The mechanism of ferroptosis and its related diseases

Molecular Biomedicine, Год журнала: 2023, Номер 4(1)

Опубликована: Окт. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Язык: Английский

---

Ferroptosis and the ubiquitin-proteasome system: exploring treatment targets in cancer

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 11, 2024

Ferroptosis is an emerging mode of programmed cell death fueled by iron buildup and lipid peroxidation. Recent evidence points to the function ferroptosis in aetiology development cancer other disorders. Consequently, harnessing for disease treatment has diverted interest researchers field basic clinical research. The ubiquitin-proteasome system (UPS) represents a primary protein degradation pathway eukaryotes. It involves labelling proteins be degraded ubiquitin (Ub), followed recognition proteasome. Dysfunction UPS can contribute diverse pathological processes, emphasizing importance maintaining organismal homeostasis. regulation stability critical component intricate molecular mechanism underlying death. Moreover, involvement regulating death-related molecules signaling pathways, providing valuable insights targeted strategies. Besides, it highlights potential as promising target therapy, combination between UPS. mechanisms ferroptosis, including key regulators such glutathione peroxidase 4 (GPX4), cysteine/glutamate transporter (system XC-), metabolism, are thoroughly examined, alongside role modulating abundance activity crucial ferroptotic death, GPX4, nuclear factor erythroid 2–related 2 (NRF2). As pivotal regulatory macromolecular homeostasis, substantially impacts directly or indirectly associated pathways. This review explores diseases with ferroptosis.

Язык: Английский

---

Gasdermin E as a potential target and biomarker for CRISPR-Cas9-based cancer therapy

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116961 - 116961

Опубликована: Апрель 1, 2025

Язык: Английский

---

Comprehensive review of perioperative factors influencing ferroptosis

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117375 - 117375

Опубликована: Сен. 14, 2024

Язык: Английский

---