Ferroptosis inhibitors: past, present and future
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 23, 2024
Ferroptosis
is
a
non-apoptotic
mode
of
programmed
cell
death
characterized
by
iron
dependence
and
lipid
peroxidation.
Since
the
ferroptosis
was
proposed,
researchers
have
revealed
mechanisms
its
formation
continue
to
explore
effective
inhibitors
in
disease.
Recent
studies
shown
correlation
between
pathological
neurodegenerative
diseases,
as
well
diseases
involving
tissue
or
organ
damage.
Acting
on
ferroptosis-related
targets
may
provide
new
strategies
for
treatment
ferroptosis-mediated
diseases.
This
article
specifically
describes
metabolic
pathways
summarizes
reported
action
natural
synthetic
small
molecule
their
efficacy
The
paper
also
treatments
such
gene
therapy,
nanotechnology,
summarises
challenges
encountered
clinical
translation
inhibitors.
Finally,
relationship
other
modes
discussed,
hopefully
paving
way
future
drug
design
discovery.
Язык: Английский
Non-Coding RNA: A Key Regulator in the Glutathione-GPX4 Pathway of Ferroptosis
Non-coding RNA Research,
Год журнала:
2024,
Номер
9(4), С. 1222 - 1234
Опубликована: Май 20, 2024
Ferroptosis,
a
form
of
regulated
cell
death,
has
emerged
as
crucial
process
in
diverse
pathophysiological
states,
encompassing
cancer,
neurodegenerative
ailments,
and
ischemia-reperfusion
injury.
The
glutathione
(GSH)-dependent
lipid
peroxidation
pathway,
chiefly
governed
by
peroxidase
4
(GPX4),
assumes
an
essential
part
driving
ferroptosis.
GPX4,
the
principal
orchestrator
ferroptosis,
garnered
significant
attention
across
cardiovascular,
neuroscience
domains
over
past
decade.
Noteworthy
investigations
have
elucidated
indispensable
functions
ferroptosis
numerous
diseases,
including
tumorigenesis,
wherein
robust
within
cells
can
impede
tumor
advancement.
Recent
research
underscored
complex
regulatory
role
non-coding
RNAs
(ncRNAs)
regulating
GSH-GPX4
network,
thus
influencing
cellular
susceptibility
to
This
exhaustive
review
endeavors
probe
into
multifaceted
processes
which
ncRNAs
control
network
Specifically,
we
delve
miRNAs,
lncRNAs,
circRNAs
GPX4
expression
impacting
Moreover,
discuss
clinical
implications
dysregulated
interactions
between
several
conditions,
underscoring
their
capacity
viable
targets
for
therapeutic
intervention.
Additionally,
explores
emerging
strategies
aimed
at
targeting
modulate
pathway
manipulate
advantage.
A
comprehensive
understanding
these
intricate
networks
furnishes
insights
innovative
avenues
diseases
associated
with
perturbed
thereby
laying
groundwork
interventions
ferroptosis-related
pathological
conditions.
Язык: Английский
The Role of Ferroptosis in Osteoarthritis: Progress and Prospects
Biochemical and Biophysical Research Communications,
Год журнала:
2024,
Номер
733, С. 150683 - 150683
Опубликована: Сен. 10, 2024
Язык: Английский
Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option?
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8212 - 8212
Опубликована: Июль 27, 2024
Ferroptosis
is
a
form
of
iron-dependent
regulated
cell
death
caused
by
the
accumulation
lipid
peroxides.
In
this
review,
we
summarize
research
on
impact
ferroptosis
disease
models
and
isolated
cells
in
various
types
arthritis.
While
most
studies
have
focused
rheumatoid
arthritis
(RA)
osteoarthritis
(OA),
there
limited
spondylarthritis
crystal
arthropathies.
The
effects
inducing
or
inhibiting
strongly
depend
studied
type.
search
for
new
therapeutic
targets,
chondrocytes
might
promising
any
type
On
other
hand,
induction
may
also
lead
to
desired
decrease
synovial
fibroblasts
RA.
Thus,
must
consider
cell-type-specific
Further
investigation
needed
clarify
these
complexities.
Язык: Английский
Double-edged sword effect of GPX4 in skin homeostasis and diseases
Archives of Dermatological Research,
Год журнала:
2025,
Номер
317(1)
Опубликована: Фев. 14, 2025
Язык: Английский
Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 5, 2024
Osteoarthritis
(OA)
is
a
progressive
degenerative
disorder
impacting
bones
and
joints,
worsened
by
chronic
inflammation,
immune
dysregulation,
mechanical
stress,
metabolic
disturbances,
various
other
contributing
factors.
The
complex
interplay
of
cartilage
damage,
loss,
impaired
repair
mechanisms
remains
critical
formidable
aspect
OA
pathogenesis.
At
the
genetic
level,
multiple
genes
have
been
implicated
in
modulation
chondrocyte
metabolism,
displaying
both
promotive
inhibitory
roles.
Recent
research
has
increasingly
focused
on
influence
non-coding
RNAs
regulation
distinct
cell
types
within
bone
tissue
OA.
In
particular,
an
expanding
body
evidence
highlights
regulatory
roles
microRNAs
chondrocytes.
This
review
aims
to
consolidate
most
relevant
associated
with
chondrocytes,
as
identified
recent
studies,
elucidate
their
involvement
processes
ferroptosis.
Furthermore,
this
study
explores
interactions
between
long
(lncRNAs)
circular
(circRNAs)
OA,
emphasis
microRNA-mediated
mechanisms.
Finally,
gaps
current
are
identified,
offering
strategic
insights
advance
understanding
pathophysiology
guide
therapeutic
developments
field.
Язык: Английский