Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 1, 2024
Aberrant
glycosylation
patterns
of
glycoproteins
and
glycolipids
have
long
been
recognized
as
one
the
major
hallmarks
cancer
cells
that
has
led
to
numerous
glycoconjugate
vaccine
attempts.
These
abnormal
profiles
mostly
originate
from
lack
key
glycosyltransferases
activities,
mutations,
over
expressions,
or
modifications
requisite
chaperone
for
functional
folding.
Due
their
relative
structural
simplicity,
O
-linked
glycans
altered
mucin
family
particularly
attractive
in
design
tumor
associated
carbohydrate-based
vaccines.
Several
such
formulations
generated
potent
monoclonal
anti-carbohydrate
antibodies
useful
diagnostic
immunotherapies
fight
against
cancer.
Paradoxically,
related
enveloped
viruses
also
express
analogous
N
-
patterns.
However,
due
fact
are
not
equipped
with
appropriate
glycosyl
enzyme
machinery,
they
need
hijack
infected
host
cells.
Although
resulting
very
similar
those
normal
cells,
some
glycan
often
share
common
simplicity
identified
on
Consequently,
given
both
viral
glycoepitopes,
vaccines
could
be
highly
generate
immune
responses
target
conditions.
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Май 15, 2023
Coronavirus
disease
2019
(COVID-19)
is
caused
by
a
new
member
of
the
Coronaviridae
family
known
as
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
There
are
structural
and
non-structural
proteins
(NSPs)
in
genome
this
virus.
S,
M,
H,
E
proteins,
NSPs
include
accessory
replicase
proteins.
The
NSP
components
SARS-CoV-2
play
an
important
role
its
infectivity,
some
them
may
be
pathogenesis
chronic
diseases,
including
cancer,
coagulation
disorders,
neurodegenerative
cardiovascular
diseases.
interact
with
targets
such
angiotensin-converting
enzyme
(ACE2)
receptor.
In
addition,
can
stimulate
pathological
intracellular
signaling
pathways
triggering
transcription
factor
hypoxia-inducible
factor-1
(HIF-1),
neuropilin-1
(NRP-1),
CD147,
Eph
receptors,
which
roles
progression
diseases
like
Alzheimer's
disease,
epilepsy,
multiple
sclerosis,
cancers
glioblastoma,
lung
malignancies,
leukemias.
Several
compounds
polyphenols,
doxazosin,
baricitinib,
ruxolitinib
could
inhibit
these
interactions.
It
has
been
demonstrated
that
spike
protein
stronger
affinity
for
human
ACE2
than
SARS-CoV,
leading
current
study
to
hypothesize
newly
produced
variant
Omicron
receptor-binding
domain
(RBD)
binds
more
strongly
primary
strain.
SARS
Middle
East
(MERS)
viruses
against
have
become
resistant
previous
vaccines.
Therefore,
review
recent
studies
performance
vaccines
their
effects
on
COVID-19
related
vital
need
deal
conditions.
This
examines
potential
initiation
it
anticipated
serve
effective
vaccine
or
treatment
Video
Abstract.
Cellular & Molecular Biology Letters,
Год журнала:
2022,
Номер
27(1)
Опубликована: Май 13, 2022
Abstract
In
nature,
lectins
are
widely
dispersed
proteins
that
selectively
recognize
and
bind
to
carbohydrates
glycoconjugates
via
reversible
bonds
at
specific
binding
sites.
Many
viral
diseases
have
been
treated
with
due
their
wide
range
of
structures,
specificity
for
carbohydrates,
ability
carbohydrates.
Through
hemagglutination
assays,
these
can
be
detected
interacting
various
on
the
surface
cells
envelopes.
This
review
discusses
most
robust
rationally
engineered
versions,
such
as
lectibodies,
antiviral
proteins.
Fusion
lectin
antibody’s
crystallizable
fragment
(Fc)
immunoglobulin
G
(IgG)
produces
a
molecule
called
“lectibody”
act
carbohydrate-targeting
antibody.
Lectibodies
not
only
glycoproteins
neutralize
clear
viruses
or
infected
by
but
also
perform
Fc-mediated
antibody
effector
functions.
These
functions
include
complement-dependent
cytotoxicity
(CDC),
antibody-dependent
cell-mediated
(ADCC),
phagocytosis
(ADCP).
addition
entering
host
cells,
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
spike
protein
S1
binds
angiotensin-converting
enzyme
(ACE2)
downregulates
it
type
I
interferons
in
way
may
lead
lung
disease.
The
SARS-CoV-2
human
immunodeficiency
virus
(HIV)
envelope
heavily
glycosylated,
which
could
make
them
major
target
developing
vaccines,
diagnostic
tests,
therapeutic
drugs.
neutralization
clearance
glycans
located
(e.g.,
glycosylated
protein).
