Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115119 - 115119
Опубликована: Окт. 28, 2023
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130645 - 130645
Опубликована: Март 7, 2024
Hyaluronic acid (HA), a biodegradable, biocompatible and non-immunogenic therapeutic polymer is key component of the cartilage extracellular matrix (ECM) has been widely used to manage two major types arthritis, osteoarthritis (OA) rheumatoid arthritis (RA). OA joints are characterized by lower concentrations depolymerized (low molecular weight) HA, resulting in reduced physiological viscoelasticity, while RA, associated immune cells over-expressed with various cell surface receptors such as CD44. Due HA's inherent viscoelastic property its ability target CD44, there surge interest developing HA-based systems deliver bioactives (drugs biologics) arthritis. Considering benefits HA management potential advantages novel delivery systems, bioactive through beginning display improved outcomes over only treatment. The include enhanced uptake due receptor-mediated targeting, prolonged retention synovium, expressions proinflammatory mediators, regeneration, drug toxicity sustained release, cost-effective This review provides an underlying rationale prepare use for applications. With special emphasis given preclinical/clinical results, this article reviews bioactive-loaded particulate carriers (organic inorganic), gels, scaffolds polymer-drug conjugates that have reported treat RA. Furthermore, identifies several challenges valuable suggestions address them. Various developments, strategies described may guide formulation scientists optimize effective approach effectively.
Язык: Английский
Процитировано
17
Pharmaceutics, Год журнала: 2022, Номер 14(3), С. 563 - 563
Опубликована: Март 3, 2022
Rheumatoid arthritis (RA) is a chronic inflammatory illness affecting the joints. The characteristic of RA gradual joint deterioration. Current treatment alleviates signs such as inflammation and pain substantially slows progression disease. In this study, we aimed to boost transdermal delivery berberine (a natural product) by encapsulating it in chitosan, surface-modified bilosomes nanogel for better management RA. chitosan-coated loaded with (BER-CTS-BLS) were formulated according thin-film hydration approach optimized various causal variables, considering effect lipid, sodium deoxycholate, chitosan concentrations on size particles, entrapment, surface charge. BER-CTS-BLS has 202.3 nm mean diameter, 83.8% 30.8 mV exhibited delayed-release profile vitro increased skin permeability ex vivo. Additionally, histological examination revealed that BLS had no irritating effects skin. Furthermore, ability reduce was evaluated rats carrageenan-induced paw edema. Our results demonstrate group treated topical gel dramatic reduction rat edema swelling percentage reach 24.4% after 12 h, which lower than other groups. Collectively, containing have emerged promising therapeutic control inflammation.
Язык: Английский
Процитировано
54
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 89, С. 105066 - 105066
Опубликована: Окт. 18, 2023
It is increasingly urgent to develop new therapeutic systems combat the spreading and evolution of various pathologies globally. Nonspecific therapies and/or insufficient medication biodistribution might hinder patient's recovery. In this sense, a targeted controlled delivery biomolecules allows overcoming limitations conventional systems, taking user one step closer successful treatment disease. Hydrogels have been highlighted for their drug abilities, particularly tunable properties, like hydration capacity, biodegradability, release kinetics, etc., that can be adjusted desired needs. Additionally, they produced from either natural synthetic polymers, with natural-origin sources providing exceptional features biodegradation acceptable integration in biological systems. One those polymers pullulan, biodegradable, biocompatible hemocompatible material, multiple uses biomedicine. Investigations into pullulan-based hydrogels progressively increased over last few decades. This review addresses pullulan biomedical engineering, emphasizing its properties processing hydrogel original or derivative forms.
Язык: Английский
Процитировано
24
Pharmaceutics, Год журнала: 2022, Номер 14(3), С. 540 - 540
Опубликована: Фев. 28, 2022
Rheumatoid arthritis (RA) and osteoarthritis (OA) are disabling musculoskeletal disorders that affect joints cartilage may lead to bone degeneration. Conventional delivery of anti-arthritic agents is limited due short intra-articular half-life toxicities. Innovations in polymer chemistry have led advancements hydrogel technology, offering a versatile drug platform exhibiting tissue-like properties with tunable loading high residence time This review discusses the advantages drawbacks polymeric materials along their modifications as well applications for fabricating hydrogels loaded therapeutic (small molecule drugs, immunotherapeutic agents, cells). Emphasis given biological potentialities hybrid systems/micro-and nanotechnology-integrated promising tools. Applications facile tuning loading, maintaining long-term release, consequently improving outcome patient compliance detailed. also suggests advantages, challenges, future perspectives potential alter landscape currently available treatment modalities.
