Pharmaceutics, Год журнала: 2022, Номер 14(12), С. 2827 - 2827
Опубликована: Дек. 16, 2022
Current advances in biomaterials processing and engineering for drug delivery have allowed interesting progressed biomedical field [...]
Язык: Английский
Bioactive Materials, Год журнала: 2022, Номер 23, С. 156 - 169
Опубликована: Ноя. 11, 2022
The skeletal system is responsible for weight-bearing, organ protection, and movement. Bone diseases caused by trauma, infection, aging can seriously affect a patient's quality of life. targeted biomaterials are suitable the treatment bone diseases. Biomaterials with bone-targeted properties improve drug utilization reduce side effects. A large number micro-nano materials have been developed. However, only few studies addressed hydrogel. size hydrogel makes it difficult to achieve systematic targeting. local still has significant prospects. Molecules in bone/cartilage extracellular matrix cells provide binding sites Drug delivery systems featuring microgels targeting key construction strategy Besides, injectable depot carrying drugs another strategy. In this review, we summarize through application environment, strategies disease applications. We hope article will reference development hydrogels. also could increase awareness materials.
Язык: Английский
Процитировано
122
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(17)
Опубликована: Фев. 7, 2024
Abstract Osteoarthritis is a degenerative joint disease characterized by cartilage deterioration and subsequent inflammatory changes in the underlying bone. Injectable hydrogels have emerged as promising approach for controlled drug delivery therapies. This review focuses on latest developments utilizing injectable vehicles targeted to promote repair regeneration. The pathogenesis of osteoarthritis discussed provide comprehensive understanding progression. Subsequently, various types used intra‐articular are discussed. Specifically, physically chemically crosslinked critically analyzed, with an emphasis their fabrication strategies capacity encapsulate release therapeutic agents manner. Furthermore, potential incorporating growth factors, anti‐inflammatory drugs, cells within these Overall, this offers guide navigating landscape hydrogel‐based therapeutics osteoarthritis.
Язык: Английский
Процитировано
27
Carbohydrate Polymers, Год журнала: 2024, Номер 334, С. 122008 - 122008
Опубликована: Март 4, 2024
Язык: Английский
Процитировано
20
Bioresource Technology, Год журнала: 2022, Номер 359, С. 127498 - 127498
Опубликована: Июнь 17, 2022
Язык: Английский
Процитировано
40
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(28), С. 33239 - 33249
Опубликована: Июль 3, 2023
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that so far incurable with long-term health risks. The high doses frequent administration for the available RA drug always lead to adverse side effects. Aiming at obstacles achieving effective treatment, we prepared macrophage cell membrane-camouflaged nanoparticles (M-EC), which were assembled from epigallocatechin gallate (EGCG) cerium(IV) ions. Due its geometrical similarity active metal sites of a natural antioxidant enzyme, EC possessed scavenge efficiency various types reactive oxygen species (ROS) nitrogen (RNS). membrane assisted M-EC in escaping immune system, being uptaken by cells, specifically binding IL-1β. After tail vein injection collagen-induced (CIA) mouse model, accumulated inflamed joints effectively repaired bone erosion cartilage damage rheumatoid relieving synovial inflammation erosion. It expected can not only pave new way designing metal–phenolic networks better biological activity but also provide more biocompatible therapeutic strategy treatment RA.
