Influence of long-term social isolation on the behavior and dopamine system of the brain in mice DOI
Д. В. Базовкина,

U. S. Ustinova,

S. N. Adonina

et al.

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(2), P. 238 - 253

Published: Aug. 2, 2024

The dopamine brain system is involved in the regulation of various physiological processes and behavioral responses, including social behavior. It was shown rodents that prolonged isolation can lead to changes parameters neurochemical parameters, but these data remain unclear. In this work, we studied effects on behavior state male C57Bl/6 mice. Animals experimental group from age 40 - 42 days were kept individually separate cages for six weeks, while mice control in-group conditions. Isolation did not affect locomotor exploratory activity “open field” test compared content group. At same time, animals subjected demonstrated a longer duration contacts “resident-intruder” model weakening stereotypical “marbles burying” These accompanied by an increase mRNA levels genes encoding D1 D2 receptors striatum addition, level metabolite DOPAC decreased hypothalamus increased frontal cortex due effect with results contribute understanding

Language: Английский

Role of Acorus calamus in preventing depression, anxiety, and oxidative stress in long-term socially isolated rats DOI Creative Commons
R. Ashwin, Teresa Joy, Meghana S. Poojari

et al.

Veterinary World, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 1, 2023

Background and Aim: Social isolation stress (SIS) individual housing have been shown to cause abnormal cognitive insufficiencies, altered anxiety levels, signs of psychiatric diseases. Acorus calamus (AC), commonly known as Sweet Flag, has widely used in India treat neurological, metabolic, respiratory disorders, indicating its potential therapeutic value. This study aimed determine the antidepressant antioxidative effects AC on rats subjected long-term, social-isolation-induced stress. Materials Methods: involved 2-month-old male (24) weighing approximately 180200 g bred in-house. The were divided into four groups (n = 6): Group-1 received saline, Group-2 SIS, Group-3 only 50mg/kg AC, Group-4 SIS for 6 weeks. After this, behavioral, biochemical, neuronal assay was conducted. Results: Behavioral experiments showed significantly higher activity levels (p < 0.001) AC-treated than group. In addition, with treatment exhibited enhanced total antioxidants, superoxide dismutase, assays compared alone. Conclusion: improved antioxidant against rat brain tissue. Moreover, we proved that can effectively reverse neurotoxicity induced by animal models. As battle coronavirus disease 2019 pandemic social isolation, could be considered a supplementary alleviate depressive-like symptoms our present-day lifestyle. Keywords: antidepressant, effects, tissue, pandemic.

Language: Английский

Citations

7
FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Δ9 tetrahydrocannabinol inhalation in mice DOI Creative Commons
Samantha L. Penman,

Nicole Roeder,

Erin C. Berthold

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2023, Volume and Issue: 231, P. 173633 - 173633

Published: Sept. 15, 2023

Language: Английский

Citations

6
The role of gender differences in the outcome of juvenile social isolation: Emphasis on changes in behavioral, biochemical and expression of nitric oxide synthase genes alteration DOI Creative Commons
Soroush Bijani,

Fatemeh Sadat Kashfi,

Sadaf Zahedi-Vanjani

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28964 - e28964

Published: April 1, 2024

Social isolation can cause serious problem in performance of individuals community. As gender differences may variation results the severity depressive behavior and response patients to therapy, impact interaction level endocrine secretion depression were investigated this study. Wistar rats both sexes subjected post-weaning social (PWSI) conditions and, together with control group, experienced several behavioral tests including open-field Test (OFT), elevated plus maze (EPM), force swimming test (FST), splash novel object recognition (NOR). Hippocampal tissue was isolated measure biochemical factors such as nitric oxide level, FRAP amount, MDA level. In addition, real-time-PCR used quantify genes expression inducible synthase (iNOS) neuronal (nNOS). On other hand, sexual hormone levels blood measured. Both cognitive f unctions declined result PWSI induction male diestrus female rats. The consequent surge estradiol during estrous phase seems suppress accumulation reactive oxygen species (ROS), modulate iNOS nNOS expression. conclusion, while pattern cellular antioxidants, raising ROS is gender-specific, alleviation relation drop unrelated testosterone

Language: Английский

Citations

1
Social isolation induces addictive behavior and increases release of dopamine in the <i>nucleus accumbens</i> in response to stimulation of the positive reinforcing zone DOI

S. S. Pyurveev,

А. А. Лебедев,

V. V. Sizov

et al.