Язык: Английский
Процитировано
33
Drug Delivery, Год журнала: 2022, Номер 29(1), С. 882 - 888
Опубликована: Март 11, 2022
Purpose Rheumatoid arthritis, a chronic and progressive inflammation condition in the joints, has significantly reduced patient quality of life expectancy. Crucially, there is no complete therapy for this disease, current treatments possess numerous side effects. Thus, novel therapeutic approach necessary. To that end, study developed silk fibroin in-situ hydrogel containing Sesbania sesban L. extract, plant with high anti-inflammatory actions are beneficial rheumatoid arthritis treatments.Methods The hydrogels were manufactured using simple method spontaneous gelation at different temperature. gel properties morphology, time, viscosity, strength, stability, drug loading capacity, release rate, in-vitro activity investigated appropriate methods.Results optimal formulation had highly porous structure, time 0.5 h room temperature bodily 37 °C, viscosity 2530 ± 50 cP, strength 1880.14 35.10 g, physical stability >6 months. Moreover, contained leaf extract total phenolic content 92.8 8.30 mg GAE/g, sustained rate >20 dạys, followed Higuchi model. Regarding activities, all formulations nontoxic to RAW 264.7 cell line demonstrated comparable free terms NO reduction levels.Conclusion Conclusively, systems possessed potential be further become prospective treatment.
Язык: Английский
Процитировано
30
Biomaterials, Год журнала: 2023, Номер 303, С. 122390 - 122390
Опубликована: Ноя. 10, 2023
Язык: Английский
Процитировано
13
Materials Today Communications, Год журнала: 2024, Номер 41, С. 110208 - 110208
Опубликована: Авг. 27, 2024
Язык: Английский
Процитировано
5
Pharmaceuticals, Год журнала: 2022, Номер 15(9), С. 1106 - 1106
Опубликована: Сен. 5, 2022
The oral delivery of diclofenac sodium (DNa), a non-steroidal analgesic, anti-inflammatory drug, is associated with various gastrointestinal side effects. aim the research was to appraise potential transdermal DNa using bilosomes as vesicular carrier (BSVC) in inflamed paw edema. DNa-BSVCs were elaborated thin-film hydration technique and optimized 31.22 multilevel categoric design Design Expert® software 10 (Stat-Ease, Inc., Minneapolis, MI, USA). effect formulation variables on physicochemical properties BSVC, well optimal selection, investigated. BSVCs evaluated for parameters including entrapment efficiency (EE%), vesicle size (VS), zeta (ZP) permeation studies. BSVC characterized vitro release, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) incorporated into hydrogel base. DNa-BSVC gel effectiveness assessed vivo carrageenan-induced edema animal model via cyclooxygenase 2 (COX-2), interleukin 6 (IL-6), Hemooxygenase 1 (HO-1) nuclear factor-erythroid factor2-related factor (Nfr-2) that potentiate anti-oxidant activity coupled histopathological investigation. resulting vesicles presented VS from 120.4 ± 0.65 780.4 0.99 nm, EE% 61.7 3.44 93.2 2.21%, ZP -23.8 2.65 -82.1 12.63 mV 582.9 32.14 1350.2 45.41 µg/cm2. nano-scaled spherical non-overlapped bands their constituents FTIR. Optimized has superior skin permeability ex approximately 2.5 times greater than solution. Furthermore, histological investigation discovered formed had no irritating properties. It found suppressed changes oxidative inflammatory mediators IL-6 consequently enhanced Nrf2 HO-1 levels. Moreover, reduction percent by about three-folds confirmed alterations. results revealed could be promising drug system boost efficacy enhancing suppressing inflammation rat
Язык: Английский
Процитировано
21
Gels, Год журнала: 2022, Номер 8(11), С. 723 - 723
Опубликована: Ноя. 8, 2022
The intra-articular administration of conventional drug solutions or dispersions in joint diseases such as osteoarthritis has a relatively short retention time and, therefore, limited therapeutic effect. Thermosensitive polymer that exhibit sol–gel phase transition near body temperature after injection can prolong by providing depot from which the release is sustained while relieving inflammation and preventing degradation complex. hydrogels have recent times garnered considerable attention therapeutics osteoarthritis. Among stimuli-responsive gelling systems, most research focused on thermosensitive hydrogels. These gels are preferred over other stimuli-sensitive since they well-controlled situ properties also easier to load with drugs. Temperature-sensitive polymers, block copolymers poloxamers, frequently used modify their gelation properties, usually combination polymers. They compatible drugs but may pose formulation challenges terms low-response time, highly fragile nature, low biocompatibility. stability biodegradability implant control rate treatment efficacy. This review stresses application disorders summarizes developments for application, including incorporation nanoparticles. hydrogel composition, mechanisms, involved storage discussed.
Язык: Английский
Процитировано
19
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 254, С. 127708 - 127708
Опубликована: Ноя. 1, 2023
Язык: Английский
Процитировано
12