Advanced Therapeutics,
Год журнала:
2024,
Номер
7(8)
Опубликована: Июль 14, 2024
Abstract
The
design
of
biologic
and
synthetic
drugs
in
the
pharmaceutical
industry
is
facing
three
key
challenges,
namely,
ensuring
bioavailability,
solubility,
stability.
Ionic
liquids
(ILs)
deep
eutectic
solvents
(DESs),
classified
as
designer
solvents,
have
emerged
excellent
for
improving
permeability
stability
biotherapeutic
drugs.
Moreover,
they
shown
remarkable
solubilizing
effects
drugs,
particularly
active
ingredients
(API),
are
known
eco‐friendly
solvents.
Thus,
this
review,
development
formulations
industries
reported,
underlying
strategies
designing
most
efficient
both
biotherapeutics
examined.
RSC Sustainability,
Год журнала:
2024,
Номер
2(6), С. 1809 - 1818
Опубликована: Янв. 1, 2024
Phenolic
polymeric
deep
eutectic
solvents
form
coloured
complexes
with
iron
surfaces
which
can
be
used
as
protection
coatings
for
corrosion
control
of
mild
steel.
Polymers,
Год журнала:
2023,
Номер
15(5), С. 1076 - 1076
Опубликована: Фев. 21, 2023
There
is
an
actual
need
for
developing
materials
wound
healing
applications
with
anti-inflammatory,
antioxidant,
or
antibacterial
properties
in
order
to
improve
the
performance.
In
this
work,
we
report
preparation
and
characterization
of
soft
bioactive
iongel
patches,
based
on
polymeric
poly(vinyl
alcohol)
(PVA)
four
ionic
liquids
containing
cholinium
cation
different
phenolic
acid
anions,
namely
salicylate
([Ch][Sal]),
gallate
([Ch][Ga]),
vanillate
([Ch][Van]),
caffeate
([Ch][Caff]).
Within
iongels,
motif
plays
a
dual
role,
acting
as
PVA
crosslinker
compound.
The
obtained
iongels
are
flexible,
elastic,
conducting,
thermoreversible
materials.
Moreover,
demonstrated
high
biocompatibility,
non-hemolytic
activity,
non-agglutination
mice
blood,
which
key-sought
material
specifications
applications.
All
have
shown
properties,
being
PVA-[Ch][Sal],
one
higher
inhibition
halo
Escherichia
Coli.
also
revealed
values
antioxidant
activity
due
presence
polyphenol,
PVA-[Ch][Van]
having
highest
activity.
Finally,
show
decrease
NO
production
LPS-stimulated
macrophages,
PVA-[Ch][Sal]
displaying
best
anti-inflammatory
(>63%
at
200
µg/mL).
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 198 - 198
Опубликована: Янв. 30, 2024
Previously
obtained
amphiphilic
graft
copolymers
based
on
[2-(methacryloyloxy)ethyl]trimethylammonium
chloride
(TMAMA)
ionic
liquid
were
used
as
the
matrices
of
three
types
nanocarriers,
i.e.,
conjugates
with
piperacillin
(PIP)
and
micelles
tazobactam
(TAZ),
which
represented
single
systems,
dual
systems
bearing
PIP
anions
encapsulated
TAZ
for
co-delivery.
The
exchange
Cl
in
TMAMA
units
ones
resulted
a
yield
45.6–72.7
mol.%.
self-assembling
properties
confirmed
by
critical
micelle
concentration
(CMC),
which,
after
ion
exchange,
increased
significantly
(from
0.011–0.020
mg/mL
to
0.041–0.073
mg/mL).
beneficial
encapsulation
reach
drug
loading
contents
(DLCs)
ranges
37.2–69.5
mol.%
50.4–80.4
form
particles
sizes
97–319
nm
24–192
respectively.
In
vitro
studies
indicated
that
ionically
conjugated
was
released
quantities
66–81%
(7.8–15.0
μg/mL)
from
single-drug
21–25%
(2.6–3.9
dual-drug
systems.
release
more
efficient,
achieving
47–98%
(7.5–9.0
47–69%
(9.6–10.4
ones.
Basic
cytotoxicity
showed
non-toxicity
polymer
matrices,
while
introduction
selected
drugs
induced
against
normal
human
bronchial
epithelial
cells
(BEAS-2B)
increase
concentration.
Advanced Therapeutics,
Год журнала:
2024,
Номер
7(8)
Опубликована: Июль 14, 2024
Abstract
The
design
of
biologic
and
synthetic
drugs
in
the
pharmaceutical
industry
is
facing
three
key
challenges,
namely,
ensuring
bioavailability,
solubility,
stability.
Ionic
liquids
(ILs)
deep
eutectic
solvents
(DESs),
classified
as
designer
solvents,
have
emerged
excellent
for
improving
permeability
stability
biotherapeutic
drugs.
Moreover,
they
shown
remarkable
solubilizing
effects
drugs,
particularly
active
ingredients
(API),
are
known
eco‐friendly
solvents.
Thus,
this
review,
development
formulations
industries
reported,
underlying
strategies
designing
most
efficient
both
biotherapeutics
examined.
