The
administered
infusion
solution
is
a
sterile
preparation
that
can
be
used
directly
for
intravenous
in
patients
by
mixing
one
or
more
drugs
using
aseptic
operation
technology.
pharmacy
admixture
service
(PIVAS)
center
professional
technical
department
hospitals,
where
the
majority
of
inpatient-administered
solutions
are
prepared.
During
processes
dissolution,
dilution,
preparation,
storage,
and
use
drugs,
quality
control
affected
various
factors.
At
present,
there
no
relevant
standards
guidance
documents
solutions.
Cytotoxic
still
main
treatment
option
cancer
mainly
prepared
PIVAS
centers
most
hospitals.
In
this
study,
we
focused
on
cytotoxic
drug-administered
explored
associated
factors
(diluent,
container,
concentration,
temperature,
light),
physical
stability
(visual
appearance,
pH,
osmolality,
particulate
matter),
chemical
(content),
biological
(sterility).
Most
studies
reviewed
paper
have
insufficient
data
related
physicochemical
Research
sterility
particularly
limited,
with
only
article
addressing
aspect.
Ensuring
vital
safe
administration
to
patients,
so
it
very
important
enhance
research.
This
summarized
literature
provided
reference
safer
efficient
these
clinical
practice.
iScience,
Год журнала:
2024,
Номер
27(6), С. 109979 - 109979
Опубликована: Май 15, 2024
This
review
explores
the
hallmarks
of
cancer
resistance,
including
drug
efflux
mediated
by
ATP-binding
cassette
(ABC)
transporters,
metabolic
reprogramming
characterized
Warburg
effect,
and
dynamic
interplay
between
cells
mitochondria.
The
role
stem
(CSCs)
in
treatment
resistance
regulatory
influence
non-coding
RNAs,
such
as
long
RNAs
(lncRNAs),
microRNAs
(miRNAs),
circular
(circRNAs),
are
studied.
chapter
emphasizes
future
directions,
encompassing
advancements
immunotherapy,
strategies
to
counter
adaptive
integration
artificial
intelligence
for
predictive
modeling,
identification
biomarkers
personalized
treatment.
comprehensive
exploration
these
provides
a
foundation
innovative
therapeutic
approaches,
aiming
navigate
complex
landscape
enhance
patient
outcomes.
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июль 5, 2024
Abstract
Chemotherapy
is
currently
one
of
the
most
effective
methods
in
clinical
cancer
treatment.
However,
chemotherapy
resistance
an
important
reason
for
poor
efficacy
and
prognosis,
which
has
become
urgent
problem
to
be
solved
field
chemotherapy.
Therefore,
it
very
deeply
study
analyze
mechanism
its
regulatory
factors.
Long
non-coding
RNA
nuclear
paraspeckle
assembly
transcript
1
(LncRNA
NEAT1)
been
shown
closely
associated
with
cancer.
NEAT1
induces
cell
chemotherapeutic
drugs
by
regulating
apoptosis,
cycle,
drug
transport
metabolism,
DNA
damage
repair,
EMT,
autophagy,
stem
characteristics,
metabolic
reprogramming.
This
indicates
that
may
target
overcome
expected
a
potential
biomarker
predict
effect
article
summarizes
expression
characteristics
different
cancers,
discusses
role
related
molecular
mechanisms,
aiming
clarify
as
new
feasibility
sensitizers,
view
providing
therapeutic
direction
overcoming
dilemma
future.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Ноя. 11, 2024
Cancer
has
emerged
as
a
formidable
challenge
in
the
21st
century,
impacting
society,
public
health,
and
economy.
Conventional
cancer
treatments
often
exhibit
limited
efficacy
considerable
side
effects,
particularly
managing
advanced
stages
of
disease.
Photodynamic
therapy
(PDT),
contemporary
non-invasive
therapeutic
approach,
employs
photosensitizers
(PS)
conjunction
with
precise
light
wavelengths
to
selectively
target
diseased
tissues,
inducing
generation
reactive
oxygen
species
ultimately
leading
cell
apoptosis.