International Journal of Food Science,
Год журнала:
2023,
Номер
2023, С. 1 - 16
Опубликована: Апрель 27, 2023
Some
plant
foods
evolve
defense
mechanisms
to
protect
themselves
from
predators
by
producing
inherent
chemicals
as
secondary
metabolites
such
cyanogenic
glycosides,
glycoalkaloids,
glucosinolates,
pyrrolizidine
alkaloids,
and
lectins.
These
are
beneficial
for
the
itself
but
toxic
other
organisms,
including
human
beings.
of
these
believed
have
therapeutic
benefits
therefore
used
against
chronic
health
complications
cancer.
Inversely,
short-
long-term
exposure
significant
amounts
phytotoxins
may
end
up
with
irreversible
negative
problems
in
important
organ
systems,
severe
cases,
they
can
be
carcinogenic
fatal.
A
systematic
literature
search
relevant
published
articles
indexed
Google
Scholar®,
PubMed®,
Scopus®,
Springer
Link®,
Web
Science®,
MDPI®,
ScienceDirect
databases
was
obtain
necessary
information.
Various
traditional
emerging
food-processing
techniques
been
found
considerably
reduce
most
toxicants
food
their
safest
level.
Despite
ability
preserve
nutritional
value
processed
foods,
processing
methods
limited
application
accessibility
middle-
low-income
countries.
As
a
consequence,
much
more
work
is
recommended
on
implementation
technologies,
additional
scientific
that
effective
naturally
occurring
toxicants,
particularly
alkaloids.
Cells,
Год журнала:
2021,
Номер
10(7), С. 1619 - 1619
Опубликована: Июнь 28, 2021
Betacoronaviruses,
responsible
for
the
“Severe
Acute
Respiratory
Syndrome”
(SARS)
and
“Middle
East
(MERS),
use
spikes
protruding
from
virion
envelope
to
attach
subsequently
infect
host
cells.
The
coronavirus
spike
(S)
proteins
contain
receptor
binding
domains
(RBD),
allowing
specific
recognition
of
either
dipeptidyl
peptidase
CD23
(MERS-CoV)
or
angiotensin-converting
enzyme
ACE2
(SARS-Cov,
SARS-CoV-2)
cell
receptors.
heavily
glycosylated
S
protein
includes
both
complex
high-mannose
type
N-glycans
that
are
well
exposed
at
surface
spikes.
A
detailed
analysis
carbohydrate-binding
specificity
mannose-binding
lectins
plants,
algae,
fungi,
bacteria,
revealed
that,
depending
on
their
origin,
they
preferentially
recognize
N-glycans,
N-glycans.
Since
glycans
substantially
decorate
proteins,
mannose-specific
potentially
useful
glycan
probes
targeting
SARS-CoV,
MERS-CoV,
SARS-CoV-2
virions.
Mannose-binding
legume
lectins,
like
pea
lectin,
monocot
snowdrop
lectin
algal
griffithsin,
which
specifically
glycans,
respectively,
particularly
adapted
coronaviruses.
biomedical
prospects
coronaviruses
with
wide-ranging
including
detection,
immobilization,
prevention,
control
infection.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Июнь 7, 2023
The
purpose
of
this
study
was
to
evaluate
available
evidence
on
the
association
between
human
oral
microbiota
and
coronavirus
disease
2019
(COVID-19)
summarize
relevant
data
obtained
during
pandemic.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Март 17, 2023
The
hallmark
of
acute
respiratory
distress
syndrome
(ARDS)
pathobiology
is
unchecked
inflammation-driven
diffuse
alveolar
damage
and
alveolar-capillary
barrier
dysfunction.
Currently,
therapeutic
interventions
for
ARDS
remain
largely
limited
to
pulmonary-supportive
strategies,
there
an
unmet
demand
pharmacologic
therapies
targeting
the
underlying
pathology
in
patients
suffering
from
illness.
complement
cascade
(ComC)
plays
integral
role
regulation
both
innate
adaptive
immune
responses.
ComC
activation
can
prime
overzealous
cytokine
storm
tissue/organ
damage.
lung
injury
(ALI)
have
established
relationship
with
early
maladaptive
activation.
In
this
review,
we
collected
evidence
current
studies
linking
ALI/ARDS
dysregulation,
focusing
on
elucidating
new
emerging
roles
extracellular
(canonical)
intracellular
(non-canonical
or
complosome),
(complementome)
pathobiology,
highlighting
complementome
as
a
vital
nexus
pathobiological
connectome
via
its
crosstalking
other
systems
immunome,
DAMPome,
PAMPome,
coagulome,
metabolome,
microbiome.
We
also
discussed
diagnostic/therapeutic
potential
future
direction
care
ultimate
goal
better
defining
mechanistic
subtypes
(endotypes
theratypes)
through
methodologies
order
facilitate
more
precise
effective
complement-targeted
therapy
treating
these
comorbidities.
This
information
leads
support
anti-inflammatory
strategy
by
ComC,
where
arsenal
clinical-stage
complement-specific
drugs
available,
especially
due
COVID-19.
