhimurium Listeria monocytogenes ( p < 0.05 ). bacterial rates concentration 1 MIC 48, 99, 71.73, 99% after 12 h action against these four foodborne pathogenic bacteria, respectively. Therefore, obtained indicated nanoemulsification enhanced antibacterial activity geraniol some extent, which will promote utilization food preservation.

Язык: Английский

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Optimization of solvent-free microwave extraction of essential oil from the fresh peel of Citrus medica L. var. arcodactylis Swingle by response surface methodology, chemical composition and activity characterization

Scientia Horticulturae, Год журнала: 2022, Номер 309, С. 111663 - 111663

Опубликована: Ноя. 1, 2022

Язык: Английский

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A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia

Biomedicines, Год журнала: 2023, Номер 11(9), С. 2413 - 2413

Опубликована: Авг. 29, 2023

Sickle cell anaemia (SCD) is a life-threatening haematological disorder which predominant in sub-Saharan Africa and triggered by genetic mutation of the β-chain haemoglobin gene resulting substitution glutamic acid with valine. This leads to production an abnormal molecule called S (HbS). When deoxygenated, (HbS) polymerises results sickle-shaped red blood rigid has significantly shortened life span. Various reports have shown strong link between oxidative stress, inflammation, immune response, pathogenesis sickle disease. The consequence these processes development vasculopathy (disease vessels) several other complications. role system, particularly innate SCD become increasingly clear recent years research; however, little known about roles adaptive system this review examines interaction transfusion, their effects on anaemia.

Язык: Английский

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Chitosan-loaded piperlongumine nanoparticles and kaempferol enhance the anti-cancer action of doxorubicin in targeting of Ehrlich solid adenocarcinoma: in vivo and in silico modeling study

Medical Oncology, Год журнала: 2024, Номер 41(2)

Опубликована: Янв. 23, 2024

Abstract Doxorubicin is a chemotherapeutic drug that generates free radical-induced toxicities. Natural agents are used to potentiate or ameliorate the toxicity of chemotherapy. None studies investigating whether antioxidants prooxidants should be with chemotherapy have addressed their efficacy in same study. Therefore, aim this study was investigate potential synergy between doxorubicin and two natural rarely vivo studied anticancer agents; antioxidant “Kaempferol” prooxidant “Piperlongumine” Ehrlich tumor mice model. 77 albino were divided into 11 groups; ascites carcinoma cells injected intramuscularly develop solid tumors. After 14 days, intratumoral injections single combinations Chitosan nanoparticles loaded doxorubicin, Piperlongumine, Kaempferol performed. Tumor Characterization measured, tumors histopathologically examined evaluation expression for cancer-related genes by real-time PCR. In silico molecular docking performed uncover novel targets Piperlongumine Kaempferol. Despite receiving half overall dose compared drugs, combined doxorubicin/ piperlongumine-chitosan treatment most efficient reducing volume; down-regulating Cyclin D1 , BCL2; as well Beclin-1, Cyclophilin A modulating growth, apoptosis, autophagy, metastasis, respectively; up-regulating Glutathione peroxidase defense mechanism protecting from oxidative damage. When effective against However, combination Piperlongumine-loaded chitosan significantly enhanced its effect compounds.

Язык: Английский

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Lippia alba essential oil: A powerful and valuable antinociceptive and anti-inflammatory medicinal plant from Brazil

Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118459 - 118459

Опубликована: Июнь 18, 2024

Язык: Английский

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Pioglitazone attenuates tamoxifen-induced liver damage in rats via modulating Keap1/Nrf2/HO-1 and SIRT1/Notch1 signaling pathways: In-vivo investigations, and molecular docking analysis

Molecular Biology Reports, Год журнала: 2023, Номер 50(12), С. 10219 - 10233

Опубликована: Ноя. 7, 2023

Tamoxifen (TAM) is a chemotherapeutic drug widely utilized to treat breast cancer. On the other hand, it exerts deleterious cellular effects in clinical applications as an antineoplastic agent, such liver damage and cirrhosis. TAM-induced hepatic toxicity mainly attributed oxidative stress inflammation. Pioglitazone (PIO), peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, diabetes mellitus type-2. PIO has been reported exert anti-inflammatory antioxidant different tissues. This research assessed impact of against intoxication.Rats received (10 mg/kg) TAM (45 orally for 10 days.TAM increased aspartate aminotransferase (AST) alanine (ALT), triggered several histopathological alterations, NF-κB p65, stress, pro-inflammatory cytokines. protects dysfunction, reduced malondialdehyde (MDA), markers along with improved antioxidants. Moreover, PIO, Bcl-2 expression while reducing Bax caspase-3 levels. In addition, decreased Keap-1, Notch1, Hes-1 upregulated HO-1, Nrf2, SIRT1. Molecular docking showed binding affinity NF-κB, SIRT1.PIO mitigated hepatotoxicity by decreasing apoptosis, inflammation, stress. The protecting ability was accompanied Keap-1 regulating Keap1/Nrf2/HO-1 Sirt1/Notch1 signaling. A schematic diagram illustrating protective effect hepatotoxicity. prevented injury Nrf2/HO-1 SIRT1/Notch1 signaling mitigating apoptosis.

Язык: Английский

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Monoterpene antifungal activities: evaluating geraniol, citronellal, and linalool on Candida biofilm, host inflammatory responses, and structure–activity relationships

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 19, 2024

Despite the rising concern with fungal resistance, a myriad of molecules has yet to be explored. Geraniol, linalool, and citronellal are monoterpenes same molecular formula (C

Язык: Английский

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A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle cell Anaemia

Опубликована: Июль 17, 2023

Abstract Sickle cell anaemia (SCD) is a life-threatening haematological disorder which predominant in sub-Saharan Africa and triggered by genetic mutation of the β-chain haemoglobin gene resulting substitution glutamic acid with valine. This leads to production an abnormal molecule called S (HbS). When deoxygenated, (HbS) polymerizes results sickle-shaped red blood rigid has significantly shortened life span. Various reports have shown strong link between oxidative stress, inflammation, immune response, pathogenesis sickle disease. The consequence these processes lead development vasculopathy (disease vessels) several other complications. role system, particularly innate SCD become increasingly clear recent years research, However, little known about roles adaptive system this review examines interaction transfusion, their effects on

Язык: Английский

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Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Planta Medica, Год журнала: 2023, Номер 90(02), С. 111 - 125

Опубликована: Ноя. 7, 2023

Abstract Seborrheic dermatitis is a chronic inflammatory disease caused by Malassezia yeast species that affects the regions of body where sebaceous glands are present. The combined use different essential oils (EOs) can increase their spectrum action. Thus, present study aimed to evaluate action EOs alone and in combination with each other on M. furfur, planktonic biofilm form, anti-inflammatory mutagenic potential, addition effects viability cells lines. Of 40 evaluated EOs, 22 showed activity against furfur at 0.5 – 2.0 mg/mL concentrations. Among most active species, blend (BEOs) composed Cymbopogon martini (Roxb.) Will. Watson (MIC = mg/mL) Mentha × piperita L. 1.0 was selected, which synergistic effect when through checkerboard assay. fungicidal maintained oil from Varronia curassavica Jacq. BEOs. BEOs also inhibition formation eradication formed being superior fluconazole. Furthermore, it did not show potential interfere cell both lines (HaCaT BMDMs). TNF-α levels were reduced only C. martini; however, this property evaluating had no IL-8 levels. may be indicated for alternative treatments seborrheic dermatitis.

Язык: Английский

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