Pegylated Retinoate Prodrug Self-Assembled Nanomicelles Loaded with Triptolide for Targeting Treatment of Rheumatoid Arthritis and Side Effect Attenuation

Опубликована: Янв. 1, 2025

Язык: Английский

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A comprehensive review of hydrogel strategies for repairing peripheral nerve injuries

Brain‐X, Год журнала: 2025, Номер 3(1)

Опубликована: Фев. 8, 2025

Abstract As an etiological factor underlying physical and mental disability in humans, peripheral nerve injuries (PNIs) can induce pain, sensory impairment, disability. Despite their regenerative ability, nerves cannot self‐repair after severe defects. While grafting is the gold standard for treatment of PNIs, it limited by graft versus host reactions, surgical complications, donor nerves. field material science continues to develop, hydrogels have been proposed use PNI repair biomodification, targeted modification, or loading with biological factors cells. This article reviewed research advances used repair, including simple composite functionalized loaded Based on findings from these reviews, we determined that further clarification mechanisms action modulating cellular functions necessary. In addition, there a need explore synergistic effect novel other biological, physical, biochemical factors. clinical trials are still limited, scientific efforts expected promote application repair.

Язык: Английский

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Injectable depot-forming hydrogels for long-acting drug delivery

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 241 - 272

Опубликована: Янв. 1, 2025

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PEGylated retinoate prodrug self-assembled nanomicelles loaded with triptolide for targeting treatment of rheumatoid arthritis and side effect attenuation

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 251, С. 114618 - 114618

Опубликована: Март 12, 2025

Язык: Английский

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Emerging insights of peptide-based nanotherapeutics for effective management of rheumatoid arthritis

Life Sciences, Год журнала: 2022, Номер 312, С. 121257 - 121257

Опубликована: Ноя. 30, 2022

Язык: Английский

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Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 9984 - 9984

Опубликована: Сен. 16, 2024

Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage promotion tissue engineering, offering key advantages such enhanced integration therapeutic potential. This comprehensive review navigates landscape adhesive repair, discussing identified challenges, shortcomings current treatment options, unique hydrogel products scaffolds. While emphasizing critical need situ lateral with surrounding tissues, we dissect limitations outline future perspectives scaffolds repair. Moreover, examine translation pathway regulatory considerations specific hydrogels. Overall, this synthesizes insights knowledge gaps highlights directions research regarding hydrogel-based devices advancing engineering.

Язык: Английский

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Carboxymethyl chitosan/dialdehyde quaternized pullulan self-healing hydrogel loaded with tranexamic acid for rapid hemostasis

Carbohydrate Polymers, Год журнала: 2024, Номер 348, С. 122817 - 122817

Опубликована: Окт. 8, 2024

Язык: Английский

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Therapeutic application of hydrogels for bone-related diseases

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Сен. 12, 2022

Bone-related diseases caused by trauma, infection, and aging affect people’s health quality of life. The prevalence bone-related has been increasing yearly in recent years. Mild bone can still be treated with conservative drugs cured confidently. However, serious injuries large-scale fractures, tumors, other are challenging to heal on their own. Open surgery must used for intervention. treatment method also faces the problems a long cycle, high cost, side effects. Studies have found that hydrogels attracted much attention due good biocompatibility biodegradability show great potential treating diseases. This paper mainly introduces properties preparation methods hydrogels, reviews application (including defects, fracture, cartilage injuries, osteosarcoma) We put forward suggestions according current development status, pointing out new direction developing high-performance more suitable

Язык: Английский

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Advancement in nanotechnology for treatment of rheumatoid arthritis: scope and potential applications

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 396(10), С. 2287 - 2310

Опубликована: Май 11, 2023

Язык: Английский

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Thermosensitive Injectable Hydrogels for Intra-Articular Delivery of Etanercept for the Treatment of Osteoarthritis

Gels, Год журнала: 2022, Номер 8(8), С. 488 - 488

Опубликована: Авг. 5, 2022

The intra-articular administration of drugs has attracted great interest in recent decades for the treatment osteoarthritis. use modified also years because their demonstrated encouraging results. objective this work was to prepare injectable-thermosensitive hydrogels Etanercept (ETA), an inhibitor tumor necrosis factor-α. Hydrogels were prepared from physical mixture chitosan and Pluronic F127 with β-glycerolphosphate (BGP). Adding system reduced gelation time morphology resulting material. In vitro studies carried out determine cytocompatibility human chondrocyte line C28/I2. release study showed that incorporation BGP into markedly ETA. vivo studies, it verified remained inside implantation site joint until end study. Furthermore, ETA highly concentrated blood mice 48 h after loaded material injected. Histological investigation osteoarthritic knees promotes cartilage recovery mice. results demonstrate potential ETA-loaded injectable localized joints.

Язык: Английский

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