Exosome-Integrated Hydrogels for Bone Tissue Engineering DOI Creative Commons

Hee Sook Hwang,

Chung‐Sung Lee

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 762 - 762

Published: Nov. 23, 2024

Exosome-integrated hydrogels represent a promising frontier in bone tissue engineering, leveraging the unique biological properties of exosomes to enhance regenerative capabilities hydrogels. Exosomes, as naturally occurring extracellular vesicles, carry diverse array bioactive molecules that play critical roles intercellular communication and regeneration. When combined with hydrogels, these can be spatiotemporally delivered target sites, offering controlled sustained release therapeutic agents. This review aims provide comprehensive overview recent advancements development, application exosome-integrated for highlighting their potential overcome current challenges Furthermore, explores mechanistic pathways by which embedded within facilitate repair, encompassing regulation inflammatory pathways, enhancement angiogenic processes, induction osteogenic differentiation. Finally, addresses existing challenges, such scalability, reproducibility, regulatory considerations, while also suggesting future directions research this rapidly evolving field. Thus, we hope contributes advancing development next-generation biomaterials synergistically integrate exosome hydrogel technologies, thereby enhancing efficacy

Language: Английский

Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances DOI Creative Commons
Mohammad Mizanur Rahman Khan, Md. Mahamudul Hasan Rumon

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 88 - 88

Published: Jan. 23, 2025

There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive

Language: Английский

Citations

3
Crosslinked Biodegradable Hybrid Hydrogels Based on Poly(ethylene glycol) and Gelatin for Drug Controlled Release DOI Creative Commons
Zhenzhen Zhao, Zihao Qin,

Tianqing Zhao

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(20), P. 4952 - 4952

Published: Oct. 19, 2024

A series of hybrid hydrogels poly(ethylene glycol) (PEG) were synthesized using gelatin as a crosslinker and investigated for controlled delivery the first-generation cephalosporin antibiotic, Cefazedone sodium (CFD). commercially available 4-arm-PEG-OH was first modified to obtain four-arm-PEG-succinimidyl glutarate (4-arm-PEG-SG), which formed gelatin-PEG composite (S

Language: Английский

Citations

5
A 3D Bioprinted Gelatine‐Based Bilayer Hydrogel Dressing Loaded With Curcumin and Ciprofloxacin Hydrochloride With Antibacterial, Anti‐Inflammatory and Antioxidative Properties DOI
Feng Zhao,

Jiaqi Liu,

Yueqi Lu

et al.

Biotechnology Journal, Journal Year: 2025, Volume and Issue: 20(2)

Published: Feb. 1, 2025

ABSTRACT Skin wound repair, a highly integrated and overlapping complex process, is susceptible to infection, excessive inflammation, high oxidative stress, which can prolong the healing time or even lead chronic wound. Meanwhile, single‐layer hydrogels are unavoidably dehydrated usually due water evaporation, not conducive healing. Therefore, bilayer hydrogel dressing composed of gelatin (G) sodium alginate (A) loaded with ciprofloxacin (C) curcumin (Cur) was manufactured by extrusion 3D bioprinting technology in this study, denoted as GACCur. The experimental results showed that 50 µg/mL Cur (GACCur50) had excellent antibacterial properties antioxidative activity 54.35 ± 0.48% DPPH scavenging ratio. In addition, GACCur50 exhibited capacity mitigate polarization inflammatory cells toward pro‐inflammatory states, observably reducing expression pertinent cytokines. Furthermore, also good biocompatibility assessed live‐dead fluorescent staining, scanning electron microscopy (SEM), CCK‐8 test. promising for

Language: Английский

Citations

0
Bioinspired Suction-Driven Strategies with Nanoscale Skin-Controllable Adhesive Architectures for Efficient Liquid Formulated Transdermal Patches DOI

Dohyun Lim,

Minwoo Song,

Minjin Kim

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

For highly efficient and precise drug release, transdermal delivery systems (TDDS) have recently evolved through the combination of intelligent material-based structures with various active components. These strategies are an effort to overcome significant difficulties in delivering large molecule drugs nanomaterials due physical barrier skin, especially stratum corneum, traditional TDDS. Interestingly, multiscale suction-driven architectures (SDAs) inspired by bioinspired suction adhesion mechanisms provided innovative solutions these challenges. employ negative pressure enhance nanoscale skin-controllable skin adhesion, temporarily bypass barrier, facilitate deep penetration therapeutic agents, thereby, achieving goals increasing efficiency maximizing user convenience as a minimal invasive, needle-free platform. This review provides comprehensive overview patches emphasizes their integration multifunctional materials achieve stable controlled release. Next, we present cost-effective user-friendly patch devices optimization cupping without incorporation additional devices. Furthermore, that optimize need for Potential SDAs localized systemic challenging complex well future perspectives, discussed, along directions more patient-centric solutions.

