Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions
Nutrients,
Год журнала:
2024,
Номер
16(2), С. 258 - 258
Опубликована: Янв. 15, 2024
Sickle
cell
disease
(SCD),
a
distinctive
and
often
overlooked
illness
in
the
21st
century,
is
congenital
blood
disorder
characterized
by
considerable
phenotypic
diversity.
It
comprises
group
of
disorders,
with
sickle
anemia
(SCA)
being
most
prevalent
serious
genotype.
Although
there
have
been
some
systematic
reviews
global
data,
worldwide
statistics
regarding
SCD
prevalence,
morbidity,
mortality
remain
scarce.
In
developed
countries
lower
number
patients,
cutting-edge
technologies
led
to
development
new
treatments.
However,
developing
settings
where
(SCD)
more
prevalent,
medical
management,
rather
than
cure,
still
relies
on
use
hydroxyurea,
transfusions,
analgesics.
This
that
affects
red
cells,
consequently
affecting
organs
diverse
manners.
We
discuss
its
etiology
advent
technologies,
but
aim
this
study
understand
various
types
nutrition-related
studies
involving
individuals
suffering
from
SCD,
particularly
Africa.
The
interplay
environment,
food,
gut
microbiota,
along
their
respective
genomes
collectively
known
as
microbiome,
host
metabolism
responsible
for
mediating
metabolic
phenotypes
modulating
microbiota.
addition,
it
serves
purpose
providing
essential
nutrients.
Moreover,
engages
direct
interactions
homeostasis
immune
system,
well
indirect
via
metabolites.
Nutrition
interventions
nutritional
care
are
mechanisms
addressing
increased
nutrient
expenditures
important
aspects
supportive
management
patients
SCD.
Underprivileged
areas
Sub-Saharan
Africa
should
be
accompanied
efforts
define
promote
Their
importance
key
maintaining
well-being
quality
life,
especially
because
products
limited,
while
native
medicinal
plant
resources
acknowledged.
Язык: Английский
Crosstalk Between Sickle Cell Disease and Ferroptosis
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3675 - 3675
Опубликована: Апрель 13, 2025
Sickle
cell
disease
(SCD)
is
an
inherited
hemoglobin
disorder
that
widespread
across
the
globe.
It
characterized
by
a
very
complex
pathogenesis,
but
at
basis
of
mutation
HBB
gene,
which
determines
production
mutated
hemoglobin:
sickle
(HbS).
The
polymerization
HbS,
occurs
when
protein
in
deoxygenated
state,
and
greater
fragility
red
blood
cells
(sRBCs)
determine
release
iron,
free
heme,
HbS
blood,
favoring
oxidative
stress
reactive
oxygen
species
(ROS).
These
features
are
common
to
new
model
death
known
as
ferroptosis,
increase
iron
ROS
concentrations
inhibition
glutathione
peroxidase
4
(GPx4)
System
Xc−.
In
this
context,
review
aims
discuss
potential
molecular
biochemical
pathways
ferroptosis
involved
SCD,
aiming
highlight
possible
tags
treating
inhibiting
ferroptosis.
Язык: Английский
A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle cell Anaemia
Опубликована: Июль 17, 2023
Abstract
Sickle
cell
anaemia
(SCD)
is
a
life-threatening
haematological
disorder
which
predominant
in
sub-Saharan
Africa
and
triggered
by
genetic
mutation
of
the
β-chain
haemoglobin
gene
resulting
substitution
glutamic
acid
with
valine.
This
leads
to
production
an
abnormal
molecule
called
S
(HbS).
When
deoxygenated,
(HbS)
polymerizes
results
sickle-shaped
red
blood
rigid
has
significantly
shortened
life
span.
Various
reports
have
shown
strong
link
between
oxidative
stress,
inflammation,
immune
response,
pathogenesis
sickle
disease.
The
consequence
these
processes
lead
development
vasculopathy
(disease
vessels)
several
other
complications.
role
system,
particularly
innate
SCD
become
increasingly
clear
recent
years
research,
However,
little
known
about
roles
adaptive
system
this
review
examines
interaction
transfusion,
their
effects
on
Язык: Английский
Evaluating the Diagnostic and Prognostic Roles of Fibrinogen Degradation Products and C-reactive Protein in Management of Sickle Cell Disease
Опубликована: Дек. 13, 2024
Introduction:
Abnormal
hemoglobin
is
a
hallmark
of
sickle
cell
disease
(SCD),
genetic
blood
abnormality
that
can
cause
number
clinical
consequences,
such
as
vaso-occlusive
crises
and
an
elevated
risk
infection.One
potential
biomarker
for
evaluating
activity
consequences
in
SCD
patients
C-reactive
protein
(CRP),
acute-phase
reactant
frequently
increased
inflammatory
conditions.Aim/Objectives:
The
purpose
this
study
to
assess
the
diagnostic
prognostic
value
FDP
CRP
levels
at
University
College
Hospital
Ibadan,
Nigeria.
Язык: Английский
Individuals afflicted with concurrent anemia, tuberculosis, and Candida albicans infection manifest: A pronounced state of immunosuppression
Open Journal of Clinical and Medical Case Reports,
Год журнала:
2023,
Номер
9(36)
Опубликована: Окт. 20, 2023
This
study
delved
into
the
immune
functionality
of
individuals
grappling
with
anemia,
tuberculosis,
and
Candida
albicans
infection.
The
findings
conclusively
revealed
that
this
cohort
manifested
a
pronounced
state
immunosuppression,
thereby
emphasizing
intricate
interplay
these
concurrent
maladies
on
landscape.
Subsequent
investigations
should
aim
to
unravel
underlying
mechanisms
orchestrating
immunosuppressive
milieu
contemplate
potential
interventions
aimed
at
alleviating
its
impact
response
dynamics.
Язык: Английский