Developing and analyzing photo-crosslinkable cinnamoyl-modified pullulan hydrogels for drug delivery applications

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 100, С. 106092 - 106092

Опубликована: Авг. 23, 2024

Язык: Английский

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Chitosan-based self-healing thermosensitive hydrogel loaded with siHMGB1 for treatment of rheumatoid arthritis via macrophage repolarization

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137102 - 137102

Опубликована: Окт. 31, 2024

Язык: Английский

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Bioengineered Nanoparticles Loaded-Hydrogels to Target TNF Alpha in Inflammatory Diseases

Pharmaceutics, Год журнала: 2021, Номер 13(8), С. 1111 - 1111

Опубликована: Июль 21, 2021

Rheumatoid Arthritis (RA) is an incurable autoimmune disease that promotes the chronic impairment of patients’ mobility. For this reason, it vital to develop therapies target early inflammatory symptoms and act before permanent articular damage. The present study offers two novel based in advanced drug delivery systems for RA treatment: encapsulated chondroitin sulfate modified poly(amidoamine) dendrimer nanoparticles (NPs) covalently bonded monoclonal anti-TNF α antibody both Tyramine-Gellan Gum Gum/Silk Fibroin hydrogels. Using pro-inflammatory THP-1 (i.e., human monocytic cell line), therapy was tested inflammation vitro model under static dynamic conditions. Firstly, we demonstrated effective NP-antibody functionalization TNF-α capture. Upon encapsulation, NPs were released steadily over 21 days. Moreover, conditions, approaches presented good anti-inflammatory activity time, enabling retainment a high percentage TNF α. To mimic physiological conditions body, hydrogels evaluated dual-chamber bioreactor. Dynamic studies showed absent cytotoxicity cells significant reduction suspension 14 days Thus, developed approach potential use as personalized medicine obtain better therapeutic outcomes decreased adverse effects.

Язык: Английский

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Formulation and Characterization of Polymeric Cross-Linked Hydrogel Patches for Topical Delivery of Antibiotic for Healing Wound Infections

Polymers, Год журнала: 2023, Номер 15(7), С. 1652 - 1652

Опубликована: Март 27, 2023

Wound healing faces significant challenges in clinical settings. It often contains a series of dynamic and complex physiological processes. Instead creams, ointments solutions, alternative treatment approaches are needed. The main objective the study was to formulate bacitracin zinc-loaded topical patches as new therapeutic agent for potential wound healing. A free radical polymerization technique optimized synthesis. Polyethylene glycol-8000 (PEG-8000) chemically cross-linked with acrylic acid aqueous medium, using Carbopol 934 permeation enhancer tween 80 surfactant. Ammonium persulfate N,N'-Methylenebisacrylamide (MBA) were utilized initiator cross-linker. FTIR, DSC, TGA, SEM performed, evaluated swelling dynamics, sol-gel analysis, vitro drug release various media. Franz diffusion cell used study. Irritation drug-loaded also studied. characterization studies confirmed formation hydrogel network. highest observed formulations containing lowest concentrations. pH-sensitive behavior more swelling, across skin at pH 7.4. Fabricated showed no sign irritation or erythema by Draize scale. Faster fabricated compared marketed formulations. Therefore, such polymeric network can be promising technology speeding up minor injuries through enhanced deposition.

Язык: Английский

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Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115119 - 115119

Опубликована: Окт. 28, 2023

Язык: Английский

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