Журнал высшей нервной деятельности им И П Павлова, Journal Year: 2024, Volume and Issue: 74(4), P. 471 - 485

Published: Nov. 9, 2024

Language: Английский

Citations

1
Myelin Transcription Factor 1 (MyT1) overexpression mitigates social isolation-induced behavioral deficits: Insights into cortical synaptotagmin 1 regulation and antidepressant-like effects DOI
Amine Bahí, Jean‐Luc Dreyer

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: unknown, P. 173912 - 173912

Published: Nov. 1, 2024

Language: Английский

Citations

1
Effect of Long-Term Social Isolation on Behavior and Brain Dopaminergic System in Mice DOI
Д. В. Базовкина,

U. S. Ustinova,

S. N. Adonina

et al.

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(1), P. 397 - 408

Published: Jan. 1, 2024

Language: Английский

Citations

1
Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for psychiatric disorders and metabolic dysfunction DOI
Louis J. Kolling, Kanza M. Khan, Ruixiang Wang

et al.

Psychiatry Research, Journal Year: 2024, Volume and Issue: 337, P. 115951 - 115951

Published: May 8, 2024

Language: Английский

Citations

1
Increased Threat Learning After Social Isolation in Human Adolescents DOI Open Access
Emily Towner, Kirsten Thomas, Livia Tomova

et al.

Published: July 30, 2024

In animal models, social isolation impacts threat responding and learning, especially during development. This study examined the effects of acute on learning in human adolescents using an experimental, within-participant design. Participants aged 16-19 years underwent a session complete separate with virtual interactions, counterbalanced between participants, as well baseline session. At following each session, participants reported their psychological state completed task which self-report ratings physiological responses to learned safety cues were measured. Threat increased after both sessions two ways. First, found cue more anxiety-inducing unpleasant compared baseline. Second, extinction, electrodermal activity was partially elevated Further, results suggested that influenced through loneliness. is central threat-related disorders including anxiety, phobias, obsessive-compulsive disorder (OCD) post-traumatic stress (PTSD), our findings suggest loneliness adolescence might increase vulnerability emergence these learning.

Language: Английский

Citations

1
Bromelain prevented the onset of psychotic behaviours in social-isolation model of schizophrenia by inhibiting astrogliosis and oxido-inflammatory damage in male and female mice DOI

Gideon Opeyemi Ayilara,

Bamidele Victor Owoyele

Nutrire, Journal Year: 2024, Volume and Issue: 49(2)

Published: July 31, 2024

Language: Английский

Citations

1
Anxiolytic-like effects of acute serotonin-releasing agents in zebrafish models of anxiety: experimental study and systematic review DOI Creative Commons
Jakob Näslund,

Jenny Landin,

Fredrik Hieronymus

et al.

Acta Neuropsychiatrica, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: Oct. 28, 2024

Abstract Though commonly used to model affective disorders, zebrafish display notable differences in terms of the structure and function brain serotonin system, including responses pharmacological interventions, as compared mammals. For example, elevation following acute administration reuptake inhibitors (SRIs) generally has anxiogenic effects, both clinical situation rodent models anxiety, but previous research indicated opposite zebrafish. However, several issues remain unresolved. We conducted a systematic review SRI effects anxiety and, on basis these results, performed series experiments further investigating influence serotonin-releasing agents anxiety-like behaviour zebrafish, with sex-segregated wild-type animals being administered either escitalopram, or releaser fenfluramine, light-dark test. In review, we find that available literature indicates an anxiolytic-like effect SRIs novel-tank diving Regarding test, most studies reported no behavioural SRIs, although few did saw responses. experimental studies, consistent were observed neither sex nor habituation influencing treatment response. general indeed appears be anxiolytic-like, indicating, at least partly, functioning system mammals caution is advised when using disorders.

Language: Английский

Citations

1