Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 2485 - 2529
Опубликована: Июнь 1, 2024
Abstract:
Ferroptosis,
a
unique
form
of
programmed
cell
death,
is
initiated
by
an
excess
iron
accumulation
and
lipid
peroxidation-induced
damage.
There
growing
body
evidence
indicating
that
ferroptosis
plays
critical
role
in
the
advancement
tumors.
The
increased
metabolic
activity
higher
levels
tumor
cells
make
them
particularly
vulnerable
to
ferroptosis.
As
result,
targeted
induction
becoming
increasingly
promising
approach
for
cancer
treatment.
This
review
offers
overview
regulatory
mechanisms
ferroptosis,
delves
into
mechanism
action
traditional
small
molecule
inducers
their
effects
on
various
In
addition,
latest
progress
inducing
using
new
means
such
as
proteolysis-targeting
chimeras
(PROTACs),
photodynamic
therapy
(PDT),
sonodynamic
(SDT)
nanomaterials
summarized.
Finally,
this
discusses
challenges
opportunities
development
ferroptosis-inducing
agents,
focusing
discovering
targets,
improving
selectivity,
reducing
toxic
side
effects.
Keywords:
inducers,
molecules,
PROTACs,
PDT,
SDT,
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 26, 2025
Lung
cancer
(LC)
is
a
highly
prevalent
and
deadly
type
of
characterized
by
intricate
molecular
pathways
that
drive
tumor
development,
metastasis,
resistance
to
conventional
treatments.
Recently,
ferroptosis,
controlled
mechanism
cell
death
instigated
iron-dependent
lipid
peroxidation,
has
gained
attention
for
its
role
in
LC
progression
treatment.
Noncoding
RNAs
(ncRNAs),
such
as
microRNAs
(miRNAs)
long
noncoding
(lncRNAs),
are
emerging
key
modulators
significantly
influencing
biology.
This
review
explores
how
ncRNAs
control
ferroptotic
affect
growth,
therapy
LC.
By
understanding
the
dual
functions
both
activating
inhibiting
we
aim
uncover
new
therapeutic
targets
strategies
These
insights
provide
promising
direction
development
ncRNA-based
treatments
designed
induce
potentially
improving
outcomes
patients
with
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 265 - 265
Опубликована: Янв. 22, 2025
Ferroptosis,
characterized
by
iron
dependency
and
lipid
peroxidation,
has
emerged
as
a
key
mechanism
underlying
neurodegeneration
in
rare
neurological
disorders.
These
conditions,
often
marked
significant
therapeutic
gaps
high
unmet
medical
needs,
present
unique
challenges
for
intervention
development.
This
review
examines
the
involvement
of
ferroptosis
disease
pathogenesis,
focusing
on
its
role
oxidative
damage
neuronal
dysfunction.
We
explore
recent
pharmacological
advancements,
including
chelators,
peroxidation
blockers,
antioxidant-based
strategies,
designed
to
target
ferroptosis.
While
these
approaches
show
promise,
such
heterogeneity,
limited
diagnostic
tools,
small
patient
cohorts
hinder
progress.
Furthermore,
we
discuss
translational
regulatory
barriers
implementing
ferroptosis-based
therapies
clinical
practice.
By
addressing
obstacles
fostering
innovative
solutions,
this
underscores
potential
ferroptosis-targeting
strategies
revolutionize
treatment
paradigms
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 7, 2025
Synchrotron-radiation
nano-X-Ray
Fluorescence
(XRF)
is
a
cutting-edge
technique
offering
high-resolution
insights
into
the
elemental
composition
of
biological
tissues,
shedding
light
on
metabolic
processes
and
element
localization
within
cellular
structures.
In
context
Idiopathic
Pulmonary
Fibrosis
(IPF),
debilitating
lung
condition
associated
with
respiratory
complications
reduced
life
expectancy,
nano-XRF
presents
promising
avenue
for
understanding
disease's
intricate
pathology.
