Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158615 - 158615
Опубликована: Дек. 1, 2024
Язык: Английский
Intelligent Pharmacy, Год журнала: 2024, Номер 2(3), С. 367 - 380
Опубликована: Фев. 24, 2024
To create novel treatments and treat complex diseases, the pharmaceutical sector is essential. Drug discovery, however, a time-consuming, pricey, dangerous endeavor. Artificial intelligence (AI) has become potent instrument that transformed several industries, including healthcare, in recent years. This summary gives general overview of how AI expediting creation medicines, revolutionizing sector, enabling drug discovery. The experiencing discovery revolution because AI. process changing at different phases approaches like machine learning deep learning. abstract demonstrates facilitates development through target identification, lead compound optimization, design, repurposing, clinical trial enhancement. integration potential to hasten treatments, save costs, improve patient outcomes. fully realize research development, issues relating data accessibility, algorithm interpretability, laws must be resolved.
Язык: Английский
Процитировано
28
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117058 - 117058
Опубликована: Июль 4, 2024
The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process, contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation. In contrast modern synthetic therapies, naturally occurring phytoconstituents are well-studied inhibitors of that now attracting increased attention context because lower toxicity, better safety efficacy, cost-effectiveness. This study explores recent research on phytoconstituent-based therapies delve into their action mechanisms targeting potential for assisting effective wounds. For this purpose, we have carried out surveys literature analyzed studies from prominent databases such as Science Direct, Scopus, PubMed, Google Scholar, EMBASE, Web Science. classification various categorie as: alkaloids, triterpenoids, phenolics, polyphenols, flavonoids, monoterpene glycosides, naphthoquinones tocopherols. Noteworthy phytoconstituents, including Neferine, Plumbagin, Boswellic acid, Genistein, Luteolin, Kirenol, Rutin, Vicenin-2, Gamma-tocopherol, Icariin, Resveratrol, Mangiferin, Betulinic Berberine, Syringic Gallocatechin, Curcumin, Loureirin-A, Loureirin-B, Lupeol, Paeoniflorin, Puerarin emerge these promising agents through inhibition pathway. Extensive has revealed how they modulate signalling pathways, NF-κB, demonstrate development therapeutic assist chronic
Язык: Английский
Процитировано
21
Cell Death and Disease, Год журнала: 2024, Номер 15(4)
Опубликована: Апрель 17, 2024
Abstract Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place heavy financial strain on both patients the healthcare establishment. The lack effective treatments contributes to this pessimistic situation negative outlook. Exosomes released from mesenchymal stromal cells (MSCs) have emerged as most likely new breakthrough advancement in treating diabetes diabetes‐associated complication due capacity intercellular communication, modulating local microenvironment, regulating cellular processes. In present review, we briefly outlined properties MSCs-derived exosomes, provided thorough summary their biological functions potential uses related complications.
Язык: Английский
Процитировано
19
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Авг. 29, 2024
Abstract The challenge in treating diabetic foot infections caused by drug‐resistant bacteria is rapidly eradicating and accelerating wound healing. NIR‐II‐induced photothermal therapy (PTT) offers notable advantages over conventional treatments, such as broad‐spectrum bactericidal efficacy, better penetration depth biological tissues, higher skin tolerance thresholds, making it particularly suitable for addressing infections. Herein, found that NIR‐II dye IR26 exhibited good effects but poor stability. By modifying with methoxy triphenylamine groups, a novel D–A–D‐type small molecule agent (IRC) developed, high stability conversion efficiency (44.3%). IRC maximum absorption wavelength of 1166 nm emission 1238 nm. However, PTT alone cannot effectively promote Therefore, nanoplatforms (Cur‐IRC@PCM) are developed coloading curcumin, natural wound–healing compound, into thermosensitive liposomes to treat MRSA‐infected wounds. Under 980 laser irradiation, Cur‐IRC@PCM provided controlled the precise release synergizing eradicate accelerate closure. intelligent antibacterial also exhibits excellent biocompatibility, rendering promising therapeutic tool biomedical fields combating bacterial
Язык: Английский
Процитировано
13
Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 153370 - 153370
Опубликована: Июнь 20, 2024
Язык: Английский
Процитировано
10
Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 6, 2024
Abstract Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. complex conditions complicate effective wound management, prompting development of advanced diabetic care strategies that exploit specific characteristics such as acidic pH, high glucose stress trigger controlled drug release, thereby enhancing therapeutic effects dressings. Among solutions, hydrogels emerge promising due their stimuli‐responsive nature, making them highly for managing these The latest advancements in mono/multi‐stimuli‐responsive smart showcase superiority potential healthcare materials, highlighted relevant case studies. However, traditional dressings fall short meeting nuanced needs wounds, adjustable adhesion, easy removal, real‐time status monitoring, dynamic release adjustment according wound's conditions. Responsive represent a significant leap forward proficient sensing responding environment, offering more targeted approach treatment. This review highlights recent dressing, delivery, emphasizing role improving healing. It addresses ongoing challenges future directions, aiming guide clinical adoption.
