IL-6 Promotes Muscle Atrophy by Increasing Ubiquitin–Proteasome Degradation of Muscle Regeneration Factors After Cerebral Infarction in Rats

NeuroMolecular Medicine, Год журнала: 2025, Номер 27(1)

Опубликована: Янв. 3, 2025

Язык: Английский

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Butylphthalide may inhibit blood–brain barrier disruption through complement-related pathways to alleviate cognitive impairment in epileptic mice

Epilepsy & Behavior, Год журнала: 2025, Номер 164, С. 110251 - 110251

Опубликована: Янв. 18, 2025

Язык: Английский

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Investigation of the Impact Factors and Efficacy of N-Butylphthalide (NBP) on Functional Outcomes Following Mechanical Thrombectomy in Stroke Patients

International Journal of General Medicine, Год журнала: 2025, Номер Volume 18, С. 1311 - 1324

Опубликована: Март 1, 2025

Ischemic stroke was a major cause of mortality and disability worldwide. Mechanical thrombectomy (MT) has improved acute ischemic treatment by restoring blood flow in large vessel occlusions. Yet, reperfusion injury remains challenge, necessitating adjunctive neuroprotective strategies to enhance recovery. N-butylphthalide (NBP), with its anti-inflammatory antioxidative properties, may improve functional outcomes post-MT. This retrospective study analyzed 120 patients treated MT at single institution from December 2020 2022. Patients were divided into routine care group (n = 56) an NBP 64). Baseline characteristics, comorbidities, biochemical profiles assessed. Functional measured the modified Rankin Scale (mRS) 90 days. Statistical analysis included correlation logistic regression identify factors influencing Among group, significantly higher percentage achieved favorable mRS scores (0-2) compared (62.50% vs 37.50%, P 0.006). Smoking (OR 0.320, 0.021), diabetes 0.246, 0.022), elevated hs-CRP levels 0.407, 0.004) identified as negative predictors Conversely, 3.248, 0.008). The supports potential effective therapy improving recovery following patients. Modifiable such smoking diabetes, along hs-CRP, negatively influence outcomes, highlighting importance comprehensive management.

Язык: Английский

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PANoptosis: a potential target of atherosclerotic cardiovascular disease

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

PANoptosis is a newly discovered cell death pathway triggered by the innate immunizer, which in turn promotes assembly of PANoptosome and activates downstream effectors. As special mode, it characterized apoptosis, pyroptosis, necroptosis at same time; therefore, not feasible to inhibit suppressing single pathway. However, active ingredients targeting can effectively PANoptosis.Given importance disease, would be an important therapeutic tool. Previous studies have focused more on infectious diseases cancer, role cardiovascular field has been comprehensively addressed. While ASCVD number one killer diseases, explore new targets determine future research directions. Therefore, this review focuses PANoptosome, molecular mechanism PANoptosis, related mechanisms leading such as myocardial infarction, ischemic cardiomyopathy stroke, order provide perspective for prevention treatment ASCVD.

Язык: Английский

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The emerging role of PANoptosis in viral infections disease

Cellular Signalling, Год журнала: 2024, Номер 125, С. 111497 - 111497

Опубликована: Ноя. 1, 2024

Язык: Английский

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Synthesis and biological evaluation of novel isobenzofuran-1(3H)-one derivatives as antidepressant agents

Bioorganic & Medicinal Chemistry, Год журнала: 2024, Номер 114, С. 117941 - 117941

Опубликована: Окт. 17, 2024

Язык: Английский

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