Enhanced pharmacokinetic approach for anastrozole in macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for estrogen-positive breast cancer therapy
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 28
Опубликована: Янв. 3, 2025
Breast
cancer
(BC)
is
a
substantial
reason
for
cancer-related
mortality
among
women
across
the
globe.
Anastrozole
(ANS)
an
effective
orally
administered
hormonal
therapy
estrogen+
(ER+)
BC
treatment.
However,
several
side
effects
and
pharmacokinetic
limitations
restricted
its
uses
in
Therefore,
this
study
developed
Язык: Английский
Midkine as a driver of age-related changes and increase in mammary tumorigenesis
Cancer Cell,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Methods and Models in Mammary Gland Biology and Breast Cancer Research
Journal of Mammary Gland Biology and Neoplasia,
Год журнала:
2025,
Номер
30(1)
Опубликована: Март 8, 2025
The
collection
on
Methods
and
Models
in
Mammary
Gland
Biology
Breast
Cancer
Research
showcases
recent
advances
tools
models
that
enhance
our
understanding
of
mammary
gland
development
breast
cancer.
This
includes
sixteen
articles,
collectively
addressing
approaches
to
investigate
key
aspects
biology
tumorigenesis,
including
hormonal
signaling,
tissue
architecture,
tumor
microenvironment,
species-specific
development.
issue
highlights
innovations
such
as
optimized
progesterone
receptor
reporters,
improved
menopause
models,
3D-printed
epithelial
structures.
It
also
features
advancements
organoid-based
studies,
situ
labeling
proliferation
large
animals,
preclinical
for
cancer
prevention,
high-resolution
imaging
techniques.
Methodologies
studying
macrophage-cancer
cell
interactions
lysosomal
function
are
provided
step-by-step
protocols.
Additionally,
review
articles
provide
insights
into
diverse
mammalian
organoid
systems,
rat
strategies
modeling
metastasis.
Together,
these
contributions
advance
research
by
refining
experimental
approaches,
expanding
model
diversity,
fostering
translational
applications
Язык: Английский
Overexpression of KIF2C amplifies tamoxifen resistance and lung metastasis of breast cancer through PLK1/C-Myc pathway
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Язык: Английский
Rat models of musculoskeletal lysosomal storage disorders and their role in pre-clinical evaluation of gene therapy approaches
Mammalian Genome,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Abstract
Mice
have
been
a
cornerstone
of
biomedical
research
for
decades
studying
wide
range
biological
processes,
disease
mechanisms,
and
the
assessment
therapies.
Moreover,
mice
present
several
practical
advantages
such
as
small
size,
low
cost
ease
genetic
manipulation.
While
offer
numerous
benefits,
certain
areas,
rat
models
provide
closer
representation
human
progression,
offering
better
insights
translational
therapeutic
development.
This
resemblance
is
particularly
important
focusing
on
diseases
involving
cardiovascular
musculoskeletal
system.
In
rats,
pathophysiology
these
mirrors
clinical
alterations
observed
in
humans.
review
focuses
key
phenotypic
differences
between
mouse
lysosomal
storage
disorders
that
specifically
manifest
with
cardiac,
skeletal
muscle,
bone
joint
involvement
(Pompe
Danon
diseases,
Maroteaux-Lamy
Morquio
A
syndromes).
Furthermore,
we
discuss
potential
various
adeno-associated
viral
vector-mediated
gene
therapies
evaluated
models,
highlighting
their
contributions
to
advancing
treatment
options
debilitating
conditions.
Язык: Английский
Quantitative Analysis of Endocrine Disruption by Ketoconazole and Diethylstilbestrol in Rat Mammary Gland Development
Reproductive Toxicology,
Год журнала:
2025,
Номер
unknown, С. 108929 - 108929
Опубликована: Апрель 1, 2025
Язык: Английский
Precision preclinical modeling to advance cancer treatment
JNCI Journal of the National Cancer Institute,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 9, 2024
A
new
era
of
cancer
management
is
underway
in
which
treatments
are
being
developed
for
the
entire
continuum
disease
process.
The
availability
genetically
engineered
and
naturally
occurring
preclinical
models
serve
as
instructive
platforms
evaluating
therapeutic
mechanisms.
However,
a
major
clinical
challenge
that
malignancy
process
occurs
across
multiple
scales
including
genetic
mutations,
malignant
changes
cell
behavior,
dysregulated
tumor
microenvironments,
systemic
adaptations
host.
multi-disciplinary
group
investigators
coalesced
at
National
Cancer
Institute
Oncology
Models
Forum
(NCI-OMF)
with
overall
goal
to
provide
updates
on
use
precision
cancer.
benefits
limitations
were
discussed
order
identify
strategies
maximizing
opportunities
modeling
could
inform
future
prevention
treatment
approaches.
Our
shared
perspective
single
cell,
multi-cell,
organoid,
situ
remarkable
resources
challenges
ahead.
We
roadmap
parsing
already
available
include
preliminary
recommendations
application
next
generation
intervention.
Язык: Английский