Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 13, 2024

The strong ethnopharmacological utilization of Isodon rugosus Wall. Ex. Benth is evident in the treatment several types pain and inflammation, including toothache, earache, abdominal pain, gastric generalized body inflammation. Based on this background, antinociceptive effects crude extract, various fractions, essential oil have been reported previously. In research work, we isolate characterize pure bioactive compounds from I. evaluate possible mechanisms using vivo vitro models. were analyzed for analgesic anti-inflammatory activities through assays. column chromatography chloroform fraction led to identification two compounds, i.e., 1 2. Compound demonstrated notable inhibition (62% writhing inhibition, 72.77% COX-2 76.97% 5-LOX inhibition) potential (>50% paw edema at intervals). mechanism involved antinociception was considered primarily, a concept that has already elucidated application naloxone (an antagonist opioid receptors). involvement adrenergic receptors investigated hot plate model receptor antagonist). ethnomedicinal background , supported by previous reports current observations, leads conclusion source compounds. It may be concluded results isolated alternative remedy inflammation management with admirable efficacy safety profiles.

Язык: Английский

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Isolation, invitro, invivo anti-inflammatory, analgesic and antioxidant potential of Habenaria plantegania Lindl

Inflammopharmacology, Год журнала: 2024, Номер 32(2), С. 1353 - 1369

Опубликована: Фев. 9, 2024

Язык: Английский

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Measurement, Solvent Effect, and Thermodynamic Modeling of the Solubility of Benzohydrazide and 2-Hydroxybenzohydrazide in Six Pure Solvents

Journal of Chemical & Engineering Data, Год журнала: 2024, Номер 69(9), С. 3148 - 3156

Опубликована: Авг. 16, 2024

Benzohydrazide (BH) and 2-hydroxybenzohydrazide (HBH) have gained attention due to their diverse characteristics wide applications in pharmacy organic synthesis. In this study, a gravimetric technique was used measure the ability of BH HBH dissolve six monosolvents [water, methanol (MeOH), ethanol (EtOH), propan-1-ol (1-PrOH), propan-2-ol (2-PrOH), butan-1-ol (1-BuOH)] at an atmospheric pressure 0.1 MPa. The solubility measured temperature range 288.15–328.15 5 K intervals. It is revealed that based on temperature, rises with increase temperature. dissolves from high low following order: water < 1-BuOH 2-PrOH 1-PrOH EtOH MeOH, while for HBH, it > MeOH 1-BuOH. solvent effects, which account connections between solute, were studied using linear solvation energy relationship. solubilities successfully correlated modified Apelblat equation, van't Hoff NRTL, Wilson models, λh equation. values calculated these models aligned experimental solubility. highest relative average deviation root-mean-square 21.30 × 10–4 4.04% (λh equation) 11.62 6.09% (NRTL model), respectively. Also, model data utilized evaluate mixing thermodynamic properties BH, including excess Gibbs free enthalpy.

Язык: Английский

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Evaluation of Antipyretic and Antioxidant Activities of Ten Indigenous Medicinal Plants of Tirtajaya, Karawang Regency, West Java, Indonesia

Indian Journal of Pharmaceutical Education and Research, Год журнала: 2025, Номер 59(1), С. 252 - 263

Опубликована: Янв. 6, 2025

Aim This research aimed to explore the antipyretic and antioxidant activity of infusions Chromolaena odorata (COI), Abelmoschus manihot (AMI), Annona muricata (AMCI), Allium ascalonicum (AAI), Carica papaya (CPI), Tamarindus indica (TII), Zingiber officinale (ZOI ), Abrus precatorius (API), Momordica charantia (MCI) Strobilanthes crispus (SCI). Materials Methods The plant was tested using a peptone-induced rat model. male used were divided into 32 groups for each test. Each group consisted four rats, including negative control, positive control (paracetamol 150 mg/kg) COI, AMI, AMCI, AAI, CPI, TII, ZOI, API, MCI SCI, administered doses 100, 200 400 mg/kg. Initial rectal temperature recorded thermometer at depth 1.5 cm in rectum. Fever induction confirmed by rise more than 0.5°C. After drug administration, periodically 1, 2, 3 4 hr. Furthermore, DPPH method. Results results showed that administration SCI able significantly reduce febrile which depended on dose time. test indicated AAI exhibited very strong intensity, while API COI had medium AMI weak intensity TII displayed intensity. Conclusion Based results, it can be concluded exhibit activity.

Язык: Английский

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Solvability Measurement, Solvent Impact, Thermodynamic Modeling, and Special Solvation of Benzohydrazide in Aqueous Cosolvent Combinations of Some Alcohols

Journal of Chemical & Engineering Data, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

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Synthesis and pharmacological evaluation of heteroarylamide derivatives as potential analgesic, anti-inflammatory, antidiarrheal and cytotoxic agents

Heliyon, Год журнала: 2024, Номер 10(23), С. e40630 - e40630

Опубликована: Ноя. 22, 2024

Язык: Английский

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