IL-6 Promotes Muscle Atrophy by Increasing Ubiquitin–Proteasome Degradation of Muscle Regeneration Factors After Cerebral Infarction in Rats

NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: Jan. 3, 2025

Language: Английский

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Butylphthalide may inhibit blood–brain barrier disruption through complement-related pathways to alleviate cognitive impairment in epileptic mice

Epilepsy & Behavior, Journal Year: 2025, Volume and Issue: 164, P. 110251 - 110251

Published: Jan. 18, 2025

Language: Английский

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Investigation of the Impact Factors and Efficacy of N-Butylphthalide (NBP) on Functional Outcomes Following Mechanical Thrombectomy in Stroke Patients

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 1311 - 1324

Published: March 1, 2025

Ischemic stroke was a major cause of mortality and disability worldwide. Mechanical thrombectomy (MT) has improved acute ischemic treatment by restoring blood flow in large vessel occlusions. Yet, reperfusion injury remains challenge, necessitating adjunctive neuroprotective strategies to enhance recovery. N-butylphthalide (NBP), with its anti-inflammatory antioxidative properties, may improve functional outcomes post-MT. This retrospective study analyzed 120 patients treated MT at single institution from December 2020 2022. Patients were divided into routine care group (n = 56) an NBP 64). Baseline characteristics, comorbidities, biochemical profiles assessed. Functional measured the modified Rankin Scale (mRS) 90 days. Statistical analysis included correlation logistic regression identify factors influencing Among group, significantly higher percentage achieved favorable mRS scores (0-2) compared (62.50% vs 37.50%, P 0.006). Smoking (OR 0.320, 0.021), diabetes 0.246, 0.022), elevated hs-CRP levels 0.407, 0.004) identified as negative predictors Conversely, 3.248, 0.008). The supports potential effective therapy improving recovery following patients. Modifiable such smoking diabetes, along hs-CRP, negatively influence outcomes, highlighting importance comprehensive management.

Language: Английский

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PANoptosis: a potential target of atherosclerotic cardiovascular disease

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

PANoptosis is a newly discovered cell death pathway triggered by the innate immunizer, which in turn promotes assembly of PANoptosome and activates downstream effectors. As special mode, it characterized apoptosis, pyroptosis, necroptosis at same time; therefore, not feasible to inhibit suppressing single pathway. However, active ingredients targeting can effectively PANoptosis.Given importance disease, would be an important therapeutic tool. Previous studies have focused more on infectious diseases cancer, role cardiovascular field has been comprehensively addressed. While ASCVD number one killer diseases, explore new targets determine future research directions. Therefore, this review focuses PANoptosome, molecular mechanism PANoptosis, related mechanisms leading such as myocardial infarction, ischemic cardiomyopathy stroke, order provide perspective for prevention treatment ASCVD.

Language: Английский

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The emerging role of PANoptosis in viral infections disease

Cellular Signalling, Journal Year: 2024, Volume and Issue: 125, P. 111497 - 111497

Published: Nov. 1, 2024

Language: Английский

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Synthesis and biological evaluation of novel isobenzofuran-1(3H)-one derivatives as antidepressant agents

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 114, P. 117941 - 117941

Published: Oct. 17, 2024

Language: Английский

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