Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases DOI Creative Commons

Rachid Kacemi,

María G. Campos

Antioxidants, Год журнала: 2025, Номер 14(3), С. 265 - 265

Опубликована: Фев. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Язык: Английский

Oxidative stress’s impact on red blood cells: Unveiling implications for health and disease DOI Creative Commons
Emmanuel Ifeanyi Obeagu, Matthew Chibunna Igwe,

Getrude Uzoma Obeagu

и другие.

Medicine, Год журнала: 2024, Номер 103(9), С. e37360 - e37360

Опубликована: Март 1, 2024

Oxidative stress, a condition characterized by an imbalance between reactive oxygen species (ROS) production and the body's ability to detoxify them, has emerged as pivotal factor in pathophysiology of various diseases. Red blood cells (RBCs), essential components circulatory system, are particularly susceptible oxidative damage due their high oxygen-carrying capacity abundance vulnerable biomolecules. This review comprehensively explores intricate mechanisms underlying stress-induced red subsequent implications for overall health disease. We delve into sources ROS generation within RBCs, including metabolic processes external factors, shedding light on delicate redox balance that governs cellular homeostasis. The impact stress extends beyond confines primary physiological role, these actively participate immune responses, inflammation modulation, nitric oxide metabolism. Consequently, understanding RBCs provides valuable insights broader landscape In conclusion, this underscores critical role influencing cell physiology its far-reaching human health. Elucidating molecular intricacies relationship not only enhances our fundamental biological but also paves way development targeted therapeutic interventions mitigate adverse effects and, extension,

Язык: Английский

Процитировано

20
Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors DOI Creative Commons

Carolina Punziano,

Silvia Trombetti, Elena Cesaro

и другие.

Antioxidants, Год журнала: 2024, Номер 13(3), С. 298 - 298

Опубликована: Фев. 28, 2024

Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, ischemia–reperfusion injuries. linked iron accumulation, eliciting dysfunction antioxidant systems, which favor the production lipid peroxides, membrane damage, ultimately, death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against excess and/or lipid-derived ROS. Here, we discuss interaction between metabolic particular focus on transcription factors implicated in regulation ferroptosis, either as triggers peroxidation or defense pathways.

Язык: Английский

Процитировано

15
In defence of ferroptosis DOI Creative Commons
Francesca M. Alves, Darius J.R. Lane,

Triet Phu Minh Nguyen

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 2, 2025

Abstract Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is restrained cellular defences. Ferroptosis increasingly implicated in a host of diseases, and unlike other cell death programs the physiological initiation conceived to occur not an endogenous executioner, but withdrawal guardians that otherwise constantly oppose induction. Here, we profile key ferroptotic defence strategies including regulation, modulation enzymes metabolite systems: glutathione reductase (GR), suppressor protein 1 (FSP1), NAD(P)H Quinone Dehydrogenase (NQO1), Dihydrofolate (DHFR), retinal reductases dehydrogenases (RDH) thioredoxin (TR). A common thread uniting all metabolites combat lipid during dependence on reductant, nicotinamide adenine dinucleotide phosphate (NADPH). We will outline how cells control central carbon metabolism produce NADPH necessary precursors defend against ferroptosis. Subsequently discuss evidence for dysregulation different disease contexts glucose-6-phosphate dehydrogenase deficiency, cancer neurodegeneration. Finally, several anti-ferroptosis therapeutic spanning use radical trapping agents, dependent redox support highlight current landscape clinical trials focusing

Язык: Английский

Процитировано

2
Ferroptosis role in complexity of cell death: unrevealing mechanisms in Parkinson’s disease and therapeutic approaches DOI
Anupam Awasthi,

Kousik Maparu,

Shamsher Singh

и другие.

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

2
Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases DOI Creative Commons

Liuting Zeng,

Kailin Yang,

Ganpeng Yu

и другие.

