The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions DOI Creative Commons

Gi Beom Lee,

Saeyoung Park, Un Ju Jung

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2507 - 2507

Published: Nov. 1, 2024

Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused cerebellar dysfunction. The absence of treatments approved the U.S. Food Drug Administration for SCA has driven investigation alternative therapeutic strategies, including stem cell therapy. Mesenchymal cells (MSCs), known their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, modulate brain inflammation. Recent findings from preclinical clinical studies are also reviewed, emphasizing promise MSC therapy addressing unmet needs patients. Furthermore, ongoing trials future directions proposed to address limitations current approaches.

Language: Английский

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Boost Functional Performance in an Animal Model of Multiple Sclerosis Through Recruiting Oligodendrocytes and Attenuating Gliosis DOI

S Mohammadhadi Mirab,

Ameneh Omidi,

Masoud Soleimani

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

Citations

0
The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions DOI Creative Commons

Gi Beom Lee,

Saeyoung Park, Un Ju Jung

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2507 - 2507

Published: Nov. 1, 2024

Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused cerebellar dysfunction. The absence of treatments approved the U.S. Food Drug Administration for SCA has driven investigation alternative therapeutic strategies, including stem cell therapy. Mesenchymal cells (MSCs), known their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, modulate brain inflammation. Recent findings from preclinical clinical studies are also reviewed, emphasizing promise MSC therapy addressing unmet needs patients. Furthermore, ongoing trials future directions proposed to address limitations current approaches.

Language: Английский

Citations

0