Язык: Английский
Процитировано
9
Nutrients, Год журнала: 2025, Номер 17(2), С. 266 - 266
Опубликована: Янв. 13, 2025
Background: This study investigated the wound-healing potential of hispolon, a polyphenolic pigment derived from medicinal mushrooms, under diabetic conditions using both in vitro and vivo models. Methods: In assays, L929 fibroblast cells exposed to high glucose (33 mmol/L) were treated with hispolon at concentrations 2.5, 5, 7.5, or 10 μmol/L. streptozotocin-induced rats excision wounds received daily topical applications 0.2 g 5% (w/w) ointment. Results: Hispolon improved cell viability; suppressed oxidative stress by reducing reactive oxygen species, lipid peroxidation, DNA damage; restored reduced glutathione/oxidized glutathione ratio. The scratch assay demonstrated that μmol/L enhanced migration impaired high-glucose conditions. Treatment ointment accelerated wound contraction, epithelialization time, tissue regeneration an efficacy comparable Fespixon® cream, as shown histological findings increased activity, collagen deposition, capillary growth. also modulated macrophage polarization M1 markers enhancing M2 markers. rat dead-space-wound model, levels pro-inflammatory cytokines, those anti-inflammatory cytokines growth factors, stimulated Type I III synthesis, effectively promoting healing. incisional wounds, wound-breaking strength, showing results cream. Safety assessments confirmed showed no acute dermal toxicity. These underscore hispolon’s promising candidate for management mitigating stress, regeneration, accelerating
Язык: Английский
Процитировано
1
Biochemical Pharmacology, Год журнала: 2024, Номер 226, С. 116399 - 116399
Опубликована: Июнь 27, 2024
Язык: Английский
Процитировано
7
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Дек. 5, 2024
Abstract Neutrophils, the most abundant type of granulocyte, are widely recognized as one pivotal contributors to acute inflammatory response. Initially, neutrophils were considered mobile infantry innate immune system, tasked with immediate response invading pathogens. However, recent studies have demonstrated that versatile cells, capable regulating various biological processes and impacting both human health disease. Cytokines other active mediators regulate functional activity by activating multiple receptors on these thereby initiating downstream signal transduction pathways. Dysfunctions in disruptions neutrophil homeostasis been implicated pathogenesis numerous diseases, including cancer disorders, often due aberrant intracellular signaling. This review provides a comprehensive synthesis functions, integrating advancements this field. Moreover, it examines roles signaling pathways involved regulation activity. The pathophysiology diseases emerging therapeutic approaches targeting them also elaborated. addresses current limitations within field research, highlighting critical gaps knowledge warrant further investigation. In summary, seeks establish multidimensional model regulation, providing new perspectives for potential clinical applications research.
