Frontiers in Integrative Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Июль 12, 2024
The
SARS-CoV-2
pandemic
has
affected
771
million
people
and
caused
6.9
confirmed
deaths
as
of
November
2023.
Beyond
the
adversity,
a
crucial
less-explored
chapter
unfolds:
adaptive
sequelae.
These
have
altered
social,
mental,
emotional
conditions,
leaving
an
imprint
on
biological
systems.
While
some
cases
fully
resolve
pathological
process
post-acute
infection,
others
persist
with
symptoms,
posing
challenge
that
underscores
need
to
comprehend
pathophysiology
from
innovative
perspectives.
article
delves
into
“Long
COVID”
or
Post-Acute
COVID-19
Syndrome
(PACS),
where
symptoms
for
≥4
weeks
irrespective
initial
severity.
Risk
factors
include
history
severe
illness,
in-hospital
management,
intensive
care.
This
also
explores
theories,
derived
various
experimental
models,
demonstrated
involvement
nervous
system
in
coordination
psychoneuroimmunoendocrine
axes
expression
inflammation.
It
is
posited
PACS
involves
processes
peripheral
central
sensitization
(corticalization),
facilitating
dishomeostasis
chronicity
inflammatory
process.
In
this
context,
therapeutic
strategies
grounded
modulating
reflex
are
reviewed,
primarily
through
infiltration
local
anesthetics
via
linear
non-linear
approaches.
Neural
use
considered
stimulate
regulatory
circuits
coordinated
by
neuroimmune-endocrine
system.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Апрель 28, 2023
Micronutrients
have
been
associated
with
disease
severity
and
poorer
clinical
outcomes
in
patients
COVID-19.
However,
there
is
a
paucity
of
studies
examining
if
the
relationship
micronutrient
status
independent
recognised
prognostic
factors,
specifically
frailty
systemic
inflammatory
response
(SIR).
The
aim
present
study
was
to
examine
between
status,
frailty,
inflammation,
admitted
COVID-19.Retrospective
analysis
prospectively
collected
data
performed
on
confirmed
COVID-19,
hospital
1st
April
2020-6th
July
2020.
Clinicopathological
characteristics,
assessment,
biochemical
laboratory
results
were
recorded.
Frailty
determined
using
Clinical
scale.
SIR
serum
CRP.
interest
oxygen
requirement,
ITU
admission
30-day
mortality.
Categorical
variables
analysed
chi-square
test
binary
logistics
regression
analysis.
Continuous
Mann-Whitney
U
or
Kruskal
Wallis
tests.281
included.
55%
(n
=
155)
aged
≥
70
years
39%
109)
male.
49%
138)
frail
(CFS
>
3).
86%
242)
had
CRP
10
mg/L.
On
univariate
analysis,
significantly
thirty-day
mortality
(p
<
0.001).
found
be
an
requirement
non-frail
0.004).
Over
third
(36%)
low
vitamin
B1,
despite
having
normal
reference
range
values
red
cell
B2,
B6
selenium.
Furthermore,
lower
median
B1
0.029).Vitamin
stores
may
depleted
COVID-19
experiencing
significant
providing
rationale
for
thiamine
supplementation.
Further
longitudinal
are
warranted
delineate
trend
following
Microorganisms,
Год журнала:
2024,
Номер
12(5), С. 909 - 909
Опубликована: Апрель 30, 2024
Three
patients
with
relapsing
and
remitting
borreliosis,
babesiosis,
bartonellosis,
despite
extended
anti-infective
therapy,
were
prescribed
double-dose
dapsone
combination
therapy
(DDDCT)
for
8
weeks,
followed
by
one
or
several
two-week
courses
of
pulsed
high-dose
(HDDCT).
We
discuss
these
patients’
cases
to
illustrate
three
important
variables
required
long-term
remission.
First,
diagnosing
treating
active
co-infections,
including
Babesia
Bartonella
important.
rotations
multiple
anti-malarial
drug
combinations
herbal
therapies,
6-day
HDDCT
pulses
achieve
clinical
Second,
all
prior
oral,
intramuscular
(IM),
and/or
intravenous
(IV)
antibiotics
used
chronic
Lyme
disease
(CLD)/post-treatment
syndrome
(PTLDS),
irrespective
the
length
administration,
inferior
in
efficacy
short-term
biofilm/persister
i.e.,
dapsone,
rifampin,
methylene
blue,
pyrazinamide,
which
improved
resistant
fatigue,
pain,
headaches,
insomnia,
neuropsychiatric
symptoms.
Lastly,
addressing
factors
on
16-point
systemic
infectious
(MSIDS)
model
was
achieving
In
conclusion,
DDDCT
6–7-day
HDDCT,
while
abnormalities
MSIDS
map,
could
represent
a
novel
effective
strategy
CLD/PTLDS
associated
co-infections
Bartonella.
Frontiers in Integrative Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Июль 12, 2024
The
SARS-CoV-2
pandemic
has
affected
771
million
people
and
caused
6.9
confirmed
deaths
as
of
November
2023.
Beyond
the
adversity,
a
crucial
less-explored
chapter
unfolds:
adaptive
sequelae.
These
have
altered
social,
mental,
emotional
conditions,
leaving
an
imprint
on
biological
systems.
While
some
cases
fully
resolve
pathological
process
post-acute
infection,
others
persist
with
symptoms,
posing
challenge
that
underscores
need
to
comprehend
pathophysiology
from
innovative
perspectives.
article
delves
into
“Long
COVID”
or
Post-Acute
COVID-19
Syndrome
(PACS),
where
symptoms
for
≥4
weeks
irrespective
initial
severity.
Risk
factors
include
history
severe
illness,
in-hospital
management,
intensive
care.
This
also
explores
theories,
derived
various
experimental
models,
demonstrated
involvement
nervous
system
in
coordination
psychoneuroimmunoendocrine
axes
expression
inflammation.
It
is
posited
PACS
involves
processes
peripheral
central
sensitization
(corticalization),
facilitating
dishomeostasis
chronicity
inflammatory
process.
In
this
context,
therapeutic
strategies
grounded
modulating
reflex
are
reviewed,
primarily
through
infiltration
local
anesthetics
via
linear
non-linear
approaches.
Neural
use
considered
stimulate
regulatory
circuits
coordinated
by
neuroimmune-endocrine
system.
