Sex-specific behavioral, cardiac, and neuroendocrine responses to repeated witness social stress in adult rats

Physiology & Behavior, Год журнала: 2024, Номер 287, С. 114702 - 114702

Опубликована: Сен. 25, 2024

In humans, sex disparities exist in the prevalence of social stress-related disorders, yet our understanding predisposing factors and underlying mechanisms is still elusive. Also at preclinical level, investigation differences stress responses limited. this study, adult male female wild-type Groningen rats were repeatedly exposed to witness defeat (WS) assess sex-specific behavioral, neuroendocrine, cardiac same paradigm. Male bore an aggressive episode between two males for nine consecutive days or a control (CTR) procedure. Stress-related parameters assessed correspondence first last WS/CTR exposure also during subsequent context alone absence defeat. During WS, both sexes displayed larger amounts burying behavior smaller rearing grooming behaviors, but with greater extent witnesses. Cardiac autonomic WS similar sexes, only females higher plasma corticosterone levels after compared CTRs, had increase than witnesses upon repeated WS. Exposure (i.e., without presence resident rat) elicited amount more pronounced persistent tachycardic history Our findings suggest sex-disparities response multiple cardiac, neuroendocrine levels, highlighting utility paradigm investigating pathophysiological vulnerabilities pathologies.

Язык: Английский

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The influence of long-term housing in enriched environment on behavior of normal rats and subjected to neonatal pro-inflammatory challenge

Brain Behavior & Immunity - Health, Год журнала: 2023, Номер 30, С. 100639 - 100639

Опубликована: Май 24, 2023

It is well known that neonatal pro-inflammatory challenge (NPC) acquire a predisposition to the development of number neuropsychiatric diseases: depression, anxiety disorders, autism, attention deficit hyperactivity disorder. Symptoms these diseases can manifest themselves in adulthood and adolescent after repeated exposure negative influences. Preventing consequences NPC one main tasks for researchers. The an enriched environment (EE) was shown have anxiolytic, anti-depressive, pro-cognitive effects. present work aimed investigate effects long-term EE on anxious-depressive conditioned fear behavior normal male female rats subjected NPC. induced by subcutaneous administration lipopolysaccharide (LPS, 50 μg/kg) 3d 5th PNDs. control animals received saline (SAL). were placed from 25 120 PND. Animals housed standard conditions (STAND) served as controls. In adult STAND groups, LPS did not affect anxiety, depressive-like fear. increased motor search activity males females. open field, reduced SAL groups females compared animals. elevated plus maze, decreased only group. sucrose preference test, change consumption while, forced swimming both groups. enrichment contextual but group, cue corticosterone reactivity stress basal level IL-1beta blood serum SAL-EE Thus, males, females, Although behaviors prevented beneficial opposing dependent sex type testing.

Язык: Английский

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FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Δ9 tetrahydrocannabinol inhalation in mice

Pharmacology Biochemistry and Behavior, Год журнала: 2023, Номер 231, С. 173633 - 173633

Опубликована: Сен. 15, 2023

Язык: Английский

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Nine-month-long Social Isolation Changes the Levels of Monoamines in the Brain Structures of Rats: A Comparative Study of Neurochemistry and Behavior

Neurochemical Research, Год журнала: 2023, Номер 48(6), С. 1755 - 1774

Опубликована: Янв. 21, 2023

Язык: Английский

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Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression

Neural Regeneration Research, Год журнала: 2024, Номер unknown

Опубликована: Янв. 8, 2024

Abstract It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, loss of sexual function, there are a variety secondary complications, including memory loss, cognitive decline, depression, Alzheimer’s disease. The large-scale longitudinal population-based studies indicate post-trauma depression is highly prevalent patients. Yet, few basic have conducted to address the potential molecular mechanisms. One possible factors underlying reduction adult hippocampal neurogenesis which may come from less physical activity, social isolation, chronic elevated neuroinflammation after injury. However, no clear consensus yet. In this review, we will first summarize alteration post-spinal Then, discuss mechanisms underlie important consequence. Finally, outline therapeutic options aimed at enhancing ameliorate depression.

