Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence
Metabolites,
Год журнала:
2025,
Номер
15(2), С. 124 - 124
Опубликована: Фев. 13, 2025
Neurodegenerative
diseases
comprise
a
group
of
chronic,
usually
age-related,
disorders
characterized
by
progressive
neuronal
loss,
deformation
structure,
or
loss
function,
leading
to
substantially
reduced
quality
life.
They
remain
significant
focus
scientific
and
clinical
interest
due
their
increasing
medical
social
importance.
Most
neurodegenerative
present
intracellular
protein
aggregation
extracellular
deposition
(plaques),
such
as
α-synuclein
in
Parkinson's
disease
amyloid
beta
(Aβ)/tau
aggregates
Alzheimer's.
Conventional
treatments
for
conditions
incur
high
costs
are
related
the
development
several
adverse
effects.
In
addition,
many
patients
irresponsive
them.
For
these
reasons,
there
is
growing
tendency
find
new
therapeutic
approaches
help
patients.
This
review
intends
investigate
some
phytocompounds'
effects
on
diseases.
These
generally
increased
oxidative
stress
inflammation,
so
phytocompounds
can
prevent
treat
To
achieve
our
aim
provide
critical
assessment
current
literature
about
phytochemicals
targeting
neurodegeneration,
we
reviewed
reputable
databases,
including
PubMed,
EMBASE,
COCHRANE,
seeking
trials
that
utilized
against
conditions.
A
few
investigated
humans,
after
screening,
13
were
ultimately
included
following
PRISMA
guidelines.
compounds
include
polyphenols
(flavonoids
luteolin
quercetin,
phenolic
acids
rosmarinic
acid,
ferulic
caffeic
other
like
resveratrol),
alkaloids
(such
berberine,
huperzine
A,
caffeine),
terpenoids
ginkgolides
limonene).
The
gathered
evidence
underscores
caffeine,
ginkgolides,
primarily
anti-inflammatory,
antioxidant,
neuroprotective,
counteracting
neuroinflammation,
oxidation,
synaptic
dysfunctions,
which
crucial
aspects
intervention
various
conditions,
Alzheimer's
dementias,
depression,
neuropsychiatric
disorders.
summary,
they
show
use
improvements
cognition,
memory,
disinhibition,
irritability/lability,
aberrant
behavior,
hallucinations,
mood
Язык: Английский
The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 138 - 138
Опубликована: Янв. 22, 2025
Background:
Cellular
senescence
is
a
biological
process
with
dual
role
in
organismal
health.
While
transient
supports
tissue
repair
and
acts
as
tumor-suppressive
mechanism,
the
chronic
accumulation
of
senescent
cells
contributes
to
aging
progression
age-related
diseases.
Senotherapeutics,
including
senolytics,
which
selectively
eliminate
cells,
senomorphics,
modulate
senescence-associated
secretory
phenotype
(SASP),
have
emerged
promising
strategies
for
managing
pathologies.
Among
these,
polyphenols,
diverse
group
plant-derived
bioactive
compounds,
gained
attention
their
potential
cellular
senescence.
Methods:
This
review
synthesizes
evidence
from
vitro,
vivo,
clinical
studies
on
senolytic
senomorphic
activities
resveratrol,
kaempferol,
apigenin,
fisetin.
The
analysis
focuses
molecular
mechanisms
action
impact
fundamental
aging-related
pathways.
Results:
Polyphenols
exhibit
therapeutic
versatility
by
activating
SIRT1,
inhibiting
NF-κB,
modulating
autophagy.
These
compounds
demonstrate
role,
promoting
survival
healthy
while
inducing
apoptosis
cells.
Preclinical
indicates
capacity
reduce
SASP-associated
inflammation,
restore
homeostasis,
attenuate
various
models
aging.
Conclusions:
represent
class
senotherapeutics
mitigating
diseases
lifespan
extension.
Further
research
should
focus
validation
long-term
effects
these
paving
way
development
agents
geriatric
medicine.
Язык: Английский
Revealing the anti-senescence effects and related mechanisms of flavonoid extracts from the buds of Wikstroemia chamaedaphne Meisn on D-galactose-induced PC12 cells based on network pharmacology and transcriptomics
Future Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
11(1)
Опубликована: Март 10, 2025
Abstract
Background
Natural
products
are
an
important
source
of
drugs
or
lead
compounds
for
the
treatment
senescence.
The
buds
Wikstroemia
chamaedaphne
Meisn
a
traditional
Chinese
medicine
to
cure
edema,
schizophrenia
and
epilepsy.
A
flavonoid
extract
W.
(FEW)
was
prepared
from
methanolic
by
our
group
previously,
which
including
eight
flavonoids
with
content
(55.19
±
0.32)
%.
In
this
study,
anti-senescence
effects
related
mechanisms
FEW
on
D-galactose-induced
PC12
cells
were
investigated
first
time.
Results
High
doses
D-galactose
could
induce
cell
senescence,
whereas
delay
senescence
decreasing
SA-β-gal
positivity,
increasing
SOD
activity,
reducing
MDA
levels,
improving
morphology,
inhibiting
cycle
arrest
down-regulating
expression
senescence-related
proteins
P16,
P21
P53.
Subsequently,
potential
underlying
elucidated
through
integration
network
pharmacology
transcriptomics.
main
signaling
pathways
involved
found
be
cancer
pathway,
FOXO
PI3k–Akt
AGE–RAGE
protein
digestion
uptake,
etc.
may
pathway
as
revealed
western
blot
experiments.