Our
developed
workflow
enables
assessment
in
both
human
rodent
fibrotic
providing
interplay
between
compartments
chronic
diseases.
findings
demonstrate
trace
accumulations
anthracosis,
feature
observed
IPF.
Notably,
Zn
Ca
clusters
approximately
750
nm
size
were
identified
exclusively
IPF
samples.
While
their
specific
role
remains
unclear,
presence
may
be
disease-specific
processes.
Additionally,
we
Fe
S
signal
colocalization
650-nm
structures
some
cells.
Fe-S
complexes
mitochondria
are
known
to
increased
ROS
production,
suggesting
potential
connection
disease
contrast,
bleomycin-induced
fibrosis
model
exhibits
different
phenotype
low
S,
Zn,
Ca.
Overall,
our
highlights
effectiveness
synchrotron-based
mapping
analyzing
spatial
distribution
elements
diseased
tissue,
valuable
aspects
related
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 334 - 334
Опубликована: Фев. 26, 2025
In
recent
years,
ferroptosis,
as
an
emerging
modality
of
programmed
cell
death,
has
captured
significant
attention
within
the
scientific
community.
This
comprehensive
review
meticulously
canvasses
pertinent
literature
past
few
spanning
multiple
facets.
It
delves
into
intricate
mechanisms
underpinning
tracks
evolution
its
inducers
and
inhibitors,
dissects
roles
in
a
diverse
array
diseases,
well
resultant
therapeutic
implications.
A
profound
exploration
is
conducted
functional
ferroptosis-related
molecules,
intracellular
pathways,
metabolic
cascades,
signaling
transduction
routes.
Novel
ferroptosis
inhibitors
are
introduced
detail,
covering
their
design
blueprints,
synthetic
methodologies,
bioactivity
profiles.
Moreover,
exhaustive
account
provided
regarding
involvement
malignancies,
neurodegenerative
disorders,
cardiovascular
ailments,
other
pathologies.
By
highlighting
pivotal
status
potential
regimens
various
this
aspires
to
furnish
thorough
reference
framework
for
future
investigations
clinical
translations
domain.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 24, 2025
Flavonoids
are
a
class
of
important
polyphenolic
compounds,
renowned
for
their
antioxidant
properties.
However,
recent
studies
have
uncovered
an
additional
function
these
natural
flavonoids:
ability
to
inhibit
ferroptosis.
Ferroptosis
is
key
mechanism
driving
cell
death
in
central
nervous
system
(CNS)
diseases,
including
both
acute
injuries
and
chronic
neurodegenerative
disorders,
characterized
by
iron
overload-induced
lipid
peroxidation
dysfunction
the
defense
system.
This
review
discusses
therapeutic
potential
flavonoids
from
herbs
nutraceuticals
as
ferroptosis
inhibitors
CNS
focusing
on
molecular
mechanisms,
summarizing
findings
preclinical
animal
models,
providing
insights
clinical
translation.
We
specifically
highlight
such
Baicalin,
Baicalein,
Chrysin,
Vitexin,
Galangin,
Quercetin,
Isoquercetin,
Eriodictyol,
Proanthocyanidin,
(−)-epigallocatechin-3-gallate,
Dihydromyricetin,
Soybean
Isoflavones,
Calycosin,
Icariside
II,
Safflower
Yellow,
which
shown
promising
results
models
injuries,
ischemic
stroke,
cerebral
ischemia-reperfusion
injury,
intracerebral
hemorrhage,
subarachnoid
traumatic
brain
spinal
cord
injury.
Among
these,
Baicalin
its
precursor
Baicalein
stand
out
due
extensive
research
favorable
outcomes
injury
models.
Mechanistically,
not
only
regulate
Nrf2/ARE
pathway
activate
GPX4/GSH-related
pathways
but
also
modulate
metabolism
proteins,
thereby
alleviating
overload
inhibiting
While
show
promise
especially
settings,
further
needed
evaluate
efficacy,
safety,
pharmacokinetics,
blood-brain
barrier
penetration
application.
