Environmental Science and Pollution Research,
Год журнала:
2022,
Номер
29(22), С. 32631 - 32650
Опубликована: Фев. 24, 2022
Abstract
Bisphenol
A
(BPA)
is
one
of
the
most
widely
studied
endocrine
disrupting
chemicals
because
its
structural
similarity
to
17-β
estradiol;
ability
bind
as
an
agonist/antagonist
estrogen
receptors
elicits
adverse
effects
on
functioning
metabolic
and
endocrinal
system.
Therefore,
BPA
has
been
thoroughly
scrutinized
concerning
disruption
pathways
like
lipid
metabolism,
steroidogenesis,
insulin
signaling,
inflammation.
This
resulted
in
reports
correlation
with
various
aspects
cardiovascular
diseases,
obesity,
diabetes,
male
female
reproductive
disorders,
dysfunctions.
Among
these,
occurrence
polycystic
ovarian
syndrome
(PCOS)
premenopausal
women
great
concern.
PCOS
a
highly
prevalent
disorder
affecting
their
age
clinically
characterized
by
hyperandrogenism,
ovulatory
dysfunction,
morphology,
along
metabolism-related
dysfunctions
hyperinsulinemia,
resistance.
In
this
review,
we
analyzed
certain
researched
BPA,
while
focusing
alter
expression
significant
genes
GnRH
,
AdipoQ
ESR1
StAR
CYP11A1
CYP19A1
many
more
involved
regulation,
whose
commonly
associated
clinical
manifestations
PCOS.
Emerging contaminants,
Год журнала:
2022,
Номер
8, С. 162 - 194
Опубликована: Янв. 1, 2022
Emerging
contaminants
(ECs)
represent
a
small
fraction
of
the
large
chemical
pollution
puzzle
where
wide
variety
potentially
hazardous
chemicals
reach
environment,
and
new
compounds
are
continuously
synthesized
released
in
wastewater
treatment
plants
ultimately
effluent
biosolids.
ECs
have
been
classified
into
various
categories;
however,
this
article
focuses
on
fate
major
categories,
namely
pharmaceutical
personal
care
products
(PPCPs),
per-and
poly-fluoroalkyl
substances
(PFAS),
flame
retardants,
surfactants,
endocrine-disrupting
(EDCs),
microplastics
(MPs).
These
when
discharged
to
sewer
downstream
can
undergo
further
transformations
either
degrade,
persist
or
convert
by-products
which
potential
some
cases
be
more
hazardous.
Because
dangerous
impacts
availability
these
information
behavior
pollutants
is
highly
important
develop
strategies,
such
as
regulation
imported
Australia
Australian
consumer
goods
environmental
policies
mitigate
them
sustainable
way.
Moreover,
advanced
technologies
required
for
detection
identification
novel
emerging
environment
at
ultra
low
levels.
The
application
chromatographic
techniques
coupled
with
mass
spectroscopy
has
provided
attractive
breakthroughs
detect
contaminants.
However,
it
crucially
understand
sensitivity
robustness
analytical
dealing
complex
matrices
In
addition,
most
literature
was
focused
selected
family
existing
reviews
paid
less
attention
examine
formation
metabolites
during
process
their
ecosystem.
This
review
presents
an
overview
presence
different
classes
around
world,
quantification
from
sources
like
(influents
effluents),
sludge
transformation
process,
intermediate
also
critically
discussed.
Three
steps
analysis
include
sample
preparation,
extraction
clean-up,
analysis;
hence,
methods
employed
thoroughly
discussed,
advantages
limitations
highlighted.
comprehensive
believed
enhance
understanding
sewage
would
useful
readers
relevant
communities
stakeholders
investigate
maximize
destruction
ECs.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(19), С. 11899 - 11899
Опубликована: Окт. 7, 2022
Thousands
of
natural
or
manufactured
chemicals
were
defined
as
endocrine-disrupting
(EDCs)
because
they
can
interfere
with
hormone
activity
and
the
endocrine
system.
We
summarize
discuss
what
we
know
still
need
to
learn
about
EDCs'
pathogenic
mechanisms
action,
well
effects
most
common
EDCs
on
system
health
in
childhood.
The
MEDLINE
database
(PubMed)
was
searched
13
May
2022,
filtering
for
EDCs,
diseases,
children.
are
a
group
compounds
high
heterogeneity,
but
usually
disrupt
by
mimicking
interfering
hormones
body's
hormonal
balance
through
other
mechanisms.
Individual
studied
detail,
while
humans'
"cocktail
effect"
is
unclear.
In
utero,
early
postnatal
life,
and/or
pubertal
development
highly
susceptible
periods
exposure.
Human
epidemiological
studies
suggest
that
affect
prenatal
growth,
thyroid
function,
glucose
metabolism,
obesity,
puberty,
fertility
several
Further
needed
clarify
which
mainly
act
epigenetic
processes.
A
better
understanding
human
crucial
developing
future
regulatory
strategies
prevent
exposure
ensure
children
today,
generations,
environment.
Environmental Science and Pollution Research,
Год журнала:
2022,
Номер
29(22), С. 32631 - 32650
Опубликована: Фев. 24, 2022
Abstract
Bisphenol
A
(BPA)
is
one
of
the
most
widely
studied
endocrine
disrupting
chemicals
because
its
structural
similarity
to
17-β
estradiol;
ability
bind
as
an
agonist/antagonist
estrogen
receptors
elicits
adverse
effects
on
functioning
metabolic
and
endocrinal
system.
Therefore,
BPA
has
been
thoroughly
scrutinized
concerning
disruption
pathways
like
lipid
metabolism,
steroidogenesis,
insulin
signaling,
inflammation.
This
resulted
in
reports
correlation
with
various
aspects
cardiovascular
diseases,
obesity,
diabetes,
male
female
reproductive
disorders,
dysfunctions.
Among
these,
occurrence
polycystic
ovarian
syndrome
(PCOS)
premenopausal
women
great
concern.
PCOS
a
highly
prevalent
disorder
affecting
their
age
clinically
characterized
by
hyperandrogenism,
ovulatory
dysfunction,
morphology,
along
metabolism-related
dysfunctions
hyperinsulinemia,
resistance.
In
this
review,
we
analyzed
certain
researched
BPA,
while
focusing
alter
expression
significant
genes
GnRH
,
AdipoQ
ESR1
StAR
CYP11A1
CYP19A1
many
more
involved
regulation,
whose
commonly
associated
clinical
manifestations
PCOS.
