Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4417 - 4441

Опубликована: Май 26, 2023

Rheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate. Several drugs have been used for the treatment of rheumatoid arthritis, but their use limited by suboptimal bioavailability, serious adverse effects, nonnegligible first-pass effects. In contrast, transdermal drug delivery systems (TDDSs) can avoid these drawbacks improve patient compliance, making them promising option (RA). Of course, TDDSs also face unique challenges, as physiological barrier skin makes somewhat limited. To overcome this maximize efficiency, evolved in terms principle facilitation technology, different generations derived, which significantly improved efficiency even achieved individualized controlled delivery. review, we summarize systems, corresponding strategies, applications RA.

Язык: Английский

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The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery

Molecules, Год журнала: 2025, Номер 30(5), С. 1181 - 1181

Опубликована: Март 6, 2025

Nano-drug delivery systems provide targeted solutions for addressing various drug challenges, leveraging nanotechnology to enhance solubility and permeability. Liposomes, explored several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or other surfactants, along with amphiphilic bile salts, they show superior stability pharmacokinetic behavior comparison conventional vesicular (liposomes niosomes). Bilosomes skin penetration, fluidize the stratum corneum, improve stability. In applications, bilosomes overcome drawbacks, offering improved bioavailability, controlled release, reduced side effects. Vaccines using demonstrate efficacy, intranasal, inhalation, ocular, buccal applications delivery, targeted, efficient, activities. Formulations vary based on active substances optimization techniques, showcasing versatility potential across diverse routes. Therefore, aim this comprehensive review was critically explore state-of-the-art therapeutic applications.

Язык: Английский

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Tailoring of Novel Bile Salt Stabilized Vesicles for Enhanced Transdermal Delivery of Simvastatin: A New Therapeutic Approach against Inflammation

Polymers, Год журнала: 2023, Номер 15(3), С. 677 - 677

Опубликована: Янв. 29, 2023

Simvastatin (SMV), a cholesterol-lowering agent, has antioxidant and anti-inflammatory effects. Nevertheless, the oral use of SMV is linked with poor systemic bioavailability owing to its limited aqueous solubility extensive first-pass metabolism. The aim this study was evaluate feasibility transdermal delivery using bile salt stabilized vesicles (bilosomes) for enhancing potential SMV. SMV-loaded bilosomes (SMV-BS) were prepared by thin film hydration technique optimized 33 Box–Behnken design. fabricated SMV-BS assessed vesicle size, entrapment efficiency (% EE) cumulative drug release. formula incorporated into HPMC gel investigated physical properties, ex vivo permeation, in pharmacokinetic inflamed paw edema rat model. showed size 172.1 ± 8.1 nm % EE 89.2 1.8%. In addition, encapsulating within bilosomal remarkably sustained release over 12 h, compared plain suspension. Furthermore, three-fold enhancement flux, Most importantly, relative ~2-fold ~3-fold higher than those suspension gel, respectively. carrageenan-induced model, induced potent effect, as evidenced remarkable reduction edema, which comparable that standard drug, indomethacin. Collectively, might represent plausible system could enhance activity boosting skin permeation bioavailability.

Язык: Английский

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Formulation Development, Optimization by Box–Behnken Design, and In Vitro and Ex Vivo Characterization of Hexatriacontane-Loaded Transethosomal Gel for Antimicrobial Treatment for Skin Infections

Gels, Год журнала: 2023, Номер 9(4), С. 322 - 322

Опубликована: Апрель 11, 2023

There are many different infections and factors that can lead to skin illnesses, but bacteria fungi the most frequent. The goal of this study was develop a hexatriacontane-loaded transethosome (HTC-TES) for treating conditions caused by microbes. HTC-TES developed utilizing rotary evaporator technique, Box-Behnken design (BBD) utilized improve it. responses chosen were particle size (nm) (Y1), polydispersity index (PDI) (Y2), entrapment efficiency (Y3), while independent variables lipoid (mg) (A), ethanol (%) (B), sodium cholate (C). optimized TES formulation with code F1, which contains (A) 90, (B) 25, (C) 10, chosen. Furthermore, generated used research on confocal laser scanning microscopy (CLSM), dermatokinetics, in vitro HTC release. results reveal ideal HTC-loaded had following characteristics: 183.9 nm, 0.262 mV, -26.61 87.79% size, PDI, efficiency, respectively. An release found rates conventional suspension 74.67 ± 0.22 38.75 0.23, hexatriacontane from fit Higuchi model best, Korsmeyer-Peppas indicates followed non-Fickian diffusion. By having higher negative value cohesiveness, produced gel demonstrated its stiffness, whereas good spreadability indicated better application surface. In dermatokinetics study, it discovered considerably increased transport epidermal layers (p < 0.05) when compared (HTC-CFG). CLSM rat treated rhodamine B-loaded deeper penetration 30.0 µm comparison hydroalcoholic B solution (0.15 µm). determined be an effective inhibitor pathogenic bacterial growth (S. aureus E. coli) at concentration 10 mg/mL. It both strains susceptible free HTC. According findings, employed enhance therapeutic outcomes through antimicrobial activity.

