Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways DOI Open Access
Kenneth Maiese

World Journal of Cardiology, Journal Year: 2024, Volume and Issue: 16(11), P. 632 - 643

Published: Oct. 30, 2024

As a non-communicable disease, cardiovascular disorders have become the leading cause of death for men and women. Of additional concern is that disease linked to chronic comorbidity include nonalcoholic fatty liver (NAFLD). NAFLD, also termed metabolic-dysfunction-associated steatotic greatest throughout world, increasing in prevalence concurrently with diabetes mellitus (DM), can progress steatohepatitis leads cirrhosis fibrosis. Individuals metabolic disorders, such as DM, are more than two times likely experience cardiac stroke, includes NAFLD when compared individuals without disorders. Interestingly, share common underlying cellular mechanism pathology, namely silent mating type information regulation 2 homolog 1 (SIRT1;

Language: Английский

Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence DOI Creative Commons
Enzo Pereira de Lima, Lucas Fornari Laurindo,

Vitor Cavallari Strozze Catharin

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 124 - 124

Published: Feb. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Language: Английский

Citations

6
Hippocampal microRNA-181a overexpression participates in anxiety and ethanol related behaviors via regulating the expression of SIRT-1 DOI
Amine Bahí

Physiology & Behavior, Journal Year: 2025, Volume and Issue: unknown, P. 114839 - 114839

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action DOI Creative Commons
Larissa Della Vedova, Giovanna Baron,

Paolo Morazzoni

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 138 - 138

Published: Jan. 22, 2025

Background: Cellular senescence is a biological process with dual role in organismal health. While transient supports tissue repair and acts as tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging progression age-related diseases. Senotherapeutics, including senolytics, which selectively eliminate cells, senomorphics, modulate senescence-associated secretory phenotype (SASP), have emerged promising strategies for managing pathologies. Among these, polyphenols, diverse group plant-derived bioactive compounds, gained attention their potential cellular senescence. Methods: This review synthesizes evidence from vitro, vivo, clinical studies on senolytic senomorphic activities resveratrol, kaempferol, apigenin, fisetin. The analysis focuses molecular mechanisms action impact fundamental aging-related pathways. Results: Polyphenols exhibit therapeutic versatility by activating SIRT1, inhibiting NF-κB, modulating autophagy. These compounds demonstrate role, promoting survival healthy while inducing apoptosis cells. Preclinical indicates capacity reduce SASP-associated inflammation, restore homeostasis, attenuate various models aging. Conclusions: represent class senotherapeutics mitigating diseases lifespan extension. Further research should focus validation long-term effects these paving way development agents geriatric medicine.

Language: Английский

Citations

0
Revealing the anti-senescence effects and related mechanisms of flavonoid extracts from the buds of Wikstroemia chamaedaphne Meisn on D-galactose-induced PC12 cells based on network pharmacology and transcriptomics DOI Creative Commons
Xiu-Ying Zhao,

Wen-Qian Liu,

Liwei Zhang

et al.

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 10, 2025

Abstract Background Natural products are an important source of drugs or lead compounds for the treatment senescence. The buds Wikstroemia chamaedaphne Meisn a traditional Chinese medicine to cure edema, schizophrenia and epilepsy. A flavonoid extract W. (FEW) was prepared from methanolic by our group previously, which including eight flavonoids with content (55.19 ± 0.32) %. In this study, anti-senescence effects related mechanisms FEW on D-galactose-induced PC12 cells were investigated first time. Results High doses D-galactose could induce cell senescence, whereas delay senescence decreasing SA-β-gal positivity, increasing SOD activity, reducing MDA levels, improving morphology, inhibiting cycle arrest down-regulating expression senescence-related proteins P16, P21 P53. Subsequently, potential underlying elucidated through integration network pharmacology transcriptomics. main signaling pathways involved found be cancer pathway, FOXO PI3k–Akt AGE–RAGE protein digestion uptake, etc. may pathway as revealed western blot experiments. Conclusion Our study that has effects. This suggest acts agent age-related neurological diseases.

Language: Английский

Citations

0
Luteolin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity through activation of Nrf2/Keap1 signaling DOI

Ryo Hayakawa,

Takeshi Ishii,

Taiki Fushimi

et al.

Free Radical Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: May 9, 2025

Age-related macular degeneration (AMD), a serious physical and mental health problem worldwide, is the leading cause of irreversible, severe vision impairment loss in older people. AMD associated with multiple risk factors, many which are closely linked to increased oxidative stress. Some studies have suggested that long-term excessive exposure blue light may be potential factor for development or progression AMD. Recently, we demonstrated irradiation caused stress all-trans-retinal (atRAL)-exposed human ARPE-19 retinal pigment epithelium cells by generating singlet oxygen (1O2), apoptotic cell death. Luteolin, flavonoid found various edible plants, has been reported possess divergent health-promoting properties including anti-oxidative chemopreventive effects up-regulating phase II detoxifying enzymes through activation Keap1/Nrf2 signaling. Herein, verified cytoprotective action luteolin against using atRAL-exposed cells. Our results established effectively prevented light-induced apoptosis mitigating We also confirmed suppressed intracellular accumulation 1O2 formation atRAL-derived lipofuscin expression heme oxygenase-1 aldehyde dehydrogenase 1A1 Furthermore, our data implied luteolin-provoked signaling might due covalent binding o-quinone critical cysteinyl thiol Keap1. The present suggest could helpful prevention amelioration degeneration,

Language: Английский

Citations

0
Neuroprotective effects of trigonelline in eggplant on oxidative damage of PC12 cells and cognitive impairment in aging mice DOI Creative Commons

Jiahui Feng,

Weihua Liu,

Danqi Feng

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 121, P. 106441 - 106441

Published: Sept. 11, 2024

Language: Английский

Citations

1
Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways DOI Open Access
Kenneth Maiese

World Journal of Cardiology, Journal Year: 2024, Volume and Issue: 16(11), P. 632 - 643

Published: Oct. 30, 2024

As a non-communicable disease, cardiovascular disorders have become the leading cause of death for men and women. Of additional concern is that disease linked to chronic comorbidity include nonalcoholic fatty liver (NAFLD). NAFLD, also termed metabolic-dysfunction-associated steatotic greatest throughout world, increasing in prevalence concurrently with diabetes mellitus (DM), can progress steatohepatitis leads cirrhosis fibrosis. Individuals metabolic disorders, such as DM, are more than two times likely experience cardiac stroke, includes NAFLD when compared individuals without disorders. Interestingly, share common underlying cellular mechanism pathology, namely silent mating type information regulation 2 homolog 1 (SIRT1;

Language: Английский

Citations

0