The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions DOI Creative Commons

Gi Beom Lee,

Saeyoung Park, Un Ju Jung

и другие.

Biomedicines, Год журнала: 2024, Номер 12(11), С. 2507 - 2507

Опубликована: Ноя. 1, 2024

Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused cerebellar dysfunction. The absence of treatments approved the U.S. Food Drug Administration for SCA has driven investigation alternative therapeutic strategies, including stem cell therapy. Mesenchymal cells (MSCs), known their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, modulate brain inflammation. Recent findings from preclinical clinical studies are also reviewed, emphasizing promise MSC therapy addressing unmet needs patients. Furthermore, ongoing trials future directions proposed to address limitations current approaches.

Язык: Английский

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Boost Functional Performance in an Animal Model of Multiple Sclerosis Through Recruiting Oligodendrocytes and Attenuating Gliosis DOI

S Mohammadhadi Mirab,

Ameneh Omidi,

Masoud Soleimani

и другие.

Stem Cell Reviews and Reports, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

0
Research landscape and trends of human umbilical cord mesenchymal stem cell-derived exosomes DOI Creative Commons
Desheng Chen,

Zaoping Chen,

Jiabin Yuan

и другие.

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Май 28, 2025

Язык: Английский

Процитировано

0
The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions DOI Creative Commons

Gi Beom Lee,

Saeyoung Park, Un Ju Jung

и другие.

Biomedicines, Год журнала: 2024, Номер 12(11), С. 2507 - 2507

Опубликована: Ноя. 1, 2024

Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused cerebellar dysfunction. The absence of treatments approved the U.S. Food Drug Administration for SCA has driven investigation alternative therapeutic strategies, including stem cell therapy. Mesenchymal cells (MSCs), known their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, modulate brain inflammation. Recent findings from preclinical clinical studies are also reviewed, emphasizing promise MSC therapy addressing unmet needs patients. Furthermore, ongoing trials future directions proposed to address limitations current approaches.

Язык: Английский

Процитировано

0