The causal association between cardiovascular proteins and diabetic nephropathy: a Mendelian randomization study
International Urology and Nephrology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
Язык: Английский
No Genetic Causality between Branched-Chain Amino Acids and Diabetic Nephropathy: A Two-Sample Mendelian Randomization Study
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 25, 2024
Abstract
Background
Numerous
studies
have
reported
the
close
relationship
between
branched-chain
amino
acids
(BCAA)
and
diabetic
nephropathy
(DN).
Nevertheless,
whether
there
is
a
genetically
causal
association
them
remains
profoundly
elusive.
Methods
A
two-sample
Mendelian
randomization
(MR)
analysis
was
performed
using
large
genome-wide
of
European
population.
The
primarily
evaluated
by
inverse
variance
weighted
(IVW)
method.
In
addition,
MR-Egger
regression,
median,
simple
mode,
MR-weighted
mode
were
also
conducted
as
supplemented
methods.
For
sensitivity,
Cochrane’s
Q
test,
MR-PRESSO
employed
to
evaluate
heterogeneity
pleiotropy,
respectively.
Results
According
IVW
method,
no
significant
effect
measured
three
BCAA
DN
(valine:
OR:
1.202,
95%
CI:
0.714–2.023,
P
=
0.488;
isoleucine:
0.878,
0.400–1.924,
0.744;
leucine:
1.395,
0.686–2.839,
0.358;
total
BCAA:
1.374,
0.703–2.685,
0.352).
reverse
MR
analysis,
an
exposure
factor
had
on
1.004,
0.994–1.014,
0.412;
0.999,
0.990–1.009,
0.910;
1.001,
0.992–1.011,
0.802;
1.002,
0.993–1.012,
0.628).
Conclusion
Our
results
first
demonstrated
at
genetic
level.
Язык: Английский
Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 9, 2024
Nephrotic
syndrome
(NS)
represents
a
prevalent
among
various
chronic
kidney
disease
pathologies
and
is
known
for
its
higher
severity
worse
prognosis
compared
with
glomerulonephritis.
Understanding
pathogenesis
identifying
more
effective
treatment
modalities
have
long
been
concern
of
specialists.
With
the
introduction
gut-kidney
axis
concept
progress
in
omics
technologies,
alterations
gut
microbiota
observed
primary
secondary
NS.
This
link
has
extensively
researched
conditions
such
as
diabetic
nephropathy
immunoglobulin
A
(IgA)
nephropathy.
Thus,
dysbiosis
seen
crucial
contributing
factor
NS;
however,
there
lack
comprehensive
reviews
that
elucidate
changes
across
different
NS
describe
mechanistic
role
disease.
Moreover,
serving
an
innate
regulator
microbiota,
traditional
Chinese
medicine
(TCM)
potential
to
exert
profound
impact
on
expression
inflammation-promoting
agents,
decreasing
levels
endotoxins
uremic
toxins.
In
addition,
it
strengthens
stability
intestinal
barrier
while
controlling
metabolic
function
body
through
efficient
modulation
microbiota.
intricate
process
yields
far-reaching
consequences
Язык: Английский