International Journal of Life Science and Pharma Research,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 1, 2023
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disorder
characterized
by
inflammation
and
damage
to
joints
andtissues.
While
previous
reviews
exist,
there
still
needs
be
more
in
understanding
risk
factors,
diagnostic
methods,
treatmentoptions.
This
review
aims
fill
these
gaps
providing
comprehensive
overview
of
recent
advancements
the
field.
To
addressthe
limitations
reviews,
this
article
incorporates
updated
information
on
including
influence
ofenvironmental
factors
industrialized
nations.
It
highlights
significance
early
RA
diagnosis
emphasizes
utility
ofdynamic
contrast-enhanced
magnetic
resonance
imaging
(DCE-MRI)
for
effective
disease
management.
Moreover,
reviewintroduces
innovative
nanotechnology-based
treatment
approaches
RA.
explores
potential
gold
nanoparticles,
carbonnanotubes,
polymer-based
nanomedicine,
nanoliposomes
targeting
specific
inflammatory
sites
improving
treatmenteffectiveness.
present
an
up-to-date
analysis
RA,
bridging
literature
byintroducing
novel
techniques
exploring
emerging
modalities.
By
synthesizing
current
knowledge
andoutlining
future
research
prospects,
advance
rheumatoid
arthritis.Additionally,
discusses
systemic
complications
associated
with
such
as
vasculitis
Feltysyndrome.
also
sheds
light
long-term
consequences
untreated
need
joint
replacementsurgery
(arthroplasty)
splenectomy.
aspects,
enhance
theholistic
guide
toward
improved
management
patient
outcomes.
Abstract
In
the
realm
of
therapeutic
peptides,
tremendous
progress
has
been
achieved
in
last
two
decades.
The
building
block
peptides
that
is,
‘Amino
Acid’
modified
by
various
chemical
modifications
such
as
side‐chain
alteration
linear
cyclization,
back‐bone
modification,
pro‐drug
moiety,
conjugation
with
heterocycles,
and
natural
products
to
make
a
foremost
candidate
drug.
Since
advent
insulin
1922,
have
immensely
affected
development
pharmaceutical
industry
giving
rise
peptide‐based
drug
industry.
recent
years,
having
antimicrobial,
antiviral,
anti‐tumor,
anti‐inflammatory,
anti‐aging,
antioxidant
properties
developed.
Also,
it
now
entered
potent
field
oncology
also
become
valuable
tool
radiolabeled
peptide
for
detection
diseases.
Generally,
were
extracted
from
sources
olden
days,
but
presently
work
is
directed
towards
finding
alternate
sustainable
ways
developing
synthetic
peptides.
present
review
covers
discussion
about
historic
evaluation
available
effective
processes,
current
advancements,
use
bioinformatic
tools,
computational
strategies,
methodology
overcome
barrier
making
future
world.
Current Pharmaceutical Design,
Год журнала:
2023,
Номер
29(13), С. 984 - 1001
Опубликована: Апрель 1, 2023
Abstract:
Rheumatoid
arthritis
(RA)
is
the
most
common
form
of
chronic
inflammatory
autoimmune
disease
characterized
by
synovitis,
synovial
proliferation,
and
cellular
infiltration.
Further,
it
leads
to
bone
erosion,
destruction
articular
cartilage,
intense
joint
pain,
swelling,
a
high
rate
disability,
causing
an
immense
load
on
human
health.
If
identified
early
on,
patient
has
continuous
timely
treatment,
many
patients
can
achieve
remission.
Although
research
in
RA
made
considerable
progress,
conventional
therapies
are
still
popular
treatment
options
for
people
with
RA.
But,
hampered
various
drawbacks,
including
higher
doses,
low
solubility
permeability,
poor
bioavailability,
level
first-pass
metabolism,
adaptive
tolerance
(ATT),
long-term
drug
use.
These
drawbacks
result
severe
side
effects
toxicity
patients.
Advances
polymer
science
application
nanotechnology
delivery
systems
have
provided
new
possibilities
developing
new-generation
smart
(SDDSs).
The
shortcomings
non-specific
distribution
uncontrollable
release
traditional
motivated
creation
next-generation
SDDSs.
methods
significantly
changed
course
Such
improve
virtue
their
multi-functionality
targeting
capabilities.
ultimate
objective
SDDSs
deliver
medication
at
optimal
time
precise
dosage
efficiency
specificity
targeted
site
(such
as
cells,
tissues,
organs),
which
aid
adhere
better
therapy.
This
review
highlights
discusses
along
available
management.
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2024,
Номер
unknown, С. 1 - 29
Опубликована: Янв. 29, 2024
The
emergence
of
new
SARS-CoV-2
variants
has
raised
concerns
about
the
effectiveness
COVID-19
vaccines.
To
address
this
challenge,
small-molecule
antivirals
have
been
proposed
as
a
crucial
therapeutic
option.
Among
potential
targets
for
anti-COVID-19
therapy,
main
protease
(Mpro)
is
important
due
to
its
essential
role
in
virus's
life
cycle
and
high
conservation.
substrate-binding
region
core
proteases
various
coronaviruses,
including
SARS-CoV-2,
SARS-CoV,
Middle
East
respiratory
syndrome
coronavirus
(MERS-CoV),
could
be
used
generation
inhibitors.
Various
drug
discovery
methods
employed
diverse
range
strategies,
targeting
both
monomeric
dimeric
forms,
repurposing,
integrating
virtual
screening
with
high-throughput
(HTS),
structure-based
design,
each
demonstrating
varying
levels
efficiency.
