New insights into mitochondrial quality control in anthracycline-induced cardiotoxicity: molecular mechanisms, therapeutic targets, and natural products DOI Creative Commons
Weili Li, Yuqin Zhang, Wei Yan

и другие.

International Journal of Biological Sciences, Год журнала: 2024, Номер 21(2), С. 507 - 523

Опубликована: Дек. 31, 2024

Anthracyclines (ANTs) are widely used in cancer therapy, particularly for lymphoma, sarcoma, breast cancer, and childhood leukemia, have become the cornerstone of chemotherapy various malignancies.However, it is associated with fatal dose-dependent cardiovascular complications, especially cardiotoxicity.Mitochondrial quality control mechanisms, encompassing mitophagy, mitochondrial dynamics, biogenesis, maintain homeostasis system.Recent studies highlighted that mechanisms play considerable roles ANTs-induced cardiotoxicity (AIC).In addition, natural products targeting emerged as potential therapeutic strategies to alleviate AIC.This review summarizes types, incidence, prevention, treatment, pathomechanism AIC, delves into molecular pathogenesis explores target these so provide targets drugs address clinical challenges AIC prevention where no effective medicines available.

Язык: Английский

MiR-21-3p inhibitor exerts myocardial protective effects by altering macrophage polarization state and reducing excessive mitophagy DOI Creative Commons
Yujing Huang,

Ya-Lin Huang,

Zhaoling Cai

и другие.

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Окт. 22, 2024

Chronic heart failure (CHF) is closely associated with inflammation and mitochondrial dysfunction in cardiomyocytes. This study attempts to investigate the effects of microRNA-21-3p (miR-21-3p) on macrophage polarization mitophagy CHF. Here we found miR-21-3p was upregulated CHF negatively correlated carnitine palmitoyl transferase 1A (CPT1A). L-palmitoyl (L-PC) exacerbated isoproterenol (ISO)-induced myocardial structural disruption fibrosis rats, which by miR-21-3p. Mechanistically, accelerated M1 polarization. Both inhibitor CPT1A overexpression suppressed mitophagy. The inhibition reversed MiR-21-3p targeted mRNA co-localized protein In co-culture system macrophages H9c2 cells, mimics cells promoted polarization, whereas reduced phenotype. cell damage. These findings support potential therapeutic targeting regulate inducing Binding fatty acid metabolism-related target gene affects development chronic failure.

Язык: Английский

Процитировано

4
Methionine is an essential amino acid in doxorubicin-induced cardiotoxicity through modulating mitophagy DOI Creative Commons

Yijun Xin,

Yong Zhang, Zheng Yuan

и другие.

Free Radical Biology and Medicine, Год журнала: 2025, Номер 232, С. 28 - 39

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
New insights into mitochondrial quality control in anthracycline-induced cardiotoxicity: molecular mechanisms, therapeutic targets, and natural products DOI Creative Commons
Weili Li, Yuqin Zhang, Wei Yan

и другие.

International Journal of Biological Sciences, Год журнала: 2024, Номер 21(2), С. 507 - 523

Опубликована: Дек. 31, 2024

Anthracyclines (ANTs) are widely used in cancer therapy, particularly for lymphoma, sarcoma, breast cancer, and childhood leukemia, have become the cornerstone of chemotherapy various malignancies.However, it is associated with fatal dose-dependent cardiovascular complications, especially cardiotoxicity.Mitochondrial quality control mechanisms, encompassing mitophagy, mitochondrial dynamics, biogenesis, maintain homeostasis system.Recent studies highlighted that mechanisms play considerable roles ANTs-induced cardiotoxicity (AIC).In addition, natural products targeting emerged as potential therapeutic strategies to alleviate AIC.This review summarizes types, incidence, prevention, treatment, pathomechanism AIC, delves into molecular pathogenesis explores target these so provide targets drugs address clinical challenges AIC prevention where no effective medicines available.

Язык: Английский

Процитировано

0