Cell Death and Disease, Год журнала: 2024, Номер 15(7)

Опубликована: Июль 4, 2024

Abstract Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with cells being a crucial component body’s system. This review provides an overview discusses relationship between ferroptosis, programmed cell death cells, autoimmune diseases. Additionally, it summarizes key targets such as GPX4 TFR, responses. Furthermore, release multiple molecules, including damage-associated molecular patterns (DAMPs), following by is examined, these molecules further influence differentiation function thereby affecting occurrence progression Moreover, secrete factors or metabolites, which also impact target organs tissues involved Iron chelators, chloroquine its derivatives, antioxidants, calreticulin have been demonstrated to be effective animal studies for certain diseases, exerting anti-inflammatory immunomodulatory effects. Finally, brief summary future perspectives on are provided, aiming guide disease treatment strategies.

Язык: Английский

Процитировано

8
Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy DOI
Weijia Wang,

Behishta Hashimi,

Ping Wang

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Язык: Английский

Процитировано

1
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling DOI
Qian Yao,

Qiangqiang Shi,

Wanting Zhou

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 134, С. 112165 - 112165

Опубликована: Май 1, 2024

Язык: Английский

Процитировано

6
The interplay of transition metals in ferroptosis and pyroptosis DOI Creative Commons

Frantisek Vana,

Zoltán Szabó, Michal Masařík

и другие.

Cell Division, Год журнала: 2024, Номер 19(1)

Опубликована: Авг. 3, 2024

Cell death is one of the most important mechanisms maintaining homeostasis in our body. Ferroptosis and pyroptosis are forms necrosis-like cell death. These modalities play key roles pathophysiology cancer, cardiovascular, neurological diseases, other pathologies. Transition metals abundant group elements all living organisms. This paper presents a summary ferroptosis pathways their connection to significant transition metals, namely zinc (Zn), copper (Cu), molybdenum (Mo), lead (Pb), cobalt (Co), iron (Fe), cadmium (Cd), nickel (Ni), mercury (Hg), uranium (U), platinum (Pt), crucial element, selenium (Se). Authors aim summarize up-to-date knowledge this topic.In review, there categorized highlighted common patterns alterations by metals. Special attention given since collected data support its dual nature action both pyroptosis. All findings presented together with brief description major biochemical involving mentioned visualized attached comprehensive figures.This work concludes that majority disruptions studied metals' impacts fate, influencing survival cells complex system altered pathways. Therefore, opens up space for further research.

Язык: Английский

Процитировано

6
Cellular preconditioning and mesenchymal stem cell ferroptosis DOI
Doaa Hussein Zineldeen, Mazhar Mushtaq, Khawaja Husnain Haider

и другие.

World Journal of Stem Cells, Год журнала: 2024, Номер 16(2), С. 64 - 69

Опубликована: Фев. 25, 2024

In this editorial, we comment on the article published in recent issue of

Язык: Английский

Процитировано

5
The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide DOI Creative Commons
Shijian Feng,

Xiaofang Huang,

Dan Tang

и другие.

MedComm, Год журнала: 2024, Номер 5(3)

Опубликована: Фев. 26, 2024

Ferroptosis is a recently discovered form of regulated cell death characterized by its distinct dependence on iron and the peroxidation lipids within cellular membranes. plays crucial role in physiological pathological situations has attracted attention numerous scientists. suppressive protein 1 (FSP1) one main regulators that negatively regulates ferroptosis through GPX4-independent FSP1-CoQ10-NAD(P)H axis potential therapeutic target for ferroptosis-related diseases. However, crystal structure FSP1 not been resolved, which hinders development strategies targeting FSP1. To unravel this puzzle, we purified human (hFSP1) using baculovirus eukaryotic expression system solved at resolution 1.75 Å. Furthermore, evaluated oxidoreductase activity hFSP1 with NADH as substrate identified E156 key amino acid maintaining activity. Interestingly, our results indicated exists functions monomeric state. Mutagenesis analysis revealed critical C-terminal domain binding substrate. These findings significantly enhance understanding functional mechanism provide precise model further drug development.

Язык: Английский

Процитировано

5