Covalent
inhibitors,
such
Nirmatrelvir
MG-101,
showcase
robust
high-affinity
binding
Mpro,
exhibiting
stable
interactions
confirmed
by
molecular
docking
studies.
Development
effective
antiviral
drugs
imperative
pandemic
situations.
This
review
explores
recent
advances
search
Mpro
inhibitors
application
artificial
intelligence
(AI)
design.
AI
leverages
vast
datasets
advanced
algorithms
streamline
design
identification
promising
AI-driven
methods,
docking,
predictive
modeling,
are
at
forefront
identifying
candidates
therapy.
In
time
when
potentially
threat
global
health,
quest
potent
solutions
critical
inhibiting
virus.
Gels,
Год журнала:
2025,
Номер
11(2), С. 136 - 136
Опубликована: Фев. 15, 2025
As
a
chronic
systemic
autoimmune
disease,
rheumatoid
arthritis
(RA)
not
only
damages
joints
and
other
organs
or
systems
throughout
the
body
but
also
torments
patients'
physical
mental
health
for
long
time,
seriously
affecting
their
quality
of
life.
According
to
incomplete
statistics
at
present,
global
prevalence
RA
is
approximately
0.5-1%,
number
patients
increasing
year
by
year.
Currently,
drug
therapies
are
usually
adopted
treatment
RA,
such
as
non-steroidal
anti-inflammatory
drugs
(NSAIDs),
disease-modifying
antirheumatic
(DMARDs),
glucocorticoids/steroids,
so
on.
However,
traditional
therapy
has
problems
half-lives,
cycles
requiring
frequent
administration,
lack
specificity,
possible
adverse
reactions
(such
gastrointestinal
side
effects,
skin
stratum
corneum
barrier
damage,
toxicity),
which
greatly
restrict
RA.
In
order
improve
limitations
drug,
physical,
surgical
treatments
large
related
studies
on
have
been
carried
out.
Among
them,
hydrogels
widely
used
in
research
due
excellent
biocompatibility,
mechanical
properties,
general
adaptability.
For
example,
can
be
injected
into
synovial
cavity
fluid
reduce
wear
between
joints,
lubricate
avoid
surface
degradation.
This
article
reviews
applications
under
different
functions
situation
carriers
through
delivery
routes
confirms
outstanding
potential
great
significance.
The
aim
of
this
study
was
to
explore
the
bibliometric
analysis
nanomaterials-based
therapies
for
hepatocellular
carcinoma
as
a
means
assessing
current
state
development
and
future
trends
in
field.
Literature
on
nanomedicine
interactions
searched
from
core
database
Web
Science
visualisation
analyses
were
performed
using
VOSviewer,
CiteSpace
GraphPad
Prism
data
software.
We
focused
important
keywords,
countries,
authors,
affiliations,
journals,
literature
field
nanomaterials
HCC.
search
resulted
finalization
421
documents.
From
2008
2023,
research
HCC
has
developed
rapidly,
number
published
papers
steadily
increased,
increasing
by
about
2300%.
There
are
currently
57
countries
involved
area.
Among
them,
USA
had
strongest
international
cooperation
network
cooperated
most
closely
with
China.
Gene
delivery
carbon
nanotubes
early
immunotherapy
nanocarriers
recent
hotspots.
It
is
that
selection
drug
have
become
driving
carcinoma.
combination
traditional
imaging
techniques
such
MRI
can
improve
diagnosis
rate
Nanomaterials
achieve
precise
targeting
cancer
cells
encapsulating
drugs,
loading
bioactive
molecules
or
modifying
specific
ligands,
thus
significantly
improving
efficacy
effectively
reducing
adverse
reactions
therapy.
Most
antirheumatic
drugs
with
high
toxicity
exhibit
a
narrow
therapeutic
window
due
to
their
nonspecific
distribution
in
the
body,
leading
undesirable
side
effects
and
reduced
patient
compliance.
To
response
these
challenges,
prodrug-based
nanoparticulate
drug
delivery
systems
(PNDDS),
which
combines
prodrug
strategy
nanotechnology
into
single
system,
resulting
many
advantages,
including
stability
for
structure,
higher
loading
capacity
of
improving
target
activity
bioavailability,
reducing
untoward
effects.
PNDDS
have
gained
attention
as
method
relieving
arthralgia
syndrome
rheumatoid
arthritis
recent
years.
This
article
systematically
reviews
nanocarriers
rheumatism
treatment,
Nano
based
on
prodrug-encapsulated
nanomedicines
conjugate-based
nanomedicines.
It
provides
new
direction
clinical
treatment
arthritis.
Life,
Год журнала:
2024,
Номер
14(6), С. 751 - 751
Опубликована: Июнь 12, 2024
Rheumatoid
arthritis
(RA)
is
a
systemic
autoimmune
disorder
caused
by
inflammation
of
cartilaginous
diarthrodial
joints
that
destroys
and
cartilage,
resulting
in
synovitis
pannus
formation.
Timely
detection
effective
management
RA
are
pivotal
for
mitigating
inflammatory
consequences,
potentially
influencing
disease
progression.
Nuclear
medicine
using
radiolabeled
targeted
vectors
presents
promising
avenue
diagnosis
response
to
treatment
assessment.
Radiopharmaceutical
such
as
technetium-99m
(