In
contrast
conventional
therapies,
PDT
presents
lower
incidence
effects
greater
precision
targeting.
The
integration
intelligent
nanotechnology
into
markedly
improved
its
effectiveness,
evidenced
by
remarkable
synergistic
antitumor
observed
utilization
multifunctional
nanoplatforms
PDT.
This
paper
provides
concise
overview
principles
underlying
PS
PDT,
while
also
delving
nanomaterial-based
context
treatment.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(11), С. 3202 - 3202
Опубликована: Май 29, 2024
Cancer
encompasses
various
elements
occurring
at
the
cellular
and
genetic
levels,
necessitating
an
immunotherapy
capable
of
efficiently
addressing
both
aspects.
T
cells
can
combat
cancer
by
specifically
recognizing
antigens
on
them.
This
innate
capability
has
been
used
to
develop
immunotherapies,
but
most
them
only
target
through
major
histocompatibility
complexes
(MHCs).
New
gene-editing
techniques
such
as
clustered
regularly
interspaced
short
palindromic
repeat
(CRISPR)-associated
protein
9
(CRISPR-cas9)
precisely
edit
DNA
sequences.
CRISPR-cas9
made
it
possible
generate
genetically
engineered
chimeric
antigen
receptors
(CARs)
that
overcome
problems
associated
with
old
immunotherapies.
In
receptor
(CAR-T)
cell
therapy,
patient's
are
isolated
modified
exhibit
synthetic
CAR(s).
CAR-T
treatment
shown
remarkably
positive
clinical
outcomes
in
cancers
types.
Nevertheless,
there
challenges
reduce
effectiveness
solid
tumors.
It
is
required
address
these
order
make
therapy
a
better
safer
option.
Combining
other
immunotherapies
multiple
outcomes.
Moreover,
recently
generated
Boolean
logic-gated
advanced
CARs
along
artificial
intelligence
expanded
its
potential
treat
tumors
addition
blood
cancers.
review
aims
describe
structure,
types,
methods
cells.
The
applications
hematological
malignancies
tumours
have
described
detail.
addition,
this
discussion
addressed
limitations
cells,
explored
strategies
mitigate
CAR-T-related
toxicities,
delved
into
future
perspectives.
Plasma,
Год журнала:
2024,
Номер
7(2), С. 465 - 497
Опубликована: Июнь 12, 2024
The
outstanding
properties
and
chemistry
of
cold
atmospheric
plasma
(CAP)
are
not
sufficiently
understood
due
to
their
relatively
complex
systems
transient
properties.
In
this
paper,
we
tried
present
a
detailed
review
the
applications
CAP
in
modern
medicine,
highlighting
biochemistry
phenomenon.
Due
its
unique
characteristics,
has
emerged
as
promising
tool
various
medical
applications.
CAP,
partially—or
fully
ionized—gas-retaining
state
quasi-neutrality,
contains
many
particles,
such
electrons,
charged
atoms,
molecules
displaying
collective
behaviour
caused
by
Coulomb
interactions.
can
be
generated
at
pressure,
making
it
suitable
for
settings.
Cold
plasma’s
anti-microbial
create
an
alternative
method
antibiotics
when
treating
infections.
It
also
enhances
cell
proliferation,
migration,
differentiation,
leading
accelerated
tissue
regeneration.
powerful
anti-tumour
therapies,
stem
dental
applications,
disease
treatment,
e.g.,
neurology.
is
our
belief
that
article
contributes
deeper
understanding
therapy
potential
medicine.
objective
study
demonstrate
novel
approach
treatment
modality.
By
covering
range
biomedical
fields,
hope
provide
comprehensive
overview
multiple
conditions.
order
gain
further
insight
into
subject,
attempted
gather
crucial
research
evidence
from
studies,
hopefully
creating
compelling
argument
favour
therapy.
Our
aim
highlight
innovative
aspects
where
traditional
methods
may
have
limitations.
Through
article,
intend
convenient
reference
source
readers
engaged
examination
CAP’s