Язык: Английский
Процитировано
36
Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102241 - 102241
Опубликована: Фев. 21, 2024
Arthritis has become the most common joint disease globally. Current attention shifted towards preventing and exploring pharmaceutical surgical treatments for early-stage arthritis. M2 macrophages are known their anti-inflammatory properties ability to support cartilage repair, offering relief from Whereas, it remains a great challenge promote beneficial secretion of prevent progression Therefore, is warranted investigate new strategies that could use functions enhance its therapeutic effects. This review aims explore macrophage cell membrane-coated biomimetic nanovesicles targeted treatment arthritis such as osteoarthritis (OA), rheumatoid (RA), gouty (GA). Cell membrane-camouflaged nanovesicle attracted increasing attention, which successfully combine advantages both membrane delivered drug. We discuss roles in pathophysiology targets Then, preparation concluded. Moreover, we applications arthritis, OA, RA, GA. Taken together, hold tremendous prospect biomedical
Язык: Английский
Процитировано
9
ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 15(1), С. 338 - 353
Опубликована: Дек. 29, 2022
Dysregulation of superoxide anion (O2-) and hydrogen peroxide (H2O2) metabolism in the microenvironment rheumatoid arthritis (RA) drives feedback loops TNF-α IL-1β thereby inducing an inflammatory storm between immune cells joint tissue cells. Here, we combine nanoscale manganese dioxide (MnO2) with microvesicles derived from macrophage (MMV). The former possesses dismutase (SOD) catalase (CAT)-like activities that can modulate this imbalance, amplify enzyme-like by using amorphous hollow mesoporous structure surface modification. latter is a natural endogenous component parent cell-like homing ability unique function transmitting information to surrounding distant (″messenger function″), which helps MnO2 (H-MnO2) nanozymes cloak blood reach site inflammation, where they not only accumulate activated macrophages but also pretend be ″messengers″ are utilized fibroblast-like synoviocytes (FLS) chondrocytes. In addition, load dexamethasone sodium phosphate (DSP) for helping work. Messenger nanozyme (MMV-MnO2@DSP) inherits properties MMV mimics enzymatic activity SOD CAT. It accumulates restore O2- H2O2 while promoting repolarization inhibits among macrophages, synoviocytes, chondrocytes, leading anti-rheumatoid effects vitro vivo.
Язык: Английский
Процитировано
36
Pharmaceutics, Год журнала: 2022, Номер 14(3), С. 540 - 540
Опубликована: Фев. 28, 2022
Rheumatoid arthritis (RA) and osteoarthritis (OA) are disabling musculoskeletal disorders that affect joints cartilage may lead to bone degeneration. Conventional delivery of anti-arthritic agents is limited due short intra-articular half-life toxicities. Innovations in polymer chemistry have led advancements hydrogel technology, offering a versatile drug platform exhibiting tissue-like properties with tunable loading high residence time This review discusses the advantages drawbacks polymeric materials along their modifications as well applications for fabricating hydrogels loaded therapeutic (small molecule drugs, immunotherapeutic agents, cells). Emphasis given biological potentialities hybrid systems/micro-and nanotechnology-integrated promising tools. Applications facile tuning loading, maintaining long-term release, consequently improving outcome patient compliance detailed. also suggests advantages, challenges, future perspectives potential alter landscape currently available treatment modalities.
Язык: Английский
Процитировано
33
Pharmaceuticals, Год журнала: 2024, Номер 17(2), С. 248 - 248
Опубликована: Фев. 14, 2024
Disease-modifying anti-rheumatic drugs (DMARDs) is a class of medicines that are frequently prescribed to patients suffering from rheumatoid arthritis (RA). Methotrexate, sulfasalazine, hydroxychloroquine, and azathioprine examples non-biologic DMARDs being used for alleviating pain preventing disease progression. Biologic (bDMARDs) like infliximab, rituximab, etanercept, adalimumab, tocilizumab, certolizumab pegol, abatacept have greater effectiveness with fewer adverse effects in comparison DMARDs. This review article delineates the classification their characteristic attributes. The poor aqueous solubility or permeability causes limited oral bioavailability synthetic DMARDs, while high molecular weights along bulky structures bDMARDs posed few obstacles drug delivery need be addressed through development nanoformulations cubosomes, nanospheres, nanoemulsions, solid lipid nanoparticles, nanomicelles, liposome, niosomes, nanostructured carrier. main focus this highlight potential role nanotechnology increasing solubility, dissolution, improved management RA. also focusses on different aspects nanoparticles applications biologics, biocompatibility, body clearance, scalability, loading, stability issues.
Язык: Английский
Процитировано
6
Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10
Опубликована: Окт. 12, 2022
Rheumatoid Arthritis is a universal disease that severely affects the normal function of human joints and quality life. Millions people around world are diagnosed with rheumatoid arthritis every year, carrying substantial burden for both individual society. Hydrogel polymer material good mechanical properties biocompatibility, which shows great potential in treatment arthritis. With progress tissue engineering biomedical technology recent years, more studies focus on application hydrogels We reviewed applied years. Also, needed comprehensive performance current applications therapeutic based complex pathophysiological characteristics also concluded. Additionally, we proposed challenges difficulties put forward some prospects future research.
Язык: Английский
Процитировано
21