Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances
Gels,
Год журнала:
2025,
Номер
11(2), С. 88 - 88
Опубликована: Янв. 23, 2025
There
is
ongoing
research
for
biomedical
applications
of
polyvinyl
alcohol
(PVA)-based
hydrogels;
however,
the
execution
this
has
not
yet
been
achieved
at
an
appropriate
level
commercialization.
Advanced
perception
necessary
design
and
synthesis
suitable
materials,
such
as
PVA-based
hydrogel
applications.
Among
polymers,
drawn
great
interest
in
owing
to
their
attractive
potential
with
characteristics
good
biocompatibility,
mechanical
strength,
apposite
water
content.
By
designing
approach
investigating
structure,
hydrogels
can
attain
superb
cytocompatibility,
flexibility,
antimicrobial
activities,
signifying
that
it
a
candidate
tissue
engineering
regenerative
medicine,
drug
delivery,
wound
dressing,
contact
lenses,
other
fields.
In
review,
we
highlight
current
progresses
on
explaining
diverse
usage
across
variety
areas.
We
explain
numerous
techniques
related
phenomena
based
these
materials.
This
review
may
stipulate
wide
reference
future
acumens
materials
extensive
Язык: Английский
Crosslinked Biodegradable Hybrid Hydrogels Based on Poly(ethylene glycol) and Gelatin for Drug Controlled Release
Molecules,
Год журнала:
2024,
Номер
29(20), С. 4952 - 4952
Опубликована: Окт. 19, 2024
A
series
of
hybrid
hydrogels
poly(ethylene
glycol)
(PEG)
were
synthesized
using
gelatin
as
a
crosslinker
and
investigated
for
controlled
delivery
the
first-generation
cephalosporin
antibiotic,
Cefazedone
sodium
(CFD).
commercially
available
4-arm-PEG-OH
was
first
modified
to
obtain
four-arm-PEG-succinimidyl
glutarate
(4-arm-PEG-SG),
which
formed
gelatin-PEG
composite
(S
Язык: Английский
A 3D Bioprinted Gelatine‐Based Bilayer Hydrogel Dressing Loaded With Curcumin and Ciprofloxacin Hydrochloride With Antibacterial, Anti‐Inflammatory and Antioxidative Properties
Biotechnology Journal,
Год журнала:
2025,
Номер
20(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Skin
wound
repair,
a
highly
integrated
and
overlapping
complex
process,
is
susceptible
to
infection,
excessive
inflammation,
high
oxidative
stress,
which
can
prolong
the
healing
time
or
even
lead
chronic
wound.
Meanwhile,
single‐layer
hydrogels
are
unavoidably
dehydrated
usually
due
water
evaporation,
not
conducive
healing.
Therefore,
bilayer
hydrogel
dressing
composed
of
gelatin
(G)
sodium
alginate
(A)
loaded
with
ciprofloxacin
(C)
curcumin
(Cur)
was
manufactured
by
extrusion
3D
bioprinting
technology
in
this
study,
denoted
as
GACCur.
The
experimental
results
showed
that
50
µg/mL
Cur
(GACCur50)
had
excellent
antibacterial
properties
antioxidative
activity
54.35
±
0.48%
DPPH
scavenging
ratio.
In
addition,
GACCur50
exhibited
capacity
mitigate
polarization
inflammatory
cells
toward
pro‐inflammatory
states,
observably
reducing
expression
pertinent
cytokines.
Furthermore,
also
good
biocompatibility
assessed
live‐dead
fluorescent
staining,
scanning
electron
microscopy
(SEM),
CCK‐8
test.
promising
for
Язык: Английский
Bioinspired Suction-Driven Strategies with Nanoscale Skin-Controllable Adhesive Architectures for Efficient Liquid Formulated Transdermal Patches
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
For
highly
efficient
and
precise
drug
release,
transdermal
delivery
systems
(TDDS)
have
recently
evolved
through
the
combination
of
intelligent
material-based
structures
with
various
active
components.
These
strategies
are
an
effort
to
overcome
significant
difficulties
in
delivering
large
molecule
drugs
nanomaterials
due
physical
barrier
skin,
especially
stratum
corneum,
traditional
TDDS.
Interestingly,
multiscale
suction-driven
architectures
(SDAs)
inspired
by
bioinspired
suction
adhesion
mechanisms
provided
innovative
solutions
these
challenges.
employ
negative
pressure
enhance
nanoscale
skin-controllable
skin
adhesion,
temporarily
bypass
barrier,
facilitate
deep
penetration
therapeutic
agents,
thereby,
achieving
goals
increasing
efficiency
maximizing
user
convenience
as
a
minimal
invasive,
needle-free
platform.
This
review
provides
comprehensive
overview
patches
emphasizes
their
integration
multifunctional
materials
achieve
stable
controlled
release.
Next,
we
present
cost-effective
user-friendly
patch
devices
optimization
cupping
without
incorporation
additional
devices.
Furthermore,
that
optimize
need
for
Potential
SDAs
localized
systemic
challenging
complex
well
future
perspectives,
discussed,
along
directions
more
patient-centric
solutions.
