Toxicology, Год журнала: 2024, Номер 506, С. 153866 - 153866
Опубликована: Июнь 21, 2024
Язык: Английский
BioMetals, Год журнала: 2024, Номер 37(4), С. 803 - 817
Опубликована: Фев. 12, 2024
Abstract The majority of the so-called heavy metals are suspected to be involved in a number pathologies and play role human carcinogenesis. Some them (i.e. arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg) nickel (Ni)) have been defined as carcinogens, increasing susceptibility tumor development progression humans. Moreover, Ni, Cr, Cd, Hg, Pb together with zinc (Zn) iron (Fe), may capable stimulating breast cancer reducing patient’s sensitivity treatment through alterations DNA methylation. In patients gastric cancers, levels various augmented hypothesized amplify expression epidermal growth factor receptor type 2 gene. Cd increase risk lung negative impact on overall survival patients. To investigate relation between biological samples risk, occurrence individuals, comprehensive review work was performed, focus breast, lung, prostate cancers. An extensive search strategy devised ensure relevant literature could identified, PECO framework being adopted facilitate this identify key terms. As evidenced review, there is substantial data support hypothesis that influence progression. Unluckily papers dealing determination directly from tissues still rather limited, so we decided expand scope also analyses carried out other samples, urine, plasma, hair, nail, etc. studies reviewed showed several limitations current knowledge gaps present require further investigation improve our comprehension different tumorigenesis. Graphical abstract
Язык: Английский
Процитировано
30
Applied Sciences, Год журнала: 2023, Номер 13(13), С. 7724 - 7724
Опубликована: Июнь 29, 2023
The beneficial nutrients and biologically active ingredients extracted from plants have received great attention in the prevention treatment of several diseases, including hypercholesterolemic, cancer, diabetes, cardiovascular disorders, hypoglycemic, hypolipidemic, edema, joint pain, weight control, eye vision problems, neuroprotective effects, asthma. Highly predominantly exist fruit cladodes, known as phytochemicals (rich contents minerals, betalains, carbohydrates, vitamins, antioxidants, polyphenols, taurine), which are renowned for their properties relation to human health. Polyphenols widely present demonstrated pharmacological ability through antimicrobial, anti-inflammatory, anti-bacterial, antioxidant capacity, multi-role act Opuntia ficus indica makes it suitable current future usage cosmetics moisturizing, skin improvement, wound care, healthful food essential amino acids, macro micro elements body growth, building materials an eco-friendly sustainable material, a bio-composite, insulator. However, more comprehensive understanding extensive research on diverse array phytochemical cactus pear needed. This review therefore aims gather discuss existing literature chemical composition potential applications extracts, well highlight promising directions this valuable plant.
Язык: Английский
Процитировано
26
Metabolites, Год журнала: 2023, Номер 13(10), С. 1048 - 1048
Опубликована: Окт. 2, 2023
Trace metal elements are of vital importance for fundamental biological processes. They function in various metabolic pathways after the long evolution living organisms. Glucose is considered to be one main sources energy that supports activities, and its metabolism tightly regulated by trace such as iron, zinc, copper, manganese. However, there still a lack understanding regulation glucose elements. In particular, underlying mechanism action remains elucidated. this review, we summarize current concepts progress linking metabolism, particularly manganese, iron.
Язык: Английский
Процитировано
25
Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер 416(11), С. 2641 - 2656
Опубликована: Янв. 20, 2024
Язык: Английский
Процитировано
11
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 5, 2025
Abstract The significance of biomedical applications Ti alloys is best emphasized by their widespread utilization as implantable materials, such internal supports and bone replacements. are sensitive to fretting wear, which leads the early failure implants. Improved wear resistance implants essential ensure a prolonged implant life. Based on structure‐function‐integrated concept, this work unprecedentedly designs fabricates an antibacterial 8SiC/Ti‐3Cu composite with improved using microwave sintering from pure Ti, Cu, nano‐SiC powders. For comparison, SiC‐free Ti‐3Cu manufactured under same conditions sintering. addition 8 vol.% SiC significantly reduces porosity pore size composites. shows Vickers hardness 353 HV, compressive strength 803 MPa, elastic modulus 28.7 GPa, increased (wear rate decreased 70% compared Ti‐3Cu). In addition, exhibits excellent electrochemical corrosion resistance, biocompatibility in relation MC3T3‐E1 cells, bacteriostatic over 99% against E. coli . combination wear‐resistant nano‐reinforced 2 Cu renders it highly promising material.
