AVP deficiency (central diabetes insipidus) following immunization with anti-COVID-19 BNT162b2 Comirnaty vaccine in adolescents: A case report

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Апрель 18, 2023

The coronavirus disease 19 (COVID-19) pandemic has prompted the development of new vaccines to reduce morbidity and mortality associated with this disease. Recognition report potential adverse effects these novel (especially urgent life-threatening ones) is therefore essential.A 16-year-old boy presented Paediatric Emergency Department polyuria, polydipsia weight loss over last four months. His past medical history was unremarkable. Onset symptoms referred be few days after first dose anti-COVID-19 BNT162b2 Comirnaty vaccine then worsened second dose. physical exam normal, without neurological abnormalities. Auxological parameters were within normal limits. Daily fluid balance monitoring confirmed polyuria polydipsia. Biochemistry laboratory analysis urine culture normal. Serum osmolality 297 mOsm/Kg H2O (285-305), whereas 80 (100-1100), suggesting diabetes insipidus. Anterior pituitary function preserved. Since parents refused give consent water deprivation test, treatment Desmopressin administered ex juvantibus diagnosis AVP deficiency (or central insipidus). Brain MRI revealed stalk thickening (4 mm) contrast enhancement, posterior bright spot on T1 weighted imaging. Those signs consistent neuroinfundibulohypophysitis. Immunoglobulin levels Low doses oral sufficient control patient's symptoms, normalizing serum urinary values daily at discharge. 2 months showed stable thicken still undetectable pituitary. Due persistence polydipsia, therapy adjusted by increasing dosage number administrations. Clinical neuroradiological follow-up ongoing.Hypophysitis a rare disorder characterized lymphocytic, granulomatous, plasmacytic, or xanthomatous infiltration gland stalk. Common manifestations are headache, hypopituitarism, To date, only time correlation between SARS-CoV-2 infection hypophysitis subsequent hypopituitarism been reported. Further studies will needed deepen possible causal link deficiency.

Язык: Английский

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Hormonal Implications of SARS‐CoV‐2: A Review of Endocrine Disruptions

Scientifica, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

To improve medical care and rehabilitation algorithms for patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is important to evaluate summarize the available data on effect of infection (COVID-19) endocrine system. The purpose this review was study COVID-19 scientific novelty evaluation system potential hormones susceptibility COVID-19. results show that vulnerable disorders caused COVID-19, mainly thyroid dysfunction hyperglycemia. information in published literature mentioned here contains some unclear aspects contradictory data, but much remains be studied clarified regarding impact In particular, concerns hyperglycemic status who have had infection, which extremely future metabolic health survivors. This contributes discourse systematically synthesizing disparate studies identify patterns, gaps, emerging trends concerning effects By integrating these findings, offers a novel perspective hormonal interactions influencing outcomes, proposing new hypotheses frameworks research.

Язык: Английский

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Case Report: Hypothalamic Amenorrhea Following COVID-19 Infection and Review of Literatures

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Июнь 10, 2022

SARS-CoV-2 infection, responsible for the coronavirus disease 2019 (COVID-19), can impair any organ system including endocrine glands. However, hypothalamic–pituitary dysfunctions following infection remain largely unexplored. We described a case of hypothalamic amenorrhea in 36-year-old healthy woman. The diagnostic workup excluded all causes secondary amenorrhea, agreement to current guidelines, whereas gonadotropin increase response GnRH analogue tests was suggestive impairment. Therefore, since our patient did not present organic cause disorder, we hypothesized that her deficiency may have been consequence infection. This assumption, besides on temporal consecutio, is strengthened by fact circuits, altering axes, given angiotensin-converting enzyme 2 receptors also observed hypothalamus. reviewed literature regarding dysfunction patients with No study has previously female hypogonadotropic hypogonadism COVID-19. suggest clinicians focusing greater attention this possible disorder.

Язык: Английский

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Sequelae of long COVID, known and unknown: A review of updated information

BioScience Trends, Год журнала: 2023, Номер 17(2), С. 85 - 116

Опубликована: Март 13, 2023

Over three years have passed since the COVID-19 pandemic started. The dangerousness and impact of should definitely not be ignored or underestimated. Other than symptoms acute infection, long-term associated with SARS-CoV-2 which are referred to here as "sequelae long COVID (LC)", also a conspicuous global public health concern. Although such sequelae were well-documented, understanding insights regarding LC-related remain inadequate due limitations previous studies (the follow-up, methodological flaws, heterogeneity among studies, etc.). Notably, robust evidence diagnosis treatment certain LC insufficient has been stumbling block better management these patients. This awkward situation motivated us conduct this review. Here, we comprehensively reviewed updated information, particularly focusing on clinical issues. We attempt provide latest information by systematically reviewing involvement main organ systems. propose paths for future exploration based available knowledge authors' experience. believe that take-home messages will helpful gain into ultimately benefit practice in treating sequelae.