Language: Английский

Citations

0
Self‐Coacervation of Oligo(ethylene glycol) and Oligo(2‐ethyl‐2‐oxazoline)‐Based Double Hydrophilic Brush Block Copolymers in Aqueous Solution DOI Creative Commons

Niamh Bayliss,

Matilde Concilio,

Alexander Plucinski

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Coacervates are a highly relevant class of structures formed via liquid–liquid phase separation and new coacervate‐forming polymers sought after. Here, the formation simple coacervate droplets from double hydrophilic block copolymer (DHBC) with combination poly(oligo ethylene glycol methacrylate) (POEGMA) 2‐ethyl‐2‐oxazoline (POEtOx) without use external triggers or charges is shown. At high concentration 25 wt.%, DHBC forms sizes in low micrometre range. The have relatively stability over long period time only minor coalescence observed after 4 weeks. concentrations, no coacervation observed. Furthermore, copolymers monomers also do not show clearly indicating that architecture required to form desired structures. addition guest biomacromolecules at concentrations shows specific partitioning behaviour preference for polymer aqueous phase. enrichment observed, line common water‐in‐water (w/w) emulsions. These findings constitute direction systems interest biotechnology, synthetic cell environment mimics drug delivery.

Language: Английский

Citations

0
Highly thermoelectric ionic hydrogel similar to fever cooling patch applied to lithium-ion battery cooling and intelligent overheating warning DOI
Xichen Xu, Bihe Yuan, Yue Chen

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162924 - 162924

Published: April 1, 2025

Language: Английский

Citations

0
Stochastic stability and global dynamics of a mathematical model for drug use: Statistical sensitivity analysis via PRCC DOI Creative Commons
Sara Soulaimani, Abdelilah Kaddar, Fathalla A. Rihan

et al.

Partial Differential Equations in Applied Mathematics, Journal Year: 2024, Volume and Issue: unknown, P. 100964 - 100964

Published: Oct. 1, 2024

Language: Английский

Citations

2
Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing DOI Creative Commons
Mengyang Liu, Manisha Sharma, Guo‐Liang Lu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 17(1), P. 4 - 4

Published: Dec. 24, 2024

Background: Skin ageing, driven predominantly by oxidative stress from reactive oxygen species (ROS) induced environmental factors like ultraviolet A (UVA) radiation, accounts for approximately 80% of extrinsic skin damage. L-glutathione (GSH), a potent antioxidant, holds promise in combating UVA-induced stress. However, its instability and limited penetration through the stratum corneum hinder topical application. This study introduces novel solid lipid nanoparticle (SLN)-enriched hydrogel designed to enhance GSH stability, penetration, sustained release anti-ageing applications. Methods: GSH-loaded SLNs were prepared via double-emulsion technique optimized using factorial design. These incorporated into 1-3% (w/v) Carbopol hydrogels produce semi-solid formulation. The hydrogel's characteristics, including morphology, mechanical rheological properties, drug release, antioxidant activity, cytotoxicity, evaluated. Results: SEM FTIR confirmed uniform dispersion within hydrogel. formulation exhibited desirable gel strength (5.1 ± 0.5 g), spreadability (33.6 1.9 g·s), pseudoplasticity, elasticity. In vitro studies revealed biphasic profile, with over 72 h 70% cumulative release. significantly improved capacity, protecting human fibroblasts enhancing cell viability. Stability indicated that 4 °C was optimal storage three months. Notably, enhanced 3.7-fold. Conclusions: SLN-enriched effectively improves delivery efficacy, providing promising platform other bioactive compounds similar challenges.

Language: Английский

Citations

2
Exosome-Integrated Hydrogels for Bone Tissue Engineering DOI Creative Commons

Hee Sook Hwang,

Chung‐Sung Lee

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 762 - 762

Published: Nov. 23, 2024

Exosome-integrated hydrogels represent a promising frontier in bone tissue engineering, leveraging the unique biological properties of exosomes to enhance regenerative capabilities hydrogels. Exosomes, as naturally occurring extracellular vesicles, carry diverse array bioactive molecules that play critical roles intercellular communication and regeneration. When combined with hydrogels, these can be spatiotemporally delivered target sites, offering controlled sustained release therapeutic agents. This review aims provide comprehensive overview recent advancements development, application exosome-integrated for highlighting their potential overcome current challenges Furthermore, explores mechanistic pathways by which embedded within facilitate repair, encompassing regulation inflammatory pathways, enhancement angiogenic processes, induction osteogenic differentiation. Finally, addresses existing challenges, such scalability, reproducibility, regulatory considerations, while also suggesting future directions research this rapidly evolving field. Thus, we hope contributes advancing development next-generation biomaterials synergistically integrate exosome hydrogel technologies, thereby enhancing efficacy

Language: Английский

Citations

1