Conclusion
Our
study
that
has
effects.
This
suggest
acts
agent
age-related
neurological
diseases.
Язык: Английский
Hippocampal microRNA-181a overexpression participates in anxiety and ethanol related behaviors via regulating the expression of SIRT-1
Physiology & Behavior,
Год журнала:
2025,
Номер
unknown, С. 114839 - 114839
Опубликована: Фев. 1, 2025
Язык: Английский
Luteolin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity through activation of Nrf2/Keap1 signaling
Ryo Hayakawa,
Takeshi Ishii,
Taiki Fushimi
и другие.
Free Radical Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Май 9, 2025
Age-related
macular
degeneration
(AMD),
a
serious
physical
and
mental
health
problem
worldwide,
is
the
leading
cause
of
irreversible,
severe
vision
impairment
loss
in
older
people.
AMD
associated
with
multiple
risk
factors,
many
which
are
closely
linked
to
increased
oxidative
stress.
Some
studies
have
suggested
that
long-term
excessive
exposure
blue
light
may
be
potential
factor
for
development
or
progression
AMD.
Recently,
we
demonstrated
irradiation
caused
stress
all-trans-retinal
(atRAL)-exposed
human
ARPE-19
retinal
pigment
epithelium
cells
by
generating
singlet
oxygen
(1O2),
apoptotic
cell
death.
Luteolin,
flavonoid
found
various
edible
plants,
has
been
reported
possess
divergent
health-promoting
properties
including
anti-oxidative
chemopreventive
effects
up-regulating
phase
II
detoxifying
enzymes
through
activation
Keap1/Nrf2
signaling.
Herein,
verified
cytoprotective
action
luteolin
against
using
atRAL-exposed
cells.
Our
results
established
effectively
prevented
light-induced
apoptosis
mitigating
We
also
confirmed
suppressed
intracellular
accumulation
1O2
formation
atRAL-derived
lipofuscin
expression
heme
oxygenase-1
aldehyde
dehydrogenase
1A1
Furthermore,
our
data
implied
luteolin-provoked
signaling
might
due
covalent
binding
o-quinone
critical
cysteinyl
thiol
Keap1.
The
present
suggest
could
helpful
prevention
amelioration
degeneration,
Язык: Английский
The Antiaging Potential of Dietary Plant-Based Polyphenols: A Review on Their Role in Cellular Senescence Modulation
Nutrients,
Год журнала:
2025,
Номер
17(10), С. 1716 - 1716
Опубликована: Май 19, 2025
Aging
is
a
complex
biological
process
characterized
by
progressive
decline
in
physiological
functions
and
an
increased
risk
of
chronic
diseases.
A
key
mechanism
this
cellular
senescence,
the
permanent
arrest
cell
cycle
response
to
stress
or
damage,
which
contributes
accumulation
dysfunctional
cells
tissues.
Recent
research
has
highlighted
role
polyphenols,
bioactive
compounds
present
numerous
plant-based
foods,
positively
modulating
these
processes.
Polyphenols
exert
antioxidant
effects,
regulate
gene
expression
improve
mitochondrial
function,
helping
delay
aging
prevent
age-related
In
addition,
some
polyphenols
exhibit
senolytic
properties,
selectively
eliminating
senescent
promoting
tissue
regeneration.
This
review
summarizes
current
evidence
on
effects
exploring
underlying
molecular
mechanisms
discussing
their
potential
nutritional
strategies
aimed
at
healthy
aging.
Язык: Английский
Deregulation of Neuroinflammatory and Neurotrophic Factors as Biological Events Triggered by D-Galactose Chronic Administration in Wistar Rats
NeuroMolecular Medicine,
Год журнала:
2025,
Номер
27(1)
Опубликована: Май 21, 2025
Язык: Английский
Protective Effect of FABP5 Against 6-OHDA Induced Parkinson’s Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway
Neurochemical Research,
Год журнала:
2025,
Номер
50(3)
Опубликована: Май 30, 2025
Язык: Английский
Neuroprotective effects of trigonelline in eggplant on oxidative damage of PC12 cells and cognitive impairment in aging mice
Journal of Functional Foods,
Год журнала:
2024,
Номер
121, С. 106441 - 106441
Опубликована: Сен. 11, 2024
Язык: Английский
Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways
World Journal of Cardiology,
Год журнала:
2024,
Номер
16(11), С. 632 - 643
Опубликована: Окт. 30, 2024
As
a
non-communicable
disease,
cardiovascular
disorders
have
become
the
leading
cause
of
death
for
men
and
women.
Of
additional
concern
is
that
disease
linked
to
chronic
comorbidity
include
nonalcoholic
fatty
liver
(NAFLD).
NAFLD,
also
termed
metabolic-dysfunction-associated
steatotic
greatest
throughout
world,
increasing
in
prevalence
concurrently
with
diabetes
mellitus
(DM),
can
progress
steatohepatitis
leads
cirrhosis
fibrosis.
Individuals
metabolic
disorders,
such
as
DM,
are
more
than
two
times
likely
experience
cardiac
stroke,
includes
NAFLD
when
compared
individuals
without
disorders.
Interestingly,
share
common
underlying
cellular
mechanism
pathology,
namely
silent
mating
type
information
regulation
2
homolog
1
(SIRT1;
Язык: Английский