Endokrynologia Polska,
Journal Year:
2023,
Volume and Issue:
74(5), P. 536 - 543
Published: Oct. 30, 2023
Introduction:
Galectin-3
(Gal-3)
and
fetuin-A
(Fet-A)
are
cytokines
that
participate
in
inflammation
insulin
resistance.
Previous
studies
have
found
altered
Gal-3
Fet-A
levels
circulation
correlate
with
diabetic
complications.
However,
whether
they
all
associated
retinopathy
(DR)
has
been
little
investigated.
The
aim
of
this
study
was
to
assess
plasma
concentrations,
investigate
their
associations
the
presence
DR
type
2
diabetes
mellitus
(T2DM)
patients.
Material
methods:
A
total
100
T2DM
patients
were
enrolled,
among
which
there
50
without
(non
retinopathy,
NDR
group)
(DR
group).
Clinical
parameters
collected,
measured
by
enzyme-linked
immunosorbent
assay
(ELISA).
Results:
Both
be
increased
respect
controls,
correlated
positively
Fet-A.
Bivariate
correlation
analysis
revealed
haemoglobin
A1c
(HbA
1c
),
while
negatively
fasting
C
peptide
(FC-P)
homocysteine
(Hcy).
Binary
logistic
regression
suggested
elevated
related
risk
DR.
ROC
curve
displayed
combination
exhibited
better
diagnostic
value
for
Conclusions:
patients,
occurrence
indicators
showed
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(10), P. 3519 - 3519
Published: May 17, 2023
A
novel
cardiovascular
stress
biomarker
known
as
galectin-3
might
be
useful
for
anticipating
adverse
outcomes.
The
objective
of
the
current
investigation
was
to
assess
association
between
serum
levels
and
aortic
stiffness
(AS)
in
196
patients
on
peritoneal
dialysis.
An
enzyme-linked
immunosorbent
examination
a
cuff-based
volumetric
displacement
were
employed
determine
carotid-femoral
pulse
wave
velocity
(cfPWV),
respectively.
AS
group
had
48
total
(24.5%)
with
cfPWV
greater
than
10
m/s.
group,
when
compared
without
AS,
significantly
higher
prevalence
diabetes
mellitus
hypertension
addition
fasting
glucose
levels,
waist
circumference,
systolic
blood
pressure,
levels.
Multivariate
logistic
linear
regression
analysis
demonstrated
that
glactin-3
gender
age,
independently
associated
AS.
Serum
linked
according
receiver
operating
characteristic
curve
analysis,
an
area
under
0.648
(95%
confidence
interval,
0.576-0.714;
p
=
0.0018).
In
summary,
there
significant
correlation
undergoing
dialysis
therapy
end-stage
kidney
disease.
Medicines,
Journal Year:
2023,
Volume and Issue:
10(2), P. 15 - 15
Published: Jan. 19, 2023
In
this
article,
we
discuss
the
main
aspects
regarding
recognition
of
cell
surface
glycoconjugates
and
immunomodulation
responses
against
progression
certain
pathologies,
such
as
cancer
infectious
diseases.
first
part,
talk
about
different
delve
deeper
into
importance
N-glycans
in
immunotherapy.
Then,
describe
two
important
lectin
families
that
have
been
very
well
studied
last
20
years.
Examples
include
sialic
acid-binding
immunoglobulin
(Ig)-like
lectins
(siglecs),
galectins.
Finally,
a
topic
needs
to
be
better
addressed
field
glycoimmunology:
impact
oncofetal
antigens
on
cells
immune
system.
New
findings
area
are
great
for
advancement,
especially
oncology,
since
it
is
already
known
cellular
interactions
mediated
by
carbohydrate–carbohydrate
and/or
carbohydrate
proteins
able
modulate
types
events
compromise
functionality
responses.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(11), P. 9721 - 9721
Published: June 3, 2023
Diabetic
retinopathy
(DR)
is
the
most
frequent
microvascular
retinal
complication
of
diabetic
patients,
contributing
to
loss
vision.
Recently,
neuroinflammation
and
neurodegeneration
have
emerged
as
key
players
in
DR
progression,
therefore,
this
review
examines
neuroinflammatory
molecular
basis
DR.
We
focus
on
four
important
aspects
neuroinflammation:
(i)
exacerbation
endoplasmic
reticulum
(ER)
stress;
(ii)
activation
NLRP3
inflammasome;
(iii)
role
galectins;
(iv)
purinergic
2X7
receptor
(P2X7R).
Moreover,
proposes
selective
inhibition
galectins
P2X7R
a
potential
pharmacological
approach
prevent
progression
Endokrynologia Polska,
Journal Year:
2023,
Volume and Issue:
74(5), P. 536 - 543
Published: Oct. 30, 2023
Introduction:
Galectin-3
(Gal-3)
and
fetuin-A
(Fet-A)
are
cytokines
that
participate
in
inflammation
insulin
resistance.
Previous
studies
have
found
altered
Gal-3
Fet-A
levels
circulation
correlate
with
diabetic
complications.
However,
whether
they
all
associated
retinopathy
(DR)
has
been
little
investigated.
The
aim
of
this
study
was
to
assess
plasma
concentrations,
investigate
their
associations
the
presence
DR
type
2
diabetes
mellitus
(T2DM)
patients.
Material
methods:
A
total
100
T2DM
patients
were
enrolled,
among
which
there
50
without
(non
retinopathy,
NDR
group)
(DR
group).
Clinical
parameters
collected,
measured
by
enzyme-linked
immunosorbent
assay
(ELISA).
Results:
Both
be
increased
respect
controls,
correlated
positively
Fet-A.
Bivariate
correlation
analysis
revealed
haemoglobin
A1c
(HbA
1c
),
while
negatively
fasting
C
peptide
(FC-P)
homocysteine
(Hcy).
Binary
logistic
regression
suggested
elevated
related
risk
DR.
ROC
curve
displayed
combination
exhibited
better
diagnostic
value
for
Conclusions:
patients,
occurrence
indicators
showed
