Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(2)
Опубликована: Янв. 19, 2025
ABSTRACT
In
the
search
of
antiplasmodium
agents,
hydrazone
ligands,
that
is,
(2‐hydroxy‐5‐nitrobenzylidene)benzo[b]thiophene‐2‐carbohydrazone
(H
2
L
1
)
/(3,5‐dichloro‐2‐hydroxybenzylidene)benzo[b]thiophene‐2‐carbohydrazone
and
their
Co(II),
Ni(II),
Cu(II),
Zn(II)
metal
complexes
were
synthesized.
All
compounds
well
characterized
by
wide
range
spectral
physical
techniques,
FT‐IR,
H
NMR,
13
C
ESR,
mass
spectrometry,
UV‐Vis,
XRD,
SEM‐EDAX,
molecular
conductivity,
thermal
studies
(TG‐DTA).
The
coordination
O‐phenolic,
O‐enolic,
N‐azomethine
donor
atoms
three
aqua
ligands
to
metal(II)
ions
was
confirmed
various
physicochemical
affirming
octahedral
geometry
complexes.
Biological
evaluation
synthesized
involved
assessing
potency
utilizing
microassay
antimicrobial
activities
using
serial
dilution
technique.
Cu(II)
(
5
,
6
9
10
significantly
inhibited
growth
parasitic
ailments
caused
Plasmodium
falciparum
3D7
strain
also
exhibited
remarkable
effectiveness
against
diseases
microbes
comparable
with
standard
drugs
(ciprofloxacin
fluconazole).
Moreover,
theoretical
study
including
docking
employed
3,5‐dihydroxy‐2‐naphthoic
acid
PDB:1U5A
P.
protein
receptor
validate
most
potent
ligand
3
–
).
This
analysis
indicated
docked
could
serve
as
a
promising
drug
candidate
for
malaria.
whereas
ADMET
profiling
authenticated
drug‐like
features
.
Thus,
this
research
provides
fresh
perspectives
in
vivo
minor
developments.
BioMetals,
Год журнала:
2024,
Номер
37(4), С. 803 - 817
Опубликована: Фев. 12, 2024
Abstract
The
majority
of
the
so-called
heavy
metals
are
suspected
to
be
involved
in
a
number
pathologies
and
play
role
human
carcinogenesis.
Some
them
(i.e.
arsenic
(As),
cadmium
(Cd),
chromium
(Cr),
lead
(Pb),
mercury
(Hg)
nickel
(Ni))
have
been
defined
as
carcinogens,
increasing
susceptibility
tumor
development
progression
humans.
Moreover,
Ni,
Cr,
Cd,
Hg,
Pb
together
with
zinc
(Zn)
iron
(Fe),
may
capable
stimulating
breast
cancer
reducing
patient’s
sensitivity
treatment
through
alterations
DNA
methylation.
In
patients
gastric
cancers,
levels
various
augmented
hypothesized
amplify
expression
epidermal
growth
factor
receptor
type
2
gene.
Cd
increase
risk
lung
negative
impact
on
overall
survival
patients.
To
investigate
relation
between
biological
samples
risk,
occurrence
individuals,
comprehensive
review
work
was
performed,
focus
breast,
lung,
prostate
cancers.
An
extensive
search
strategy
devised
ensure
relevant
literature
could
identified,
PECO
framework
being
adopted
facilitate
this
identify
key
terms.
As
evidenced
review,
there
is
substantial
data
support
hypothesis
that
influence
progression.
Unluckily
papers
dealing
determination
directly
from
tissues
still
rather
limited,
so
we
decided
expand
scope
also
analyses
carried
out
other
samples,
urine,
plasma,
hair,
nail,
etc.
studies
reviewed
showed
several
limitations
current
knowledge
gaps
present
require
further
investigation
improve
our
comprehension
different
tumorigenesis.
Graphical
abstract
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 5, 2025
Abstract
The
significance
of
biomedical
applications
Ti
alloys
is
best
emphasized
by
their
widespread
utilization
as
implantable
materials,
such
internal
supports
and
bone
replacements.
are
sensitive
to
fretting
wear,
which
leads
the
early
failure
implants.
Improved
wear
resistance
implants
essential
ensure
a
prolonged
implant
life.