Язык: Английский
Процитировано
6
Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 10, С. 100401 - 100401
Опубликована: Фев. 22, 2024
Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a common flavonoid in many fruits, vegetables, and medicinal herbs. Plants rich luteolin have been used Chinese traditional medicine for treating various diseases, such as hypertension, inflammatory disorders, cancer. Throughout history, herbal medicines employed to address range of health issues their associated complications. This review delves into the biological characteristics, pharmacological importance, clinical analytical aspects potential use. study explores properties relevance luteolin, drawing support from both applications scientific findings. The information on has curated reputable sources Science Direct, PubMed, Google Scholar, Google, Scopus. Additionally, this paper incorporates data books, journals, reports provide well-rounded understanding luteolin's properties. Scientific investigations underscored significance diverse luteolin. Research revealed efficacy exhibiting anti-inflammatory, antioxidant, anti-cancer, wound healing, antimicrobial, antiviral, COVID-19 related Furthermore, its effectiveness extends anti-aging, antiallergic, cardioprotective, arthritis, neuroprotective, periodontal disorder, renal hepatoprotective, eye obesity, cytotoxicity, genotoxicity. compounds versatility therapeutic agent accentuated by adept interaction with molecular targets, influencing crucial cellular pathways. article provides pertaining identification isolation samples, underscoring across spectrum health-related domains. present highlights importance showcasing applicability addressing human diseases mitigating side effects. ADAM, A disintegrin Metalloproteinase; AMPK, Adenosine monophosphate, Activated protein kinase; AOM, azoxymethane; AP, activator protein; ApoE, apolipoprotein E-deficient; AR, Androgen receptor; ASD, Autistic disorders; CCl4, Tetrachloromethane; ccRCC, Clear cell carcinoma; CIA, Collagen-induced arthritis; CK-MB, Creatine kinase-MB; COVID-19,Coronavirus disease 2019; COX-2, Cyclooxygenase-2; DEDD2, Death effector domain-containing 2; EGFR, Epidermal growth factor FZD6, Frizzled class receptor6; FZJDXJ, Fuzheng Jiedu Xiaoji formulation; GBM, Glioblastoma multiforme grade IV; H. pylori, Helicobacter pylori; HBV, Hepatitis B virus; HCC, Hepatocellular HGI, Hypertrophic factor; HIV, Human immunodeficiency HNF4α, Hepatocyte nuclear 4α; IgE, Immunoglobulin E; IL, Interleukin; iNOS, Inducible nitric oxide synthase; IRAK1, Inhibiting interleukin-1 receptor-associated JNK, Jun N terminal K. Ras, Kirsten rat sarcoma L7Gn, Luteolin-7-O-glucuronide; LDH, Lactate dehydrogenase; LIP, Labile iron pool; LPS, Lipopolysaccharide; LTL, Luteolin; MAPK, Mitogen-activated MDA, Malondialdehyde; MICs, Minimum inhibitory concentrations; MMP-1, Matrix metalloproteinase 1; MPTP, Mitochondrial permeability transition pores; MRSA, Methicillin-resistant staphylococcus aureus; MSH, Melanocyte-stimulating hormone; MTP, transmembrane potential; NAFLD, Non-alcoholic fatty liver disease; NF, NF-κB, Nuclear factor-kappa B; Nlrp3, NOD-like receptor family pyrin domain containing 3; NO, Nitric oxide; NRCMs, Neonatal cardiomyocytes; Nrf2, erythroid NSCLC, Non-small lung cancer; PARP, poly-ADP ribose polymerase; PC, Prostate PDEF, Prostate-derived Ets PEA, Palmitoylethanolamide; PFS, Progression-free survival; POD, Post-operative delirium; PSA, Prostate-specific antigen levels; qPCR, Quantitative Polymerase chain reaction; ROS, Reactive oxygen species; Rpt, Proteasome-regulated particles; RTPCR, Real-time reverse transcriptase-polymerase SARS-CoV-2, Severe acute respiratory syndrome coronavirus SOD, Superoxide dismutase; SREBP, Sterol regulatory element binding sT antigen, Soluble tumor antigen; STAT, Signal transducer transcription; Syk, Spleen Tyrosine Kinase; TACE, Transcatheter arterial chemoembolization; TCM, Traditional chinese medicines; TNF-α, Tumor necrosis factor-α; TRAIL, TNF apoptosis-inducing ligand; TXNIP, Thioredoxin interacting protein.
Язык: Английский
Процитировано
5