International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(9), С. 4692 - 4692
Опубликована: Апрель 25, 2024
In
drug
discovery,
selecting
targeted
molecules
is
crucial
as
the
target
could
directly
affect
efficacy
and
treatment
outcomes.
As
a
member
of
CCN
family,
CTGF
(also
known
CCN2)
an
essential
regulator
in
progression
various
diseases,
including
fibrosis,
cancer,
neurological
disorders,
eye
diseases.
Understanding
regulatory
mechanisms
different
diseases
may
contribute
to
discovery
novel
candidates.
Summarizing
CTGF-targeting
-inhibitory
drugs
also
beneficial
for
analysis
efficacy,
applications,
limitations
these
disease
models.
Therefore,
we
reviewed
structure,
development
order
provide
more
references
future
discovery.
Antibiotics,
Год журнала:
2024,
Номер
13(4), С. 342 - 342
Опубликована: Апрель 9, 2024
To
evaluate
the
in
vitro
antimicrobial
and
antibiofilm
properties
immune
modulatory
activity
of
cannabidiol
(CBD)
cannabigerol
(CBG)
on
oral
bacteria
periodontal
ligament
fibroblasts
(PLF).
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Май 27, 2022
Since
viral
infectious
diseases
continue
to
be
a
global
health
threat,
new
antiviral
drugs
are
urgently
needed.
A
unique
class
of
therapeutic
compounds
antimicrobial
peptides
(AMPs).
They
can
found
in
humans,
bacteria
and
plants.
Plants
express
wide
variety
such
defense
as
part
their
innate
immune
system
protect
from
invading
pathogens.
Cyclotides
non-classical
AMPs
that
share
similar
structure.
Their
topology
consists
circular
peptide
backbone
disulfide
bonds.
In
previous
studies
they
have
been
attributed
range
biological
activities.
To
identify
novel
cyclotides
with
activity,
we
established
library
plant
extracts
largely
consisting
cyclotide-rich
species
screened
them
inhibitors
HIV-1
infection.
Subsequent
extraction
fractionation
revealed
four
cyclotide-containing
subfractions
Viola
tricolor
activity.
These
inhibited
infection
IC50
values
between
0.6
11.2
μg/ml,
selectivity
indices
up
8.1.
The
identification
characterization
the
determination
mechanisms
may
allow
develop
agents
combat
infections.
Therefore,
represent
natural
source
bioactive
molecules
prospects
for
development
therapeutics.
Membranes,
Год журнала:
2024,
Номер
14(2), С. 36 - 36
Опубликована: Янв. 29, 2024
The
development
of
efficient,
eco-friendly
antimicrobial
agents
for
air
purification
and
disinfection
addresses
public
health
issues
connected
to
preventing
airborne
pathogens.
Herein,
the
activity
a
nanoemulsion
(control,
5%,
10%,
15%)
containing
neem
lavender
oils
with
polycaprolactone
(PCL)
was
investigated
against
bacteria,
including
Escherichia
coli,
Bacillus
subtilis,
Staphylococcus
aureus.
Various
parameters
such
as
physicochemical
properties
nanoemulsion,
pH,
droplet
size,
polydispersity
index
(PDI),
minimum
inhibitory
concentration
(MIC),
bacterial
(MBC),
color
measurement
emulsion
have
been
evaluated
optimized.
Our
results
showed
that
PCL
combined
oil
found
be
highest
MIC
MBC
all
tested
bacteria.
sizes
are
21.86–115.15
nm,
23.92–119.15
their
combination
is
25.97–50.22
nm.
range
pH
viscosity
nanoemulsions
various
concentrations
5.8
6.6
0.372
2.101
cP.
This
study
highlights
potential
nanotechnology
in
harnessing
natural
essential
oils,
paving
way
innovative
sustainable
solutions
fight
contamination.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(9), С. 4692 - 4692
Опубликована: Апрель 25, 2024
In
drug
discovery,
selecting
targeted
molecules
is
crucial
as
the
target
could
directly
affect
efficacy
and
treatment
outcomes.
As
a
member
of
CCN
family,
CTGF
(also
known
CCN2)
an
essential
regulator
in
progression
various
diseases,
including
fibrosis,
cancer,
neurological
disorders,
eye
diseases.
Understanding
regulatory
mechanisms
different
diseases
may
contribute
to
discovery
novel
candidates.
Summarizing
CTGF-targeting
-inhibitory
drugs
also
beneficial
for
analysis
efficacy,
applications,
limitations
these
disease
models.
Therefore,
we
reviewed
structure,
development
order
provide
more
references
future
discovery.