Based
on
structure‐function‐integrated
concept,
this
work
unprecedentedly
designs
fabricates
an
antibacterial
8SiC/Ti‐3Cu
composite
with
improved
using
microwave
sintering
from
pure
Ti,
Cu,
nano‐SiC
powders.
For
comparison,
SiC‐free
Ti‐3Cu
manufactured
under
same
conditions
sintering.
addition
8
vol.%
SiC
significantly
reduces
porosity
pore
size
composites.
shows
Vickers
hardness
353
HV,
compressive
strength
803
MPa,
elastic
modulus
28.7
GPa,
increased
(wear
rate
decreased
70%
compared
Ti‐3Cu).
In
addition,
exhibits
excellent
electrochemical
corrosion
resistance,
biocompatibility
in
relation
MC3T3‐E1
cells,
bacteriostatic
over
99%
against
E.
coli
.
combination
wear‐resistant
nano‐reinforced
2
Cu
renders
it
highly
promising
material.
Applied Sciences,
Год журнала:
2023,
Номер
13(13), С. 7724 - 7724
Опубликована: Июнь 29, 2023
The
beneficial
nutrients
and
biologically
active
ingredients
extracted
from
plants
have
received
great
attention
in
the
prevention
treatment
of
several
diseases,
including
hypercholesterolemic,
cancer,
diabetes,
cardiovascular
disorders,
hypoglycemic,
hypolipidemic,
edema,
joint
pain,
weight
control,
eye
vision
problems,
neuroprotective
effects,
asthma.
Highly
predominantly
exist
fruit
cladodes,
known
as
phytochemicals
(rich
contents
minerals,
betalains,
carbohydrates,
vitamins,
antioxidants,
polyphenols,
taurine),
which
are
renowned
for
their
properties
relation
to
human
health.
Polyphenols
widely
present
demonstrated
pharmacological
ability
through
antimicrobial,
anti-inflammatory,
anti-bacterial,
antioxidant
capacity,
multi-role
act
Opuntia
ficus
indica
makes
it
suitable
current
future
usage
cosmetics
moisturizing,
skin
improvement,
wound
care,
healthful
food
essential
amino
acids,
macro
micro
elements
body
growth,
building
materials
an
eco-friendly
sustainable
material,
a
bio-composite,
insulator.
However,
more
comprehensive
understanding
extensive
research
on
diverse
array
phytochemical
cactus
pear
needed.
This
review
therefore
aims
gather
discuss
existing
literature
chemical
composition
potential
applications
extracts,
well
highlight
promising
directions
this
valuable
plant.
Biosensors,
Год журнала:
2025,
Номер
15(1), С. 41 - 41
Опубликована: Янв. 13, 2025
In
recent
years,
environmental
and
food
safety
have
garnered
substantial
focus
due
to
their
intimate
connection
with
human
health.
Numerous
biosensors
been
developed
for
identifying
deleterious
compounds;
however,
these
reveal
certain
limitations.
Nanopore
sensors,
featuring
nano-scaled
pore
size,
demonstrated
outstanding
performance
in
terms
of
rapidity,
sensitivity,
selectivity
as
a
single-molecule
technique
surveillance.
this
review,
we
present
comprehensive
overview
nanopore
applications
two
fields.
To
elucidate
the
pioneering
roles
nanopores,
analytes
are
categorized
into
three
distinct
groups,
including
metal
ions,
synthetic
contaminants,
biotoxins.
Moreover,
variety
strategies
involved,
such
coalescence
ligand
probes,
implementation
chemical
reactions,
functionalization
etc.
These
scientific
studies
showcase
versatility
diversity
technique,
paving
way
further
developments
technology
safety.
Abstract
Selenium
is
a
beneficial
element
in
agriculture,
particularly
for
its
potential
to
improve
plant
growth
and
stress
tolerance
at
suitable
concentrations.
In
this
study,
Phaseolus
vulgaris
was
foliar-sprayed
with
selenium
selenate
(Se)
or
nanoparticles
(SeNP)
different
concentrations
during
the
vegetative
stage;
afterward,
seed
yield
analyzed
metabolomics
using
1
H,
J
-resolved
HSQC
NMR
data,
databases.
A
total
of
47
metabolites
were
identified
sugars
being
major
chemical
class.
control
sample,
most
abundant
sugar
stachyose
(14.6
±
0.8
mM).
