Neurological symphony: post-acute COVID-19 syndrome, an innovative pathophysiological exploration from neuraltherapeutic medicine DOI Creative Commons
Carlos Bustamante, Laura Bibiana Pinilla Bonilla, Juan Carlos Restrepo

et al.

Frontiers in Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 12, 2024

The SARS-CoV-2 pandemic has affected 771 million people and caused 6.9 confirmed deaths as of November 2023. Beyond the adversity, a crucial less-explored chapter unfolds: adaptive sequelae. These have altered social, mental, emotional conditions, leaving an imprint on biological systems. While some cases fully resolve pathological process post-acute infection, others persist with symptoms, posing challenge that underscores need to comprehend pathophysiology from innovative perspectives. article delves into “Long COVID” or Post-Acute COVID-19 Syndrome (PACS), where symptoms for ≥4 weeks irrespective initial severity. Risk factors include history severe illness, in-hospital management, intensive care. This also explores theories, derived various experimental models, demonstrated involvement nervous system in coordination psychoneuroimmunoendocrine axes expression inflammation. It is posited PACS involves processes peripheral central sensitization (corticalization), facilitating dishomeostasis chronicity inflammatory process. In this context, therapeutic strategies grounded modulating reflex are reviewed, primarily through infiltration local anesthetics via linear non-linear approaches. Neural use considered stimulate regulatory circuits coordinated by neuroimmune-endocrine system.

Language: Английский

The relationship between micronutrient status, frailty, systemic inflammation, and clinical outcomes in patients admitted to hospital with COVID-19 DOI Creative Commons
Josh McGovern,

John Wadsworth,

Anthony Catchpole

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: April 28, 2023

Micronutrients have been associated with disease severity and poorer clinical outcomes in patients COVID-19. However, there is a paucity of studies examining if the relationship micronutrient status independent recognised prognostic factors, specifically frailty systemic inflammatory response (SIR). The aim present study was to examine between status, frailty, inflammation, admitted COVID-19.Retrospective analysis prospectively collected data performed on confirmed COVID-19, hospital 1st April 2020-6th July 2020. Clinicopathological characteristics, assessment, biochemical laboratory results were recorded. Frailty determined using Clinical scale. SIR serum CRP. interest oxygen requirement, ITU admission 30-day mortality. Categorical variables analysed chi-square test binary logistics regression analysis. Continuous Mann-Whitney U or Kruskal Wallis tests.281 included. 55% (n = 155) aged ≥ 70 years 39% 109) male. 49% 138) frail (CFS > 3). 86% 242) had CRP 10 mg/L. On univariate analysis, significantly thirty-day mortality (p < 0.001). found be an requirement non-frail 0.004). Over third (36%) low vitamin B1, despite having normal reference range values red cell B2, B6 selenium. Furthermore, lower median B1 0.029).Vitamin stores may depleted COVID-19 experiencing significant providing rationale for thiamine supplementation. Further longitudinal are warranted delineate trend following

Language: Английский

Citations

3
Evaluation of molecular mechanisms of riboflavin anti-COVID-19 action reveals anti-inflammatory efficacy rather than antiviral activity DOI
Roman Akasov,

Olga E. Chepikova,

Тatiana Pallaeva

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2024, Volume and Issue: 1868(5), P. 130582 - 130582

Published: Feb. 8, 2024

Language: Английский

Citations

0
Combining Double-Dose and High-Dose Pulsed Dapsone Combination Therapy for Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome and Co-Infections, Including Bartonella: A Report of 3 Cases and a Literature Review DOI Creative Commons
Richard I. Horowitz,

John F. Fallon,

Phyllis R. Freeman

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 909 - 909

Published: April 30, 2024

Three patients with relapsing and remitting borreliosis, babesiosis, bartonellosis, despite extended anti-infective therapy, were prescribed double-dose dapsone combination therapy (DDDCT) for 8 weeks, followed by one or several two-week courses of pulsed high-dose (HDDCT). We discuss these patients’ cases to illustrate three important variables required long-term remission. First, diagnosing treating active co-infections, including Babesia Bartonella important. rotations multiple anti-malarial drug combinations herbal therapies, 6-day HDDCT pulses achieve clinical Second, all prior oral, intramuscular (IM), and/or intravenous (IV) antibiotics used chronic Lyme disease (CLD)/post-treatment syndrome (PTLDS), irrespective the length administration, inferior in efficacy short-term biofilm/persister i.e., dapsone, rifampin, methylene blue, pyrazinamide, which improved resistant fatigue, pain, headaches, insomnia, neuropsychiatric symptoms. Lastly, addressing factors on 16-point systemic infectious (MSIDS) model was achieving In conclusion, DDDCT 6–7-day HDDCT, while abnormalities MSIDS map, could represent a novel effective strategy CLD/PTLDS associated co-infections Bartonella.

Language: Английский

Citations

0
Neurological symphony: post-acute COVID-19 syndrome, an innovative pathophysiological exploration from neuraltherapeutic medicine DOI Creative Commons
Carlos Bustamante, Laura Bibiana Pinilla Bonilla, Juan Carlos Restrepo

et al.

Frontiers in Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 12, 2024

The SARS-CoV-2 pandemic has affected 771 million people and caused 6.9 confirmed deaths as of November 2023. Beyond the adversity, a crucial less-explored chapter unfolds: adaptive sequelae. These have altered social, mental, emotional conditions, leaving an imprint on biological systems. While some cases fully resolve pathological process post-acute infection, others persist with symptoms, posing challenge that underscores need to comprehend pathophysiology from innovative perspectives. article delves into “Long COVID” or Post-Acute COVID-19 Syndrome (PACS), where symptoms for ≥4 weeks irrespective initial severity. Risk factors include history severe illness, in-hospital management, intensive care. This also explores theories, derived various experimental models, demonstrated involvement nervous system in coordination psychoneuroimmunoendocrine axes expression inflammation. It is posited PACS involves processes peripheral central sensitization (corticalization), facilitating dishomeostasis chronicity inflammatory process. In this context, therapeutic strategies grounded modulating reflex are reviewed, primarily through infiltration local anesthetics via linear non-linear approaches. Neural use considered stimulate regulatory circuits coordinated by neuroimmune-endocrine system.

Language: Английский

Citations

0