Язык: Английский
Self‐Coacervation of Oligo(ethylene glycol) and Oligo(2‐ethyl‐2‐oxazoline)‐Based Double Hydrophilic Brush Block Copolymers in Aqueous Solution
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
Abstract
Coacervates
are
a
highly
relevant
class
of
structures
formed
via
liquid–liquid
phase
separation
and
new
coacervate‐forming
polymers
sought
after.
Here,
the
formation
simple
coacervate
droplets
from
double
hydrophilic
block
copolymer
(DHBC)
with
combination
poly(oligo
ethylene
glycol
methacrylate)
(POEGMA)
2‐ethyl‐2‐oxazoline
(POEtOx)
without
use
external
triggers
or
charges
is
shown.
At
high
concentration
25
wt.%,
DHBC
forms
sizes
in
low
micrometre
range.
The
have
relatively
stability
over
long
period
time
only
minor
coalescence
observed
after
4
weeks.
concentrations,
no
coacervation
observed.
Furthermore,
copolymers
monomers
also
do
not
show
clearly
indicating
that
architecture
required
to
form
desired
structures.
addition
guest
biomacromolecules
at
concentrations
shows
specific
partitioning
behaviour
preference
for
polymer
aqueous
phase.
enrichment
observed,
line
common
water‐in‐water
(w/w)
emulsions.
These
findings
constitute
direction
systems
interest
biotechnology,
synthetic
cell
environment
mimics
drug
delivery.
Язык: Английский
Highly thermoelectric ionic hydrogel similar to fever cooling patch applied to lithium-ion battery cooling and intelligent overheating warning
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 162924 - 162924
Опубликована: Апрель 1, 2025
Язык: Английский
Stochastic stability and global dynamics of a mathematical model for drug use: Statistical sensitivity analysis via PRCC
Partial Differential Equations in Applied Mathematics,
Год журнала:
2024,
Номер
unknown, С. 100964 - 100964
Опубликована: Окт. 1, 2024
Язык: Английский
Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing
Pharmaceutics,
Год журнала:
2024,
Номер
17(1), С. 4 - 4
Опубликована: Дек. 24, 2024
Background:
Skin
ageing,
driven
predominantly
by
oxidative
stress
from
reactive
oxygen
species
(ROS)
induced
environmental
factors
like
ultraviolet
A
(UVA)
radiation,
accounts
for
approximately
80%
of
extrinsic
skin
damage.
L-glutathione
(GSH),
a
potent
antioxidant,
holds
promise
in
combating
UVA-induced
stress.
However,
its
instability
and
limited
penetration
through
the
stratum
corneum
hinder
topical
application.
This
study
introduces
novel
solid
lipid
nanoparticle
(SLN)-enriched
hydrogel
designed
to
enhance
GSH
stability,
penetration,
sustained
release
anti-ageing
applications.
Methods:
GSH-loaded
SLNs
were
prepared
via
double-emulsion
technique
optimized
using
factorial
design.
These
incorporated
into
1-3%
(w/v)
Carbopol
hydrogels
produce
semi-solid
formulation.
The
hydrogel's
characteristics,
including
morphology,
mechanical
rheological
properties,
drug
release,
antioxidant
activity,
cytotoxicity,
evaluated.
Results:
SEM
FTIR
confirmed
uniform
dispersion
within
hydrogel.
formulation
exhibited
desirable
gel
strength
(5.1
±
0.5
g),
spreadability
(33.6
1.9
g·s),
pseudoplasticity,
elasticity.
In
vitro
studies
revealed
biphasic
profile,
with
over
72
h
70%
cumulative
release.
significantly
improved
capacity,
protecting
human
fibroblasts
enhancing
cell
viability.
Stability
indicated
that
4
°C
was
optimal
storage
three
months.
Notably,
enhanced
3.7-fold.
Conclusions:
SLN-enriched
effectively
improves
delivery
efficacy,
providing
promising
platform
other
bioactive
compounds
similar
challenges.
Язык: Английский
Exosome-Integrated Hydrogels for Bone Tissue Engineering
Gels,
Год журнала:
2024,
Номер
10(12), С. 762 - 762
Опубликована: Ноя. 23, 2024
Exosome-integrated
hydrogels
represent
a
promising
frontier
in
bone
tissue
engineering,
leveraging
the
unique
biological
properties
of
exosomes
to
enhance
regenerative
capabilities
hydrogels.
Exosomes,
as
naturally
occurring
extracellular
vesicles,
carry
diverse
array
bioactive
molecules
that
play
critical
roles
intercellular
communication
and
regeneration.
When
combined
with
hydrogels,
these
can
be
spatiotemporally
delivered
target
sites,
offering
controlled
sustained
release
therapeutic
agents.
This
review
aims
provide
comprehensive
overview
recent
advancements
development,
application
exosome-integrated
for
highlighting
their
potential
overcome
current
challenges
Furthermore,
explores
mechanistic
pathways
by
which
embedded
within
facilitate
repair,
encompassing
regulation
inflammatory
pathways,
enhancement
angiogenic
processes,
induction
osteogenic
differentiation.
Finally,
addresses
existing
challenges,
such
scalability,
reproducibility,
regulatory
considerations,
while
also
suggesting
future
directions
research
this
rapidly
evolving
field.
Thus,
we
hope
contributes
advancing
development
next-generation
biomaterials
synergistically
integrate
exosome
hydrogel
technologies,
thereby
enhancing
efficacy
Язык: Английский