Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 118897 - 118897
Опубликована: Окт. 1, 2024
Язык: Английский
Phytochemistry Letters, Год журнала: 2025, Номер 68, С. 102972 - 102972
Опубликована: Май 9, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2023, Номер 28(23), С. 7763 - 7763
Опубликована: Ноя. 24, 2023
Melanoma is one of the most dangerous forms skin cancer, characterized by early metastasis and rapid development. In search for effective treatment options, much attention given to triterpenoids plant origin, which are considered promising drug candidates due their well described anticancer properties relatively low toxicity. This paper comprehensively summarizes antimelanoma potential natural triterpenoids, that also used as scaffolds development more derivatives. These include betulin, betulinic acid, ursolic maslinic oleanolic celastrol lupeol. Some lesser-known deserve in this context 22β-hydroxytingenone, cucurbitacins, geoditin A ganoderic acids. Recently mechanisms action presented, together with results preclinical vitro vivo studies, use delivery systems pharmaceutical technologies improve bioavailability triterpenoids. reviews structural modifications, based on structure–activity observations. conclusion, origin some semi-synthetic derivatives exert significant cytotoxic, antiproliferative chemopreventive effects can be beneficial melanoma treatment. Recent data indicate poor solubility water, thus bioavailability, overcome complexing cyclodextrins, or nanoparticles ethosomes, making these compounds further
Язык: Английский
Процитировано
8
ACS Omega, Год журнала: 2023, Номер 8(33), С. 30630 - 30639
Опубликована: Авг. 8, 2023
Phytochemical study of the ethyl acetate root extract Zygophyllum album has resulted in isolation a new saponin, Zygo-albuside D (1), along with two known compounds; (3-O-[β-D-quinovopyranosyl]-quinovic acid) (2), which is first reported root, and catechin (3), genus. Their chemical structures were established by NMR high-resolution mass spectrometry (HRMS). The saponin (1) exhibited promising cytotoxicity IC50 values 3.5 5.52 μM on A549 PC-3 cancer cell lines, respectively, compared to doxorubicin 9.44 11.39 respectively. While it had an value 46.8 against WISH cells. Investigating apoptosis-induction, compound 1 induced total apoptotic death lung cells 32-fold; 21.53% 0.67% untreated control Finally, upregulated pro-apoptotic genes downregulated antiapoptotic gene using expression levels. Compound remarkable CDK-2 target inhibition 96.2% 117.6 nM Roscovitine. molecular docking further confirmed binding affinity as CDK2 Bcl2 inhibitors that led apoptosis induction Hence, this highlights importance design anticancer agent specific mechanisms.
Язык: Английский
Процитировано
6
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 197, С. 114234 - 114234
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
2
Molecules, Год журнала: 2024, Номер 29(16), С. 3794 - 3794
Опубликована: Авг. 10, 2024
Plants from the Amaranthaceae family are a source of oleanolic acid (OA)-type saponins with cytotoxic activity. Two known OA-type saponins, calenduloside E and chikusetsusaponin IVa, were isolated roots Chenopodium strictum Roth. Their structures confirmed using MS NMR techniques. This constitutes inaugural report in Ch. strictum. Both structurally similar compounds, momordin Ic OA, compared for their cytotoxicity against various cancer normal cell lines (including skin, breast, thyroid, gastrointestinal, prostate panels). effects dose- time-dependent, varying specific line compound structure. A chemometric approach demonstrated compounds on lines. The study discusses structure–activity observations. key structural elements potent activity included free carboxyl group 28COOH sapogenin structure (OA) presence sugar moiety. monodesmosides glucuronic (GlcA) at C3 position OA generally more than bidesmosides or alone. addition xylose chain modified towards cells depending line. GlcA (particularly Ic) represent promising avenue further investigation as potential anticancer agents.
