Thiamine pretreatment improves endotoxemia-related liver injury and cholestatic complications by regulating galactose metabolism and inhibiting macrophage activation

International Immunopharmacology, Год журнала: 2022, Номер 108, С. 108892 - 108892

Опубликована: Май 28, 2022

Язык: Английский

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Fecal and Urinary Adipokines as Disease Biomarkers

Biomedicines, Год журнала: 2023, Номер 11(4), С. 1186 - 1186

Опубликована: Апрель 16, 2023

The use of biomarkers is great clinical value for the diagnosis and prognosis disease assessment treatment efficacy. In this context, adipokines secreted from adipose tissue are interest, as their elevated circulating levels associated with a range metabolic dysfunctions, inflammation, renal hepatic diseases cancers. addition to serum, can also be detected in urine feces, current experimental evidence on analysis fecal urinary adipokine points potential biomarkers. This includes increased adiponectin, lipocalin-2, leptin interleukin-6 (IL-6) an association chemerin well lipocalin-2 active inflammatory bowel diseases. Urinary IL-6 upregulated rheumatoid arthritis may become early marker kidney transplant rejection, while decompensated liver cirrhosis acute gastroenteritis. addition, galectin-3 stool emerge biomarker several With feces patients being cost-efficient non-invasive, identification utilization could advantage predicting outcomes. review article highlights data abundance selected underscoring serve diagnostic prognostic

Язык: Английский

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Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose − induced trophoblast cells apoptosis via galectin-3/foxc1 pathway

Molecular Medicine, Год журнала: 2023, Номер 29(1)

Опубликована: Авг. 25, 2023

Abstract Objective This study was to evaluate plasma galectin-3 levels from early pregnancy delivery and explore the effects of on function trophoblast cells under high glucose exposure. Methods The were quantified by enzyme-linked immunosorbent assay (ELISA) in China National Birth Cohort (CNBC) at Peking University First Hospital, underlying signaling pathway identified protein–protein interaction (PPI) analysis, gene set enrichment analysis (GSEA), quantitative PCR (qPCR), western blotting, small interfering RNA (siRNA) transfections, flow cytometry. Results Significantly higher found patients with gestational diabetes mellitus (GDM group; n = 77) during first second trimesters than that healthy pregnant women (HP 113) ( P < 0.05). No significant differences detected between GDM HP groups maternal third-trimester blood cord blood. PPI suggested potential interactions foxc1. findings GSEA showed involved cytochrome P450-related complement-related pathways, foxc1 associated type I mellitus. Additionally, (25 mM) significantly increased expression induced apoptosis HTR-8/SVneo cells. Further vitro experiments galectin-3/foxc1 could protect against − apoptosis. Conclusion Future studies required validate whether might become a biomarker for hyperglycemia pregnancy. Elevated be vital protective mechanism among those exposed Graphical

Язык: Английский

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Galectin-3 and Severity of Liver Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease

Protein and Peptide Letters, Год журнала: 2024, Номер 31(4), С. 290 - 304

Опубликована: Апрель 1, 2024

Abstract: Metabolic dysfunction-associated Fatty Liver Disease (MAFLD) is a chronic liver disease characterized by the accumulation of fat in and hepatic steatosis, which can progress to critical conditions, including Steatohepatitis (MASH), fibrosis, cirrhosis, hepatocellular carcinoma. Galectin-3, member galectin family proteins, has been involved cascades that are responsible for pathogenesis progression fibrosis MAFLD. This review summarizes present understanding role galectin-3 severity MAFLD its associated fibrosis. The article assesses underlying galectin-3-mediated fibrogenesis, triggering stellate cells, regulation extracellular degradation, modulation immune reactions responses. It also highlights assessments potential diagnostic therapeutic implications during Overall, this provides insights into multifaceted interaction between MAFLD, could lead development novel strategies diagnosis treatment prevalent disease.

Язык: Английский

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Identification and functional characterization of galectin-3 in silver pomfret (Pampus argenteus)

Aquaculture, Год журнала: 2024, Номер 592, С. 741241 - 741241

Опубликована: Июнь 15, 2024

Язык: Английский

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