Язык: Английский

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Formulation of Miconazole-Loaded Chitosan–Carbopol Vesicular Gel: Optimization to In Vitro Characterization, Irritation, and Antifungal Assessment

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 581 - 581

Опубликована: Фев. 8, 2023

Miconazole nitrate (MN) is a poorly water-soluble and antifungal drug used for fungal infections. The present research work was designed to develop topical MN-loaded bilosomes (BSs) the improvement of therapeutic efficacy. MZBSs were prepared by using thin-film hydration method further optimized Box-Behnken statistical design (BBD). miconazole bilosome (MZBSo) showed nano-sized vesicles, low polydispersity index, high entrapment efficiency, zeta potential. Further, MZBSo incorporated into gel carbopol 934P chitosan polymers. selected (MZBSoG2) demonstrated an acceptable pH (6.4 ± 0.1), viscosity (1856 21 cP), spreadability (6.6 0.2 cm2). Compared (86.76 3.7%), MZBSoG2 significantly (p < 0.05) slower release (58.54 4.1%). found be non-irritant because it achieved score zero (standard score) in HET-CAM test. It also exhibited significant activity compared pure MZ against Candida albicans Aspergillus niger. stability study results no changes after testing under accelerated conditions. MZ-loaded gels could serve as effective alternative carriers improving

Язык: Английский

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Emerging Trends in Bilosomes as Therapeutic Drug Delivery Systems

Pharmaceutics, Год журнала: 2024, Номер 16(6), С. 697 - 697

Опубликована: Май 23, 2024

In recent years, there has been a notable surge in the utilization of stabilized bile acid liposomes, chemical conjugates, complexes, mixed micelles, and other drug delivery systems derived from acids, often referred to as bilosomes. The molecular structure interactions these amphiphilic compounds provide distinctive captivating subject for investigation. enhanced stability new generation bilosomes inside gastrointestinal system results prevention degradation an improvement mucosal penetration. These characteristics render be prospective nanocarrier pharmaceutical administration, prompting researchers investigate their potential domains. This review paper discusses that have emerged viable modality realm significant promise use across several Moreover, this underscores need additional investigation advancement order comprehensively comprehend uses effectiveness field administration. study explores current scholarly attention on carriers delivery. Therapeutic areas where shown outstanding performance terms are outlined graphical abstract.

Язык: Английский

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Cross-Linked Alginate Dialdehyde/Chitosan Hydrogel Encompassing Curcumin-Loaded Bilosomes for Enhanced Wound Healing Activity

Pharmaceutics, Год журнала: 2024, Номер 16(1), С. 90 - 90

Опубликована: Янв. 9, 2024

The current study aimed to fabricate curcumin-loaded bilosomal hydrogel for topical wound healing purposes, hence alleviating the poor aqueous solubility and low oral bioavailability of curcumin. Bilosomes were fabricated via thin film hydration technique using cholesterol, Span

Язык: Английский

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Therapeutic potential of cationic bilosomes in the treatment of carrageenan-induced rat arthritis via fluticasone propionate gel

International Journal of Pharmaceutics, Год журнала: 2023, Номер 635, С. 122776 - 122776

Опубликована: Фев. 23, 2023

Язык: Английский

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Investigating the efficacy of mirtazapine-embedded invasomal gel nanocarriers via I-optimal design for management of atopic dermatitis

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 92, С. 105395 - 105395

Опубликована: Янв. 23, 2024

Язык: Английский

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Evaluation of types and concentration of bile salts impact on physical properties of nisoldipine-loaded bilosomes

Pharmacia, Год журнала: 2024, Номер 71, С. 1 - 7

Опубликована: Фев. 9, 2024

Background : Bilosomes are lipid vesicles that exhibit flexibility and deformability. They consist of phospholipids amphiphilic bile salts. Compared to the normal vesicular systems such as liposomes niosomes, bilosomes provide several notable advantages, including simplified manufacturing, cost-effectiveness, enhanced stability. Aim The main objective present work was evaluate effect different salts on physical properties include entrapment efficiency, vesicle size, polydispersity index(PDI). In addition, in vitro drug release for nisoldipine (NSD) loaded evaluated. Methods Nisoldipine-loaded were made using a thin film hydration technique. Cholesterol along with surfactant (span 60) employed, formulation also contained salts, sodium deoxycholate (SDC), glycocholate (SGC), taurocholate (STC). Results developed NSD exhibited an efficiency ranging from 44.2 ± 0.3 82.36 0.80% size diameter nanometric dimensions (166 1.83 237.8 3.3 nm). An in-vitro study revealed formulas prepared SDC showed higher than SGC STC formulas. Increasing salt amount 5 mg 10 increases increasing size. Further increase led decreased increased gives best result terms acceptable provides largest particle due its high molecular weight compared SDC. Conclusion component is better suited manufacturing bilosomes. This because this yields results regarding nano prolonged release.

Язык: Английский

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