Redox control of NRF2 signaling in oocytes harnessing Porphyra derivatives as a toggle DOI
E. Kim,

Dabin Cha,

Sung Joo Jang

и другие.

Free Radical Biology and Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

Research progress on Nrf2 intervention in the treatment of diabetic retinopathy DOI Creative Commons
Yuchen Yang, Haidong Zou

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Май 21, 2025

Diabetic retinopathy (DR) is a primary cause of vision loss among individuals with diabetes and represents the most prevalent microvascular complication mellitus. Its pathophysiological mechanisms involve processes such as oxidative stress, chronic inflammation, cell apoptosis, angiogenesis. As core transcription factor in antioxidant response, Nrf2 upregulates expression genes through Keap1-Nrf2-ARE pathway, hence reducing reactive oxygen species (ROS) levels retinal cells alleviating stress correlated damage. By activating Nrf2, release pro-inflammatory cytokines inhibited, which helps mitigate inflammation delays DR progression anti-apoptotic effects, suppression angiogenesis ferroptosis inhibition. This review highlights Nrf2-related regulatory latest research progress regarding its function DR, offering theoretical foundation for Nrf2-targeted therapies.

Язык: Английский

Процитировано

0
Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis DOI Creative Commons
Hang Han, Guojiang Zhang, Yuanyuan Yang

и другие.

Redox Biology, Год журнала: 2024, Номер 79, С. 103482 - 103482

Опубликована: Дек. 25, 2024

Psoriasis is a chronic inflammatory skin condition characterized by erythematous plaques with white scales. Its pathogenesis closely linked to oxidative stress and an imbalance in Th1/Th2 immune responses. Current treatments for psoriasis, such as topical agents, systemic therapies phototherapy, frequently fail achieve complete remission clinical settings. Monomethyl fumarate (MMF), which has been approved the US Food Drug Administration 2020 multiple sclerosis, demonstrated efficacy psoriasis management. Additionally, our previous studies have identified aluminum ions beneficial treatment. This present study investigates combined therapeutic effects of MMF observed that combination treatment achieves superior compared either alone mouse model through modulation Nrf2/NF-κB signaling pathway, cellular models. The first activates Nrf2 nuclear translocation induces antioxidant gene expression, followed inhibition NF-κB phosphorylation, reduces Th1 cytokine production chemotaxis. Concurrently, elevates Th2 secretion, thereby increasing anti-inflammatory response HaCaT cells. Overall, these findings support (MMFAL) potential strategy effectively diminishing inflammation stress.

Язык: Английский

Процитировано

2
Efficacy of N-Acetylcysteine as an Adjuvant Therapy for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials DOI
Tingting He,

Kehui Ren,

Xiang Li

и другие.

British Journal of Hospital Medicine, Год журнала: 2024, Номер 85(11), С. 1 - 16

Опубликована: Ноя. 18, 2024

Aims/Background Rheumatoid arthritis (RA) is an inflammatory autoimmune disease and N-acetylcysteine (NAC) considered a potential therapeutic agent for RA due to strong antioxidant anti-inflammatory properties. Therefore, this systematic review meta-analysis aimed evaluate the efficacy of NAC as adjuvant therapy RA. Methods A search was conducted across five databases from inception 1 August 2024, including CINAHL, Cochrane Library, EMBASE, PubMed, Web Science. The risk-of-bias tool randomized trials used assess quality included studies. Sensitivity analysis performed when significant heterogeneity identified. Results Four studies involving 204 patients were in our meta-analysis. results indicated that alleviated activity (Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR): mean difference (MD) = 0.54). Additionally, reduced markers (erythrocyte (ESR): MD 3.00). However, beneficial effects on oxidative stress not observed. Conclusion This demonstrated reducing markers, improving joint tenderness, swelling with

Язык: Английский

Процитировано

1
Maresin1 Inhibits Ferroptosis via the Nrf2/SLC7A11/GPX4 Pathway to Protect Against Sepsis-Induced Acute Liver Injury DOI Creative Commons

Yongjing Guo,

Huimin Chen, Jian Sun

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 11041 - 11053

Опубликована: Дек. 1, 2024

Maresin 1 (MaR1) is a specialized pro-resolving mediator with anti-inflammatory properties that promotes tissue repair. This study aims to investigate the molecular involvement of MaR1 in protecting against sepsis-induced acute liver injury (SI-ALI).

Язык: Английский

Процитировано

1
Methylophiopogonanone A Inhibits Ferroptosis in H9c2 Cells: An Experimental and Molecular Simulation Study DOI Creative Commons
Yanqing Wang,

Xi Zhao,

Ban Chen

и другие.

Molecules, Год журнала: 2024, Номер 29(23), С. 5764 - 5764

Опубликована: Дек. 6, 2024

In this study, homoisoflavone methylophiopogonanone A (MOA) was investigated for its inhibitory effect on ferroptosis of H9c2 cells using a set cellular assays, such as BODIPY-probed and H

Язык: Английский

Процитировано

0
Redox control of NRF2 signaling in oocytes harnessing Porphyra derivatives as a toggle DOI
E. Kim,

Dabin Cha,

Sung Joo Jang

и другие.

Free Radical Biology and Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0