Язык: Английский

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Effect of Long-Term Social Isolation on Behavior and Brain Dopaminergic System in Mice

Journal of Evolutionary Biochemistry and Physiology, Год журнала: 2024, Номер 60(1), С. 397 - 408

Опубликована: Янв. 1, 2024

Язык: Английский

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The role of gender differences in the outcome of juvenile social isolation: Emphasis on changes in behavioral, biochemical and expression of nitric oxide synthase genes alteration

Heliyon, Год журнала: 2024, Номер 10(7), С. e28964 - e28964

Опубликована: Апрель 1, 2024

Social isolation can cause serious problem in performance of individuals community. As gender differences may variation results the severity depressive behavior and response patients to therapy, impact interaction level endocrine secretion depression were investigated this study. Wistar rats both sexes subjected post-weaning social (PWSI) conditions and, together with control group, experienced several behavioral tests including open-field Test (OFT), elevated plus maze (EPM), force swimming test (FST), splash novel object recognition (NOR). Hippocampal tissue was isolated measure biochemical factors such as nitric oxide level, FRAP amount, MDA level. In addition, real-time-PCR used quantify genes expression inducible synthase (iNOS) neuronal (nNOS). On other hand, sexual hormone levels blood measured. Both cognitive f unctions declined result PWSI induction male diestrus female rats. The consequent surge estradiol during estrous phase seems suppress accumulation reactive oxygen species (ROS), modulate iNOS nNOS expression. conclusion, while pattern cellular antioxidants, raising ROS is gender-specific, alleviation relation drop unrelated testosterone

Язык: Английский

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Increased Threat Learning After Social Isolation in Human Adolescents

Опубликована: Июль 30, 2024

In animal models, social isolation impacts threat responding and learning, especially during development. This study examined the effects of acute on learning in human adolescents using an experimental, within-participant design. Participants aged 16-19 years underwent a session complete separate with virtual interactions, counterbalanced between participants, as well baseline session. At following each session, participants reported their psychological state completed task which self-report ratings physiological responses to learned safety cues were measured. Threat increased after both sessions two ways. First, found cue more anxiety-inducing unpleasant compared baseline. Second, extinction, electrodermal activity was partially elevated Further, results suggested that influenced through loneliness. is central threat-related disorders including anxiety, phobias, obsessive-compulsive disorder (OCD) post-traumatic stress (PTSD), our findings suggest loneliness adolescence might increase vulnerability emergence these learning.

Язык: Английский

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Bromelain prevented the onset of psychotic behaviours in social-isolation model of schizophrenia by inhibiting astrogliosis and oxido-inflammatory damage in male and female mice

Nutrire, Год журнала: 2024, Номер 49(2)

Опубликована: Июль 31, 2024

Язык: Английский

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Anxiolytic-like effects of acute serotonin-releasing agents in zebrafish models of anxiety: experimental study and systematic review

Acta Neuropsychiatrica, Год журнала: 2024, Номер unknown, С. 1 - 19

Опубликована: Окт. 28, 2024

Abstract Though commonly used to model affective disorders, zebrafish display notable differences in terms of the structure and function brain serotonin system, including responses pharmacological interventions, as compared mammals. For example, elevation following acute administration reuptake inhibitors (SRIs) generally has anxiogenic effects, both clinical situation rodent models anxiety, but previous research indicated opposite zebrafish. However, several issues remain unresolved. We conducted a systematic review SRI effects anxiety and, on basis these results, performed series experiments further investigating influence serotonin-releasing agents anxiety-like behaviour zebrafish, with sex-segregated wild-type animals being administered either escitalopram, or releaser fenfluramine, light-dark test. In review, we find that available literature indicates an anxiolytic-like effect SRIs novel-tank diving Regarding test, most studies reported no behavioural SRIs, although few did saw responses. experimental studies, consistent were observed neither sex nor habituation influencing treatment response. general indeed appears be anxiolytic-like, indicating, at least partly, functioning system mammals caution is advised when using disorders.

Язык: Английский

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