Язык: Английский
Процитировано
2
Current Computer - Aided Drug Design, Год журнала: 2024, Номер 21(1), С. 94 - 109
Опубликована: Фев. 4, 2024
Background: Uncaria tomentosa is a traditional medicinal herb renowned for its anti-inflammatory, antioxidant, and immune-enhancing properties. In the realm of neurodegenerative diseases (NDDS), CLASP proteins, responsible regulating microtubule dynamics in neurons, have emerged as critical players. Dysregulation proteins associated with NDDS, such Alzheimer's, Parkinson's, Huntington's diseases. Consequently, comprehending role NDDS holds promise development innovative therapeutic interventions. Objectives: The objectives research were to identify phytoconstituents hydroalcoholic extract (HEUT), evaluate antioxidant potential through vitro free radical scavenging assays explore interaction using silico molecular docking studies. Methods: HPLC LC-MS techniques used quantify phytochemicals HEUT. was assessed DPPH, ferric reducing power (FRAP), nitric oxide (NO) superoxide (SO) methods. Interactions between conventional quinovic acid, chlorogenic epicatechin, corynoxeine, rhynchophylline syringic acid studied Auto Dock 4.2. Results: HEUT demonstrated highest concentration derivatives. exhibited strong radical-scavenging activity IC50 values 0.113 μg/ml (DPPH) 9.51 μM (FRAP). It also suppressed NO production by 47.1 ± 0.37% at 40 inhibited 77.3 0.69% SO generation. Additionally, revealed NDDS. Conclusion: protein suggest promising treating linked dysregulation.
Язык: Английский
Процитировано
1
Microscopy Research and Technique, Год журнала: 2024, Номер 87(9), С. 2143 - 2153
Опубликована: Май 5, 2024
Abstract In the Medicago genus, saponins are complex mixtures of triterpene pentacyclic glycosides extensively studied for their different and economically relevant biological pharmaceutical properties. This research is aimed at determining first time tissue cellular localization in vegetative organs truncatula , a model plant species legumes, by histochemistry transmission electron microscopy. The results showed that present mainly palisade mesophyll layer leaves, whereas stems they mostly located primary phloem subepidermal cells cortical parenchyma. root tissue, occur secondary region. Transmission microscopy revealed prominent saponin accumulation within leaf stem chloroplasts, while roots found vesicular structures. Our demonstrate feasibility using to localize M. levels provide important information further studies on biosynthesis regulation valuable bioactive agronomic spp., such as alfalfa ( sativa L.). Research Highlights genus represents rich source saponins, one most interesting groups metabolites, which possess pharmacological Plant great importance better understand functions, biosynthetic pathway, regulatory mechanisms. We elucidate with histochemical studies.
Язык: Английский
Процитировано
1
Journal of Functional Foods, Год журнала: 2024, Номер 118, С. 106265 - 106265
Опубликована: Июнь 7, 2024
Язык: Английский
Процитировано
1
Studies in natural products chemistry, Год журнала: 2024, Номер unknown, С. 185 - 233
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Ноя. 8, 2024
This study aimed to investigate the effect of selected compounds from group triterpene sapogenins on model phosphatidylcholine membranes. Two types biological membrane systems were used in work, i.e., liposomes (microelectrophoresis method) and spherical bilayers (interfacial tension method). Each was modified with tested sapogenin compounds, change their physicochemical electrical parameters analyzed. Parameters characterizing equilibrium 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)-oleanolic acid (OA) DPPC-asiatic (AA) determined). Based Young-Laplace equation, interfacial tensions lipid measured. The formation 1:1 complexes assumed DPPC-OA DPPC-AA systems, interactions formed calculated. Microelectrophoresis surface charge density These values obtained electrophoretic mobility data using Smoluchowsky's equation. influence pH electrolyte solution composition membranes investigated. results indicate that modifying DPPC sapogenins, both OA AA, causes changes shifts isoelectric point. Data presented this through mathematical derivation confirmed experimentally, are great importance for interpreting phenomena occurring A quantitative description equilibria between lets us understand processes surface. particularly significant standpoint cell functioning. Phosphatidylcholine-sapogenin modulate a range properties membranes, they important course multiple involving living (e.g., transport mechanism).
Язык: Английский
Процитировано
1