Precision preclinical modeling to advance cancer treatment DOI Creative Commons
David H. Gutmann, Jesse S. Boehm, Elinor K. Karlsson

et al.

JNCI Journal of the National Cancer Institute, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

A new era of cancer management is underway in which treatments are being developed for the entire continuum disease process. The availability genetically engineered and naturally occurring preclinical models serve as instructive platforms evaluating therapeutic mechanisms. However, a major clinical challenge that malignancy process occurs across multiple scales including genetic mutations, malignant changes cell behavior, dysregulated tumor microenvironments, systemic adaptations host. multi-disciplinary group investigators coalesced at National Cancer Institute Oncology Models Forum (NCI-OMF) with overall goal to provide updates on use precision cancer. benefits limitations were discussed order identify strategies maximizing opportunities modeling could inform future prevention treatment approaches. Our shared perspective single cell, multi-cell, organoid, situ remarkable resources challenges ahead. We roadmap parsing already available include preliminary recommendations application next generation intervention.

Language: Английский

Enhanced pharmacokinetic approach for anastrozole in macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for estrogen-positive breast cancer therapy DOI
Arfa Nasrine, Sourav Mohanto,

Soumya Narayana

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Jan. 3, 2025

Breast cancer (BC) is a substantial reason for cancer-related mortality among women across the globe. Anastrozole (ANS) an effective orally administered hormonal therapy estrogen+ (ER+) BC treatment. However, several side effects and pharmacokinetic limitations restricted its uses in Therefore, this study developed

Language: Английский

Citations

1
Midkine as a driver of age-related changes and increase in mammary tumorigenesis DOI Creative Commons
Pengze Yan, Ernesto Rojas Jiménez, Zheqi Li

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

6
Methods and Models in Mammary Gland Biology and Breast Cancer Research DOI Creative Commons
Johanna I. Englund, Zuzana Koledová

Journal of Mammary Gland Biology and Neoplasia, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 8, 2025

The collection on Methods and Models in Mammary Gland Biology Breast Cancer Research showcases recent advances tools models that enhance our understanding of mammary gland development breast cancer. This includes sixteen articles, collectively addressing approaches to investigate key aspects biology tumorigenesis, including hormonal signaling, tissue architecture, tumor microenvironment, species-specific development. issue highlights innovations such as optimized progesterone receptor reporters, improved menopause models, 3D-printed epithelial structures. It also features advancements organoid-based studies, situ labeling proliferation large animals, preclinical for cancer prevention, high-resolution imaging techniques. Methodologies studying macrophage-cancer cell interactions lysosomal function are provided step-by-step protocols. Additionally, review articles provide insights into diverse mammalian organoid systems, rat strategies modeling metastasis. Together, these contributions advance research by refining experimental approaches, expanding model diversity, fostering translational applications

Language: Английский

Citations

0
Overexpression of KIF2C amplifies tamoxifen resistance and lung metastasis of breast cancer through PLK1/C-Myc pathway DOI
Rui Tian,

Jilin Kong,

Hongyan Zang

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
Rat models of musculoskeletal lysosomal storage disorders and their role in pre-clinical evaluation of gene therapy approaches DOI Creative Commons
Sara Marcó, Sergio Muñoz, Fàtima Bosch

et al.

Mammalian Genome, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Mice have been a cornerstone of biomedical research for decades studying wide range biological processes, disease mechanisms, and the assessment therapies. Moreover, mice present several practical advantages such as small size, low cost ease genetic manipulation. While offer numerous benefits, certain areas, rat models provide closer representation human progression, offering better insights translational therapeutic development. This resemblance is particularly important focusing on diseases involving cardiovascular musculoskeletal system. In rats, pathophysiology these mirrors clinical alterations observed in humans. review focuses key phenotypic differences between mouse lysosomal storage disorders that specifically manifest with cardiac, skeletal muscle, bone joint involvement (Pompe Danon diseases, Maroteaux-Lamy Morquio A syndromes). Furthermore, we discuss potential various adeno-associated viral vector-mediated gene therapies evaluated models, highlighting their contributions to advancing treatment options debilitating conditions.

Language: Английский

Citations

0
Quantitative Analysis of Endocrine Disruption by Ketoconazole and Diethylstilbestrol in Rat Mammary Gland Development DOI
Maël Montévil, Cheryl M. Schaeberle, Julie Boberg

et al.

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108929 - 108929

Published: April 1, 2025

Language: Английский

Citations

0
Precision preclinical modeling to advance cancer treatment DOI Creative Commons
David H. Gutmann, Jesse S. Boehm, Elinor K. Karlsson

et al.

JNCI Journal of the National Cancer Institute, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

A new era of cancer management is underway in which treatments are being developed for the entire continuum disease process. The availability genetically engineered and naturally occurring preclinical models serve as instructive platforms evaluating therapeutic mechanisms. However, a major clinical challenge that malignancy process occurs across multiple scales including genetic mutations, malignant changes cell behavior, dysregulated tumor microenvironments, systemic adaptations host. multi-disciplinary group investigators coalesced at National Cancer Institute Oncology Models Forum (NCI-OMF) with overall goal to provide updates on use precision cancer. benefits limitations were discussed order identify strategies maximizing opportunities modeling could inform future prevention treatment approaches. Our shared perspective single cell, multi-cell, organoid, situ remarkable resources challenges ahead. We roadmap parsing already available include preliminary recommendations application next generation intervention.

Language: Английский

Citations

1