Among
alkaloids,
concentration
trigonelline
highest
(0.6
0.08
Chemometric
cluster
analyses
distinctly
differentiated
from
Se
SeNP-treated
samples.
Treatments
SeNP
resulted
elevated
sugars,
carboxylic
acids,
sulfur-containing
amino
acids
compared
treated
Conversely,
betaine
levels
higher
The
presence
significantly
decreased
several
aliphatic
e.g.
alanine.
addition
50
µM
upregulated
syringate
by
2-fold
1.75-fold,
respectively,
relative
control.
Pathway
analysis
indicated
altered
pathways
due
arginine
biosynthesis
nitrogen
metabolism.
influenced
glyoxylate
dicarboxylate
metabolism
as
well
glycine-serine
threonine
This
study
proved
that
are
more
efficient
than
enhancing
metabolic
profile
which
will
have
implications
agricultural
practices,
focusing
on
sustainability
nutritional
enhancement
crops.
OpenNano,
Год журнала:
2023,
Номер
14, С. 100188 - 100188
Опубликована: Сен. 13, 2023
The
Strobilanthes
cordifolia
plant,
a
member
of
the
Acanthaceae
family,
has
been
extensively
studied
due
to
its
wide
range
biological
properties.
This
particular
research
focused
on
green
synthesis
FeNPs/CuNPs
and
evaluated
effectiveness
experiment
through
various
characterization
techniques,
including
UV,
FTIR,
XRD,
SEM
with
EDAX.
UV
analysis
provided
valuable
insights,
showing
that
synthesized
nanoparticles
had
highest
absorption
values
at
462nm
for
FeNPs
438nm
CuNPs.
FTIR
confirmed
presence
different
functional
groups,
while
XRD
measurements
validated
their
crystalline
nature.
data
revealed
diverse
shapes
nanoparticles,
rods
spherical
shapes.
Additionally,
EDAX
Fe
Cu
elements
in
biosynthesized
nanoparticles.
antibacterial
activity
CuNPs
against
Staphylococcus
aureus
Escherichia
coli
showed
significant
inhibition.
Moreover,
demonstrated
strong
antioxidant
activity,
as
evidenced
by
effective
inhibition
DPPH
ABTS
assays.
Their
potential
anti-diabetic
agents
was
also
explored,
assessments
inhibitory
effects
α-Amylase
α-Glucosidase
enzymes.
displayed
anti-cholinergic
enzymes
such
AChE
BChE.
Furthermore,
comprehensive
toxicological
studies
higher
level
mosquito
larvicidal
Aedes
aegypti,
Anopheles
stephensi,
Culex
quinquefasciatus.
Among
these,
exhibited
larval
mortality
rate
95%
Cx.
Quinquefasciatus,
93%.
In
conclusion,
this
study
possess
favorable
characteristics
biomedical
applications.
Metabolites,
Год журнала:
2023,
Номер
13(10), С. 1048 - 1048
Опубликована: Окт. 2, 2023
Trace
metal
elements
are
of
vital
importance
for
fundamental
biological
processes.
They
function
in
various
metabolic
pathways
after
the
long
evolution
living
organisms.
Glucose
is
considered
to
be
one
main
sources
energy
that
supports
activities,
and
its
metabolism
tightly
regulated
by
trace
such
as
iron,
zinc,
copper,
manganese.
However,
there
still
a
lack
understanding
regulation
glucose
elements.
In
particular,
underlying
mechanism
action
remains
elucidated.
this
review,
we
summarize
current
concepts
progress
linking
metabolism,
particularly
manganese,
iron.
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2023,
Номер
2(2), С. 35 - 43
Опубликована: Апрель 8, 2023
Zinc
is
a
crucial
micronutrient
found
in
food
that
essential
for
the
development
of
all
living
organisms,
it
plays
vital
role
gene
expression
and
various
physical
processes,
its
deficiency
can
lead
to
disease
onset
reduce
crop
yield,
restrict
plant
development,
lower
quality
produced
goods,
zinc
also
used
fertilizers
handling
metals
protect
them
from
oxidation.
Additionally,
important
enhancing
human
immune
system,
result
hair
loss,
memory
skin
disorders,
muscular
weakness.