Язык: Английский
Процитировано
2
BMC Plant Biology, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 28, 2025
Abstract Selenium is a beneficial element in agriculture, particularly for its potential to improve plant growth and stress tolerance at suitable concentrations. In this study, Phaseolus vulgaris was foliar-sprayed with selenium selenate (Se) or nanoparticles (SeNP) different concentrations during the vegetative stage; afterward, seed yield analyzed metabolomics using 1 H, J -resolved HSQC NMR data, databases. A total of 47 metabolites were identified sugars being major chemical class. control sample, most abundant sugar stachyose (14.6 ± 0.8 mM). Among alkaloids, concentration trigonelline highest (0.6 0.08 Chemometric cluster analyses distinctly differentiated from Se SeNP-treated samples. Treatments SeNP resulted elevated sugars, carboxylic acids, sulfur-containing amino acids compared treated Conversely, betaine levels higher The presence significantly decreased several aliphatic e.g. alanine. addition 50 µM upregulated syringate by 2-fold 1.75-fold, respectively, relative control. Pathway analysis indicated altered pathways due arginine biosynthesis nitrogen metabolism. influenced glyoxylate dicarboxylate metabolism as well glycine-serine threonine This study proved that are more efficient than enhancing metabolic profile which will have implications agricultural practices, focusing on sustainability nutritional enhancement crops.
Язык: Английский
Процитировано
1
OpenNano, Год журнала: 2023, Номер 14, С. 100188 - 100188
Опубликована: Сен. 13, 2023
The Strobilanthes cordifolia plant, a member of the Acanthaceae family, has been extensively studied due to its wide range biological properties. This particular research focused on green synthesis FeNPs/CuNPs and evaluated effectiveness experiment through various characterization techniques, including UV, FTIR, XRD, SEM with EDAX. UV analysis provided valuable insights, showing that synthesized nanoparticles had highest absorption values at 462nm for FeNPs 438nm CuNPs. FTIR confirmed presence different functional groups, while XRD measurements validated their crystalline nature. data revealed diverse shapes nanoparticles, rods spherical shapes. Additionally, EDAX Fe Cu elements in biosynthesized nanoparticles. antibacterial activity CuNPs against Staphylococcus aureus Escherichia coli showed significant inhibition. Moreover, demonstrated strong antioxidant activity, as evidenced by effective inhibition DPPH ABTS assays. Their potential anti-diabetic agents was also explored, assessments inhibitory effects α-Amylase α-Glucosidase enzymes. displayed anti-cholinergic enzymes such AChE BChE. Furthermore, comprehensive toxicological studies higher level mosquito larvicidal Aedes aegypti, Anopheles stephensi, Culex quinquefasciatus. Among these, exhibited larval mortality rate 95% Cx. Quinquefasciatus, 93%. In conclusion, this study possess favorable characteristics biomedical applications.
Язык: Английский
Процитировано
22
Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2023, Номер 2(2), С. 35 - 43
Опубликована: Апрель 8, 2023
Zinc is a crucial micronutrient found in food that essential for the development of all living organisms, it plays vital role gene expression and various physical processes, its deficiency can lead to disease onset reduce crop yield, restrict plant development, lower quality produced goods, zinc also used fertilizers handling metals protect them from oxidation. Additionally, important enhancing human immune system, result hair loss, memory skin disorders, muscular weakness.
Язык: Английский
Процитировано
18
Chemistry Africa, Год журнала: 2024, Номер 7(7), С. 3605 - 3618
Опубликована: Июнь 26, 2024
Язык: Английский
Процитировано
7
Biosensors, Год журнала: 2025, Номер 15(1), С. 41 - 41
Опубликована: Янв. 13, 2025
In recent years, environmental and food safety have garnered substantial focus due to their intimate connection with human health. Numerous biosensors been developed for identifying deleterious compounds; however, these reveal certain limitations. Nanopore sensors, featuring nano-scaled pore size, demonstrated outstanding performance in terms of rapidity, sensitivity, selectivity as a single-molecule technique surveillance. this review, we present comprehensive overview nanopore applications two fields. To elucidate the pioneering roles nanopores, analytes are categorized into three distinct groups, including metal ions, synthetic contaminants, biotoxins. Moreover, variety strategies involved, such coalescence ligand probes, implementation chemical reactions, functionalization etc. These scientific studies showcase versatility diversity technique, paving way further developments technology safety.
Язык: Английский
Процитировано
1