Язык: Английский

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Hypopituitarism and COVID-19

Pituitary, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Язык: Английский

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Revisiting the endocrine and metabolic manifestations of COVID-19 two years into the pandemic

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2022, Номер 23(2), С. 133 - 136

Опубликована: Фев. 19, 2022

Язык: Английский

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Pituitary apoplexy in the aftermath of a SARS-CoV-2 infection: a case series from Amiens University Hospital

European Journal of Endocrinology, Год журнала: 2022, Номер 187(3), С. K19 - K25

Опубликована: Июнь 27, 2022

Since the outbreak of COVID-19 pandemic, several cases pituitary apoplexy (PA) following a SARS-CoV-2 infection have been described in countries. Here, we describe case series PA occurring aftermath to alert physicians about possible neuro-endocrinological damage caused by virus that can lead visual sequelae and hypopituitarism.We retrospectively identified all adult patients treated at Amiens University Hospital between March 2020 May 2021 for confirmed cerebral imaging an RT-PCR-confirmed infection.Eight (six women, two men) occurred were reviewed this study. The mean age diagnosis was 67.5 ± 9.8 years. Only one patient had 'known' non-functional macroadenoma. most common symptom sudden headache. Brain typical cases. required decompression surgery, whereas others managed conservatively. clinical outcome favorable but without recovery their deficiencies. There no diabetes insipidus.This series, largest literature, reinforces strength, consistency, coherence association PA. Our study provides support hypothesis may be new precipitating factor It is essential practitioners alerted disease due so such are recognized appropriately managed, hence improving prognosis.

Язык: Английский

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Hypophysitis in COVID-19: a systematic review

Pituitary, Год журнала: 2024, Номер 27(6), С. 874 - 888

Опубликована: Окт. 15, 2024

Язык: Английский

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Neuroimmunoendocrinology of SARS-CoV-2 Infection

Biomedicines, Год журнала: 2022, Номер 10(11), С. 2855 - 2855

Опубликована: Ноя. 8, 2022

This review is aimed at illustrating and discussing the neuroimmune endocrinological aspects of SARS-CoV-2 infection in light studies on this topic that have so far appeared literature. The most characteristic findings pending controversies were derived by PubMed Scopus databases. We included original observational studies, reviews, meta-analysis, case reports. entry coronavirus into susceptible cells allowed interaction with an ecto-enzyme located human cells, angiotensin-converting enzyme 2 (ACE2). also targets central nervous system (CNS), including hypothalamic-pituitary structures, as their tissues express ACE2, ACE2 mRNA expression hypothalamus pituitary gland has been confirmed autoptic study patients who died COVID 19. may cause endocrine disorders acute phase post-COVID period, particularly due to effects virus CNS level involving axis. aggression hypothalamus-pituitary region elicit autoimmune process axis, responsible consequently for functional satellite glands. Adrenal, thyroid gonadal dysfunctions, well alterations GH prolactin secretions, reported. However, extent which COVID-19 contributes short- long-term currently being discussed deserves further detailed research.

Язык: Английский

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The interplay between severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and the hypothalamic and endocrinal disorders: A Mini-review

Egyptian journal of Immunology, Год журнала: 2023, Номер 30(1), С. 73 - 86

Опубликована: Янв. 1, 2023

The worldwide medical systems are still being severely impacted by the coronavirus disease-2019 (COVID-19) pandemic, which is responsible for catastrophic mortality and morbidity. It becomes more obvious that this unique respiratory virus's impacts go beyond system as time goes on our comprehension of it deepens. transmembrane serine protease 2 (TMPRSS2) protein necessary severe acute syndrome 2, cause COVID-19, to gain cellular entry through angiotensin-converting enzyme (ACE2) receptor. Most endocrine glands exhibit high levels expression ACE2 TMPRSS2. This pays attention effect COVID-19 system. Besides its capability pass central nervous especially hypothalamus inducing a lot functional disorders in individuals. Although effective vaccines became widely available, declined but shifting lengthy health survivors. To inform suitable research management, review provides an overview data examining besides hypothalamus. In addition, we reported if endocrinal thalamic could affect incidence progress COVID-19.

Язык: Английский

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